PMID- 25838322
OWN - NLM
STAT- MEDLINE
DCOM- 20150915
LR  - 20180816
IS  - 0091-2174 (Print)
IS  - 0091-2174 (Linking)
VI  - 49
IP  - 1
DP  - 2015
TI  - BDNF promoter methylation associated with suicidal ideation in patients with 
      breast cancer.
PG  - 75-94
LID - 10.1177/0091217415574439 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) has been considered a risk 
      factor for suicidality. BDNF secretion is influenced by epigenetic (DNA 
      methylation) and genetic (val66met polymorphism) profiles. We aimed to 
      investigate the independent effects of BDNF promoter methylation status on 
      suicidal ideation as well as the effects of its interaction with the val66met 
      polymorphism in patients with breast cancer. METHODS: A total of279 patients with 
      breast cancer were evaluated 1 week after breast surgery, and 244 (87%) were 
      followed up 1 year later. Suicidal ideation was identified using the item 
      addressing suicidal thoughts on the Beck Depression Inventory. The independent 
      effects of BDNF methylation status on suicidal ideation at two points was 
      investigated using multivariable logistic regression models. The two-way 
      interactive effects of BDNF methylation status and the val66met polymorphism on 
      suicidal ideation were also estimated using the same models. RESULTS: Increased 
      BDNF methylation was significantly associated with suicidal ideation and 
      depression 1 year after breast surgery, and this association was independent of 
      potential covariates, including previous depression, current depressive symptoms, 
      and BDNF genotype. No significant methylation-genotype interactions were found. 
      CONCLUSIONS: The BDNF hypothesis and the epigenetic origin of suicidality in 
      patients with breast cancer were supported. BDNF gene methylation status may be a 
      biological marker for suicidality in patients with breast cancer.
CI  - (c) 2015 The Author(s).
FAU - Kim, Jae-Min
AU  - Kim JM
AD  - Chonnam National University Medical School, Gwangju, Korea.
FAU - Kang, Hee-Ju
AU  - Kang HJ
AD  - Chonnam National University Medical School, Gwangju, Korea.
FAU - Kim, Seon-Young
AU  - Kim SY
AD  - Chonnam National University Medical School, Gwangju, Korea.
FAU - Kim, Sung-Wan
AU  - Kim SW
AD  - Chonnam National University Medical School, Gwangju, Korea.
FAU - Shin, Il-Seon
AU  - Shin IS
AD  - Chonnam National University Medical School, Gwangju, Korea.
FAU - Kim, Hye-Ran
AU  - Kim HR
AD  - Chonnam National University Medical School, Gwangju, Korea.
FAU - Park, Min-Ho
AU  - Park MH
AD  - Chonnam National University Hwasun Hospital, Hwasun, Korea.
FAU - Shin, Myung-Geun
AU  - Shin MG
AD  - Chonnam National University Medical School, Gwangju, Korea.
FAU - Yoon, Jung-Han
AU  - Yoon JH
AD  - Chonnam National University Hwasun Hospital, Hwasun, Korea.
FAU - Yoon, Jin-Sang
AU  - Yoon JS
AD  - Chonnam National University Medical School, Gwangju, Korea jsyoon@chonnam.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Psychiatry Med
JT  - International journal of psychiatry in medicine
JID - 0365646
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Breast Neoplasms/*genetics/*psychology/surgery
MH  - DNA Methylation/genetics
MH  - Epigenesis, Genetic/genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Genotype
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Genetic/genetics
MH  - Promoter Regions, Genetic/*genetics
MH  - Republic of Korea
MH  - *Suicidal Ideation
OTO - NOTNLM
OT  - BDNF
OT  - DNA methylation
OT  - breast cancer
OT  - epigenetics
OT  - suicidality
EDAT- 2015/04/04 06:00
MHDA- 2015/09/16 06:00
CRDT- 2015/04/04 06:00
PHST- 2015/04/04 06:00 [entrez]
PHST- 2015/04/04 06:00 [pubmed]
PHST- 2015/09/16 06:00 [medline]
AID - 49/1/75 [pii]
AID - 10.1177/0091217415574439 [doi]
PST - ppublish
SO  - Int J Psychiatry Med. 2015;49(1):75-94. doi: 10.1177/0091217415574439.