PMID- 25840404
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1557-2501 (Electronic)
IS  - 1042-3931 (Linking)
VI  - 27
IP  - 4
DP  - 2015 Apr
TI  - The association between the extent of coronary artery disease and major bleeding 
      events after percutaneous coronary intervention: from the ACUITY trial.
PG  - 203-11
AB  - OBJECTIVE: We sought to evaluate the relation between the extent of coronary 
      artery disease (CAD) and bleeding risk in patients undergoing percutaneous 
      coronary intervention (PCI) for non-ST segment elevation acute coronary syndrome 
      (NSTEACS). BACKGROUND: Patients with severe CAD undergoing PCI for NSTEACS are at 
      high risk for recurrent adverse events. Hemorrhagic events after PCI are 
      associated with high rates of morbidity and mortality. Despite sharing many 
      common risk factors, the relationship between the extent of CAD and bleeding 
      after PCI remains understudied. METHODS: The SYNTAX score (SS) was used to 
      quantify the extent and severity of CAD. We stratified 2627 patients from the 
      ACUITY PCI cohort into SS groups based on score tertiles from the ACUITY trial 
      (<7, 7-12, and >12). Thirty-day major bleeding rates were determined for each 
      group. RESULTS: When stratified by ACUITY tertiles, 30-day major bleeding rates 
      were significantly greater in the highest SS tertile (>12) than in the 
      intermediate and lowest tertiles (P<.01). By multivariable analysis, the SS (by 
      augmentation of 1 point) remained independently associated with 30-day major 
      bleeding (hazard ratio = 1.03; 95% confidence interval, 1.01-1.04; P<.01). 
      CONCLUSION: The results of this large-scale study suggest that in addition to its 
      previously described association with adverse ischemic events, the extent of CAD, 
      as assessed by the SS, was independently associated with major bleeding after PCI 
      for NSTEACS.
FAU - Madhavan, Mahesh V
AU  - Madhavan MV
AD  - Columbia University Medical Center, The Cardiovascular Research Foundation, 111 
      East 59th Street, 12th Floor, New York, NY 10022 USA. pg2295@columbia.edu.
FAU - Genereux, Philippe
AU  - Genereux P
FAU - Palmerini, Tullio
AU  - Palmerini T
FAU - Caixeta, Adriano
AU  - Caixeta A
FAU - Xu, Ke
AU  - Xu K
FAU - McAndrew, Thomas C
AU  - McAndrew TC
FAU - Francese, Dominic P
AU  - Francese DP
FAU - Kirtane, Ajay J
AU  - Kirtane AJ
FAU - Mehran, Roxana
AU  - Mehran R
FAU - Stone, Gregg W
AU  - Stone GW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Invasive Cardiol
JT  - The Journal of invasive cardiology
JID - 8917477
SB  - IM
MH  - Acute Coronary Syndrome/*surgery
MH  - Aged
MH  - *Coronary Angiography
MH  - Coronary Artery Bypass
MH  - Coronary Artery Disease/*complications/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multicenter Studies as Topic
MH  - Multivariate Analysis
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Postoperative Hemorrhage/epidemiology/*etiology/mortality
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
EDAT- 2015/04/04 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/04/04 06:00
PHST- 2015/04/04 06:00 [entrez]
PHST- 2015/04/04 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PST - ppublish
SO  - J Invasive Cardiol. 2015 Apr;27(4):203-11.