PMID- 25841036
OWN - NLM
STAT- MEDLINE
DCOM- 20151209
LR  - 20191210
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 27
IP  - 4
DP  - 2015 Apr
TI  - The Transcriptional Regulator BBX19 Promotes Hypocotyl Growth by Facilitating 
      COP1-Mediated EARLY FLOWERING3 Degradation in Arabidopsis.
PG  - 1128-39
LID - 10.1105/tpc.15.00044 [doi]
AB  - Hypocotyl elongation is a highly coordinated physiological response regulated by 
      myriad internal and external cues. Here, we show that BBX19, a transcriptional 
      regulator with two B-box motifs, is a positive regulator of growth; diminished 
      BBX19 expression by RNA interference reduces hypocotyl length, and its 
      constitutive expression promotes growth. This function of BBX19 is dependent on 
      the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1), EARLY FLOWERING3 
      (ELF3), and PHYTOCHROME-INTERACTING FACTOR4 (PIF4) and PIF5. BBX19 is 
      nucleus-colocalized and interacts physically with COP1 and ELF3, a component of 
      the evening complex that represses the expression of PIF4 and PIF5. Moreover, 
      ELF3 protein abundance inversely correlates with BBX19 expression levels in a 
      COP1-dependent manner. By contrast, PIF expression, coinciding with the 
      initiation of hypocotyl growth in the early evening, is positively correlated 
      with the BBX19 transcript abundance. These results collectively establish BBX19 
      as an adaptor that binds to and recruits ELF3 for degradation by COP1 and, as 
      such, dynamically gates the formation of the evening complex, resulting in 
      derepression of PIF4/5. This finding refines our perspective on how plants grow 
      by providing a molecular link between COP1, ELF3, and PIF4/5 as an underlying 
      mechanism of photomorphogenic development in Arabidopsis thaliana.
CI  - (c) 2015 American Society of Plant Biologists. All rights reserved.
FAU - Wang, Chang-Quan
AU  - Wang CQ
AUID- ORCID: 0000-0003-3426-8761
AD  - Department of Plant Biology, University of California, Davis, California 95616.
FAU - Sarmast, Mostafa Khoshhal
AU  - Sarmast MK
AD  - Department of Plant Biology, University of California, Davis, California 95616.
FAU - Jiang, Jishan
AU  - Jiang J
AD  - Department of Plant Biology, University of California, Davis, California 95616.
FAU - Dehesh, Katayoon
AU  - Dehesh K
AUID- ORCID: 0000-0002-9312-8032
AD  - Department of Plant Biology, University of California, Davis, California 95616 
      kdehesh@ucdavis.edu.
LA  - eng
GR  - R01 GM107311/GM/NIGMS NIH HHS/United States
GR  - R01GM107311/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150403
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (BBX19 protein, Arabidopsis)
RN  - 0 (ELF3 protein, Arabidopsis)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Arabidopsis/*growth & development/*metabolism
MH  - Arabidopsis Proteins/genetics/*metabolism
MH  - Gene Expression Regulation, Plant
MH  - Hypocotyl/*growth & development/*metabolism
MH  - Transcription Factors/genetics/*metabolism
MH  - Ubiquitin-Protein Ligases
PMC - PMC4558699
EDAT- 2015/04/05 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/04/01
CRDT- 2015/04/05 06:00
PHST- 2015/01/17 00:00 [received]
PHST- 2015/03/13 00:00 [accepted]
PHST- 2015/04/05 06:00 [entrez]
PHST- 2015/04/05 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - tpc.15.00044 [pii]
AID - TPC201500044RAR1 [pii]
AID - 10.1105/tpc.15.00044 [doi]
PST - ppublish
SO  - Plant Cell. 2015 Apr;27(4):1128-39. doi: 10.1105/tpc.15.00044. Epub 2015 Apr 3.