PMID- 25834096
OWN - NLM
STAT- MEDLINE
DCOM- 20150825
LR  - 20181202
IS  - 1732-2693 (Electronic)
IS  - 0032-5449 (Linking)
VI  - 68
DP  - 2014 Dec 29
TI  - [The hematological malignancies related to primary hypereosinophilia and their 
      diagnostics].
PG  - 1530-7
LID - 10.5604/17322693.1134167 [doi]
AB  - Published in 2008, by experts of the World Health Organization, the new 
      classification of hematological malignancies forced a change of look at 
      chromosomal aberrations and gene mutations, which are important in establishing 
      the diagnosis and prognosis for patients with these malignancies. The new 
      classification includes a new category of neoplasms - hematological malignancies 
      with hypereosinophilia. Due to the high diversity of causes of hypereosinophilia 
      and underlying genetic changes, their differential diagnosis is based on 
      classical cytogenetics, fluorescence in situ hybridization (FISH) and genetic 
      molecular techniques. Cytogenetic analysis of bone marrow cells showed that the 
      majority of hypereosinophilia cases can be characterized by the presence of 
      normal karyotype. Therefore, routine cytogenetic diagnostics should be 
      complemented by FISH with break-apart probes for potentially rearranged genes 
      (e.g., CBFB, ETV6) and unique probes for fusion genes (e.g., FIP1L1-PDGFRA), 
      specific for hypereosinophilia-associated diseases. In differential diagnosis of 
      hypereosinophilia, the analysis of characteristic gene mutations (e.g., cKIT) and 
      gene fusions (e.g., ETV6-PDGFRB) is also applied, using molecular genetic 
      methods.
FAU - Skonieczka, Katarzyna
AU  - Skonieczka K
AD  - Katedra i Zaklad Genetyki Klinicznej Collegium Medicum im. L. Rydygiera w 
      Bydgoszczy, UMK w Toruniu.
FAU - Matiakowska, Karolina
AU  - Matiakowska K
AD  - Katedra i Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku UM we 
      Wroclawiu.
FAU - Haus, Olga
AU  - Haus O
AD  - Katedra i Zaklad Genetyki Klinicznej Collegium Medicum im. L. Rydygiera w 
      Bydgoszczy, UMK w Toruniu; Katedra i Klinika Hematologii, Nowotworow Krwi i 
      Transplantacji Szpiku UM we Wroclawiu.
LA  - pol
PT  - Journal Article
PT  - Review
TT  - Nowotwory ukladu krwiotworczego przebiegajace z pierwotna hipereozynofilia i ich 
      diagnostyka.
DEP - 20141229
PL  - Poland
TA  - Postepy Hig Med Dosw (Online)
JT  - Postepy higieny i medycyny doswiadczalnej (Online)
JID - 101206517
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - *Chromosome Aberrations
MH  - *Chromosome Deletion
MH  - Cytogenetics
MH  - Eosinophilia/*diagnosis/*genetics
MH  - *Gene Rearrangement
MH  - Hematologic Neoplasms/*diagnosis/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Oncogene Proteins, Fusion/genetics
EDAT- 2014/01/01 00:00
MHDA- 2015/08/26 06:00
CRDT- 2015/04/03 06:00
PHST- 2015/04/03 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2015/08/26 06:00 [medline]
AID - 1134167 [pii]
AID - 10.5604/17322693.1134167 [doi]
PST - epublish
SO  - Postepy Hig Med Dosw (Online). 2014 Dec 29;68:1530-7. doi: 
      10.5604/17322693.1134167.