PMID- 25834642
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150402
LR  - 20220408
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 7
DP  - 2015
TI  - The impact of sleep disorders on glucose metabolism: endocrine and molecular 
      mechanisms.
PG  - 25
LID - 10.1186/s13098-015-0018-3 [doi]
LID - 25
AB  - Modern lifestyle has profoundly modified human sleep habits. Sleep duration has 
      shortened over recent decades from 8 to 6.5 hours resulting in chronic sleep 
      deprivation. Additionally, irregular sleep, shift work and travelling across time 
      zones lead to disruption of circadian rhythms and asynchrony between the master 
      hypothalamic clock and pacemakers in peripheral tissues. Furthermore, obstructive 
      sleep apnea syndrome (OSA), which affects 4 - 15% of the population, is not only 
      characterized by impaired sleep architecture but also by repetitive hemoglobin 
      desaturations during sleep. Epidemiological studies have identified impaired 
      sleep as an independent risk factor for all cause of-, as well as for 
      cardiovascular, mortality/morbidity. More recently, sleep abnormalities were 
      causally linked to impairments in glucose homeostasis, metabolic syndrome and 
      Type 2 Diabetes Mellitus (T2DM). This review summarized current knowledge on the 
      metabolic alterations associated with the most prevalent sleep disturbances, i.e. 
      short sleep duration, shift work and OSA. We have focused on various endocrine 
      and molecular mechanisms underlying the associations between inadequate sleep 
      quality, quantity and timing with impaired glucose tolerance, insulin resistance 
      and pancreatic beta-cell dysfunction. Of these mechanisms, the role of the 
      hypothalamic-pituitary-adrenal axis, circadian pacemakers in peripheral tissues, 
      adipose tissue metabolism, sympathetic nervous system activation, oxidative 
      stress and whole-body inflammation are discussed. Additionally, the impact of 
      intermittent hypoxia and sleep fragmentation (key components of OSA) on 
      intracellular signaling and metabolism in muscle, liver, fat and pancreas are 
      also examined. In summary, this review provides endocrine and molecular 
      explanations for the associations between common sleep disturbances and the 
      pathogenesis of T2DM.
FAU - Briancon-Marjollet, Anne
AU  - Briancon-Marjollet A
AD  - Universite Grenoble Alpes, HP2, F-38041 Grenoble, Cedex France.
AD  - INSERM U1042, F-38041 Grenoble, Cedex France.
FAU - Weiszenstein, Martin
AU  - Weiszenstein M
AD  - Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of 
      Medicine, Charles University, Prague, Czech Republic.
FAU - Henri, Marion
AU  - Henri M
AD  - Universite Grenoble Alpes, HP2, F-38041 Grenoble, Cedex France.
AD  - INSERM U1042, F-38041 Grenoble, Cedex France.
FAU - Thomas, Amandine
AU  - Thomas A
AD  - Universite Grenoble Alpes, HP2, F-38041 Grenoble, Cedex France.
AD  - INSERM U1042, F-38041 Grenoble, Cedex France.
FAU - Godin-Ribuot, Diane
AU  - Godin-Ribuot D
AD  - Universite Grenoble Alpes, HP2, F-38041 Grenoble, Cedex France.
AD  - INSERM U1042, F-38041 Grenoble, Cedex France.
FAU - Polak, Jan
AU  - Polak J
AD  - Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of 
      Medicine, Charles University, Prague, Czech Republic.
AD  - 2nd Internal Medicine Department, University Hospital Kralovske Vinohrady, 
      Prague, Czech Republic.
AD  - Sports Medicine Department, Third Faculty of Medicine, Charles University in 
      Prague, Ruska 87, Praha 10, 100 00 Czech Republic.
LA  - eng
PT  - Journal Article
DEP - 20150324
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC4381534
OTO - NOTNLM
OT  - Diabetes
OT  - Insulin resistance
OT  - Intermittent hypoxia
OT  - Metabolic syndrome
OT  - Obesity
OT  - Obstructive sleep apnea
OT  - Shift working
OT  - Sleep
EDAT- 2015/04/04 06:00
MHDA- 2015/04/04 06:01
PMCR- 2015/03/24
CRDT- 2015/04/03 06:00
PHST- 2014/08/03 00:00 [received]
PHST- 2015/03/05 00:00 [accepted]
PHST- 2015/04/03 06:00 [entrez]
PHST- 2015/04/04 06:00 [pubmed]
PHST- 2015/04/04 06:01 [medline]
PHST- 2015/03/24 00:00 [pmc-release]
AID - 18 [pii]
AID - 10.1186/s13098-015-0018-3 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2015 Mar 24;7:25. doi: 10.1186/s13098-015-0018-3. 
      eCollection 2015.