PMID- 25835233
OWN - NLM
STAT- MEDLINE
DCOM- 20150604
LR  - 20180813
IS  - 0300-9831 (Print)
IS  - 0300-9831 (Linking)
VI  - 84
IP  - 1-2
DP  - 2014
TI  - Vitamin D supplementation and serum levels of magnesium and selenium in type 2 
      diabetes mellitus patients: gender dimorphic changes.
PG  - 27-34
LID - 10.1024/0300-9831/a000190 [doi]
AB  - The aim of our study was to evaluate the effects of vitamin D supplementation on 
      circulating levels of magnesium and selenium in patients with type 2 diabetes 
      mellitus (T2DM). A total of 126 adult Saudi patients (55 men and 71 women, mean 
      age 53.6+/-10.7 years) with controlled T2DM were randomly recruited for the study. 
      All subjects were given vitamin D3 tablets (2000 IU/day) for six months. 
      Follow-up mean concentrations of serum 25-hydroxyvitamin D [25-(OH) vitamin D] 
      significantly increased in both men (34.1+/-12.4 to 57.8+/-17.0 nmol/L) and women 
      (35.7+/-13.5 to 60.1+/-18.5 nmol/L, p<0.001), while levels of parathyroid hormone 
      (PTH) decreased significantly in both men (1.6+/-0.17 to 0.96+/-0.10 pmol/L, p=0.003) 
      and women (1.6+/-0.17 to 1.0+/-0.14 pmol/L, p=0.02). In addition, there was a 
      significant increase in serum levels of selenium and magnesium in men and women 
      (p-values<0.001 and 0.04, respectively) after follow-up. In women, a significant 
      correlation was observed between delta change (variables at six months-variable 
      at baseline) of serum magnesium versus high-density lipoprotein (HDL)-cholesterol 
      (r=0.36, p=0.006) and fasting glucose (r=-0.33, p=0.01). In men, there was a 
      significant correlation between serum selenium and triglycerides (r=0.32, 
      p=0.04). Vitamin D supplementation improves serum concentrations of magnesium and 
      selenium in a gender-dependent manner, which in turn could affect several 
      cardiometabolic parameters such as glucose and lipids.
FAU - Al-Daghri, Nasser M
AU  - Al-Daghri NM
AD  - Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, 
      College of Science, King Saud University, Riyadh, Saudi Arabia, and Biomarkers 
      Research Program, Biochemistry Department, College of Science, King Saud 
      University, Riyadh, Saudi Arabia, and Center of Excellence in Biotechnology 
      Research, King Saud University, Riyadh, Saudi Arabia.
FAU - Alkharfy, Khalid M
AU  - Alkharfy KM
AD  - Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, 
      College of Science, King Saud University, Riyadh, Saudi Arabia, and Biomarkers 
      Research Program, Biochemistry Department, College of Science, King Saud 
      University, Riyadh, Saudi Arabia, and Clinical Pharmacy Department, College of 
      Pharmacy, King Saud University, Riyadh, Saudi Arabia.
FAU - Khan, Nasiruddin
AU  - Khan N
AD  - Biomarkers Research Program, Biochemistry Department, College of Science, King 
      Saud University, Riyadh, Saudi Arabia.
FAU - Alfawaz, Hanan A
AU  - Alfawaz HA
AD  - Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, 
      College of Science, King Saud University, Riyadh, Saudi Arabia, and College of 
      Food Science & Agriculture, Department of Food Science & Nutrition, King Saud 
      University, Riyadh, Saudi Arabia.
FAU - Al-Ajlan, Abdulrahman S
AU  - Al-Ajlan AS
AD  - Riyadh College of Health Sciences, King Saud University, Ministry of Higher 
      Education, Riyadh, Saudi Arabia.
FAU - Yakout, Sobhy M
AU  - Yakout SM
AD  - Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, 
      College of Science, King Saud University, Riyadh, Saudi Arabia.
FAU - Alokail, Majed S
AU  - Alokail MS
AD  - Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, 
      College of Science, King Saud University, Riyadh, Saudi Arabia, and Biomarkers 
      Research Program, Biochemistry Department, College of Science, King Saud 
      University, Riyadh, Saudi Arabia, and Center of Excellence in Biotechnology 
      Research, King Saud University, Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Int J Vitam Nutr Res
JT  - International journal for vitamin and nutrition research. Internationale 
      Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de 
      vitaminologie et de nutrition
JID - 1273304
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Triglycerides)
RN  - 1406-16-2 (Vitamin D)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - H6241UJ22B (Selenium)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Cholecalciferol/*administration & dosage
MH  - Cholesterol, HDL/blood
MH  - Diabetes Mellitus, Type 2/*blood/*drug therapy
MH  - Dietary Supplements
MH  - Fasting
MH  - Female
MH  - Humans
MH  - Magnesium/*blood
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Hormone
MH  - Saudi Arabia
MH  - Selenium/*blood
MH  - Sex Factors
MH  - Triglycerides/blood
MH  - Vitamin D/analogs & derivatives/blood
OTO - NOTNLM
OT  - Saudi Arabia
OT  - diabetes
OT  - hypovitaminosis D
OT  - magnesium
OT  - selenium
EDAT- 2014/01/01 00:00
MHDA- 2015/06/05 06:00
CRDT- 2015/04/04 06:00
PHST- 2015/04/04 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2015/06/05 06:00 [medline]
AID - DGL23562006U4H30 [pii]
AID - 10.1024/0300-9831/a000190 [doi]
PST - ppublish
SO  - Int J Vitam Nutr Res. 2014;84(1-2):27-34. doi: 10.1024/0300-9831/a000190.