PMID- 25839096
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20150505
IS  - 1525-6073 (Electronic)
IS  - 0742-0528 (Linking)
VI  - 32
IP  - 4
DP  - 2015 May
TI  - Diverse development and higher sensitivity of the circadian clocks to changes in 
      maternal-feeding regime in a rat model of cardio-metabolic disease.
PG  - 531-47
LID - 10.3109/07420528.2015.1014095 [doi]
AB  - Spontaneously hypertensive rats (SHR) develop cardiovascular and metabolic 
      pathology in adulthood when their circadian system exhibits significant 
      aberrances compared with healthy control rats. This study was aimed to elucidate 
      how the SHR circadian system develops during ontogenesis and to assess its 
      sensitivity to changes in maternal-feeding regime. Analysis of ontogenesis of 
      clock gene expression rhythms in the suprachiasmatic nuclei, liver and colon 
      revealed significant differences in SHR compared with Wistar rats. In the 
      suprachiasmatic nuclei of the hypothalamus (SCN) and liver, the development of a 
      high-amplitude expression rhythm selectively for Bmal1 was delayed compared with 
      Wistar rat. The atypical development of the SHR circadian clocks during postnatal 
      ontogenesis might arise from differences in maternal behavior between SHR and 
      Wistar rats that were detected soon after delivery. It may also arise from higher 
      sensitivity of the circadian clocks in the SHR SCN, liver and colon to maternal 
      behavior related to changes in the feeding regime because in contrast to Wistar 
      rat, the SHR SCN and peripheral clocks during the prenatal period and the hepatic 
      clock during the early postnatal period were phase shifted due to exposure of 
      mothers to a restricted feeding regime. The maternal restricted feeding regime 
      shifted the clocks despite the fact that the mothers were maintained under the 
      light/dark cycle. Our findings of the diverse development and higher sensitivity 
      of the developing circadian system of SHR to maternal cues might result from 
      previously demonstrated differences in the SHR circadian genotype and may 
      potentially contribute to cardiovascular and metabolic diseases, which the animal 
      model spontaneously develops.
FAU - Olejnikova, Lucie
AU  - Olejnikova L
AD  - Department of Neurohumoral Regulations, Institute of Physiology, v.v.i., Academy 
      of Science of the Czech Republic , Prague , Czech Republic.
FAU - Polidarova, Lenka
AU  - Polidarova L
FAU - Pauslyova, Lucia
AU  - Pauslyova L
FAU - Sladek, Martin
AU  - Sladek M
FAU - Sumova, Alena
AU  - Sumova A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150403
PL  - England
TA  - Chronobiol Int
JT  - Chronobiology international
JID - 8501362
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Circadian Clocks/*genetics
MH  - Circadian Rhythm/genetics/physiology
MH  - Feeding Behavior/*physiology
MH  - Female
MH  - Gene Expression/physiology
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Heart Diseases/*genetics/physiopathology
MH  - Liver/*metabolism
MH  - Male
MH  - Maternal Behavior/*physiology
MH  - Metabolic Diseases/*genetics/metabolism
MH  - Motor Activity/physiology
MH  - Photoperiod
MH  - Rats
MH  - Suprachiasmatic Nucleus/metabolism
OTO - NOTNLM
OT  - Circadian clock
OT  - clock gene
OT  - colon
OT  - liver
OT  - ontogenesis
OT  - spontaneously hypertensive rat
OT  - suprachiasmatic nucleus
EDAT- 2015/04/04 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/04/04 06:00
PHST- 2015/04/04 06:00 [entrez]
PHST- 2015/04/04 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - 10.3109/07420528.2015.1014095 [doi]
PST - ppublish
SO  - Chronobiol Int. 2015 May;32(4):531-47. doi: 10.3109/07420528.2015.1014095. Epub 
      2015 Apr 3.