PMID- 25838186
OWN - NLM
STAT- MEDLINE
DCOM- 20150731
LR  - 20220410
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 92
IP  - 2
DP  - 2015 Jun 1
TI  - High-quality t2-weighted 4-dimensional magnetic resonance imaging for radiation 
      therapy applications.
PG  - 430-7
LID - S0360-3016(15)00141-8 [pii]
LID - 10.1016/j.ijrobp.2015.01.035 [doi]
AB  - PURPOSE: The purpose of this study was to improve triggering efficiency of the 
      prospective respiratory amplitude-triggered 4-dimensional magnetic resonance 
      imaging (4DMRI) method and to develop a 4DMRI imaging protocol that could offer 
      T2 weighting for better tumor visualization, good spatial coverage and spatial 
      resolution, and respiratory motion sampling within a reasonable amount of time 
      for radiation therapy applications. METHODS AND MATERIALS: The respiratory state 
      splitting (RSS) and multi-shot acquisition (MSA) methods were analytically 
      compared and validated in a simulation study by using the respiratory signals 
      from 10 healthy human subjects. The RSS method was more effective in improving 
      triggering efficiency. It was implemented in prospective respiratory 
      amplitude-triggered 4DMRI. 4DMRI image datasets were acquired from 5 healthy 
      human subjects. Liver motion was estimated using the acquired 4DMRI image 
      datasets. RESULTS: The simulation study showed the RSS method was more effective 
      for improving triggering efficiency than the MSA method. The average reductions 
      in 4DMRI acquisition times were 36% and 10% for the RSS and MSA methods, 
      respectively. The human subject study showed that T2-weighted 4DMRI with 10 
      respiratory states, 60 slices at a spatial resolution of 1.5 x 1.5 x 3.0 mm(3) 
      could be acquired in 9 to 18 minutes, depending on the individual's breath 
      pattern. Based on the acquired 4DMRI image datasets, the ranges of peak-to-peak 
      liver displacements among 5 human subjects were 9.0 to 12.9 mm, 2.5 to 3.9 mm, 
      and 0.5 to 2.3 mm in superior-inferior, anterior-posterior, and left-right 
      directions, respectively. CONCLUSIONS: We demonstrated that with the RSS method, 
      it was feasible to acquire high-quality T2-weighted 4DMRI within a reasonable 
      amount of time for radiation therapy applications.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Du, Dongsu
AU  - Du D
AD  - Department of Radiation Oncology, Washington University School of Medicine, Saint 
      Louis, Missouri.
FAU - Caruthers, Shelton D
AU  - Caruthers SD
AD  - Philips Healthcare, Cleveland, Ohio.
FAU - Glide-Hurst, Carri
AU  - Glide-Hurst C
AD  - Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan.
FAU - Low, Daniel A
AU  - Low DA
AD  - Department of Radiation Oncology, University of California-Los Angeles, Los 
      Angeles, California.
FAU - Li, H Harold
AU  - Li HH
AD  - Department of Radiation Oncology, Washington University School of Medicine, Saint 
      Louis, Missouri.
FAU - Mutic, Sasa
AU  - Mutic S
AD  - Department of Radiation Oncology, Washington University School of Medicine, Saint 
      Louis, Missouri.
FAU - Hu, Yanle
AU  - Hu Y
AD  - Department of Radiation Oncology, Washington University School of Medicine, Saint 
      Louis, Missouri; Department of Radiation Oncology, Mayo Clinic in Arizona, 
      Phoenix, Arizona. Electronic address: Hu.Yanle@mayo.edu.
LA  - eng
GR  - R21 CA167092/CA/NCI NIH HHS/United States
GR  - 1R21CA167092/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Validation Study
DEP - 20150330
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Adult
MH  - *Algorithms
MH  - Efficiency
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - *Liver
MH  - Magnetic Resonance Imaging/*methods/standards
MH  - Male
MH  - *Movement
MH  - Radiotherapy/*methods/standards
MH  - *Respiration
MH  - Software
MH  - Time Factors
PMC - PMC4431950
MID - NIHMS676838
COIS- Conflict of interest: Dr. Caruthers is an employee of Phillips Healthcare.
EDAT- 2015/04/04 06:00
MHDA- 2015/08/01 06:00
PMCR- 2016/06/01
CRDT- 2015/04/04 06:00
PHST- 2014/09/06 00:00 [received]
PHST- 2015/01/12 00:00 [revised]
PHST- 2015/01/27 00:00 [accepted]
PHST- 2015/04/04 06:00 [entrez]
PHST- 2015/04/04 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - S0360-3016(15)00141-8 [pii]
AID - 10.1016/j.ijrobp.2015.01.035 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2015 Jun 1;92(2):430-7. doi: 
      10.1016/j.ijrobp.2015.01.035. Epub 2015 Mar 30.