PMID- 25834745
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150402
LR  - 20220331
IS  - 2090-2247 (Print)
IS  - 2090-2255 (Electronic)
VI  - 2015
DP  - 2015
TI  - Similar and additive effects of ovariectomy and diabetes on insulin resistance 
      and lipid metabolism.
PG  - 567945
LID - 10.1155/2015/567945 [doi]
LID - 567945
AB  - Type 2 diabetes mellitus (T2DM) is among the leading causes of death in 
      postmenopausal women. The disruption of ovarian function may contribute to the 
      incidence of T2DM. The purpose of this study was to investigate the effects of 
      ovariectomy and T2DM on glucose and lipid homeostasis, perilipin levels in 
      adipose tissues, as a lipolytic regulator, and levels of certain adipokines. 
      Ovariectomized (OVX) rats were used as a model for postmenopausal women. The 
      study was performed on sham, OVX, sham diabetic, and OVX diabetic female rats. 
      The results indicated that ovariectomy alters adipose tissue metabolism through 
      reducing perilipin content in white adipose tissue (WAT); however it has no 
      effect on perilipin level in brown adipose tissue (BAT). OVX diabetic females 
      suffer from serious metabolic disturbances, suggested by exacerbation of insulin 
      resistance in terms of disrupted lipid profile, higher HOMA-IR, hyperinsulinemia, 
      higher leptin, and lower adiponectin concentrations. These metabolic derangements 
      may underlie the predisposition for cardiovascular disease in women after 
      menopause. Therefore, for efficient treatment, the menopausal status of diabetic 
      female should be addressed, and the order of events is of great importance 
      because ovariectomy following development of diabetes has more serious 
      complications compared to development of diabetes as result of menopause.
FAU - Tawfik, Shady H
AU  - Tawfik SH
AD  - Department of Biochemistry, Medical Research Institute, Alexandria University, 
      Egypt.
FAU - Mahmoud, Bothaina F
AU  - Mahmoud BF
AD  - Department of Biochemistry, Medical Research Institute, Alexandria University, 
      Egypt.
FAU - Saad, Mohamed I
AU  - Saad MI
AD  - Department of Biochemistry, Medical Research Institute, Alexandria University, 
      Egypt.
FAU - Shehata, Mona
AU  - Shehata M
AD  - Department of Physiology, Medical Research Institute, Alexandria University, 
      Egypt.
FAU - Kamel, Maher A
AU  - Kamel MA
AD  - Department of Biochemistry, Medical Research Institute, Alexandria University, 
      Egypt.
FAU - Helmy, Madiha H
AU  - Helmy MH
AD  - Department of Biochemistry, Medical Research Institute, Alexandria University, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20150305
PL  - United States
TA  - Biochem Res Int
JT  - Biochemistry research international
JID - 101546751
PMC - PMC4365318
EDAT- 2015/04/04 06:00
MHDA- 2015/04/04 06:01
PMCR- 2015/03/05
CRDT- 2015/04/03 06:00
PHST- 2015/01/24 00:00 [received]
PHST- 2015/02/24 00:00 [accepted]
PHST- 2015/04/03 06:00 [entrez]
PHST- 2015/04/04 06:00 [pubmed]
PHST- 2015/04/04 06:01 [medline]
PHST- 2015/03/05 00:00 [pmc-release]
AID - 10.1155/2015/567945 [doi]
PST - ppublish
SO  - Biochem Res Int. 2015;2015:567945. doi: 10.1155/2015/567945. Epub 2015 Mar 5.