PMID- 25841171
OWN - NLM
STAT- MEDLINE
DCOM- 20151204
LR  - 20220408
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 21
DP  - 2015 Apr 4
TI  - Serum nesfatin-1 is reduced in type 2 diabetes mellitus patients with peripheral 
      arterial disease.
PG  - 987-91
LID - 10.12659/MSM.892611 [doi]
AB  - BACKGROUND: Nesfatin-1, recently identified as a satiety regulator, elicits an 
      anti-atherosclerosis effect. Our study was designed to determine whether there is 
      an association between serum nesfatin-1 and the development and severity of 
      peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus 
      (T2DM). MATERIAL AND METHODS: This cross-sectional study included 355 T2DM 
      patients (200 without PAD and 155 with PAD). RESULTS: T2DM patients with PAD 
      exhibited marked lower serum nesfatin-1 concentrations than those without PAD. 
      Multivariable logistic regression analysis indicated an inverse association of 
      serum nesfatin-1 concentrations with the development of PAD in T2DM patients (OR 
      0.008, 95% CI 0.002 to 0.028; P<0.001). Simple linear regression analysis showed 
      a marked correlation between serum nesfatin-1 concentrations and body mass index 
      (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive 
      protein (CRP), and ankle-brachial index (ABI) in T2DM patients. By contrast, 
      multivariable analysis showed only BMI and ABI as independent correlates of serum 
      nesfatin-1. CONCLUSIONS: Our study shows an association of serum nesfatin-1 
      concentrations and the development and severity of PAD in T2DM patients.
FAU - Ding, Shimei
AU  - Ding S
AD  - Department of Endocrinology, Second Affiliated Hospital of Medical School of 
      Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
FAU - Qu, Wei
AU  - Qu W
AD  - Department of Nuclear Medicine, Second Affiliated Hospital of Medical School of 
      Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
FAU - Dang, Shuangsuo
AU  - Dang S
AD  - Department of Infectious Diseases, Second Affiliated Hospital of Medical School 
      of Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
FAU - Xie, Xuan
AU  - Xie X
AD  - Department of Endocrinology, Second Affiliated Hospital of Medical School of 
      Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
FAU - Xu, Jing
AU  - Xu J
AD  - Department of Endocrinology, Second Affiliated Hospital of Medical School of 
      Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
FAU - Wang, Yuhuan
AU  - Wang Y
AD  - Department of Endocrinology, Second Affiliated Hospital of Medical School of 
      Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
FAU - Jing, Aiyu
AU  - Jing A
AD  - Department of Endocrinology, Second Affiliated Hospital of Medical School of 
      Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
FAU - Zhang, Chunhong
AU  - Zhang C
AD  - Department of Endocrinology, Second Affiliated Hospital of Medical School of 
      Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
FAU - Wang, Junhong
AU  - Wang J
AD  - Department of Endocrinology, Second Affiliated Hospital of Medical School of 
      Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20150404
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NUCB2 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nucleobindins)
SB  - IM
MH  - Calcium-Binding Proteins/*blood
MH  - DNA-Binding Proteins/*blood
MH  - Diabetes Mellitus, Type 2/*blood/*complications
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*blood
MH  - Nucleobindins
MH  - Peripheral Arterial Disease/*blood/*complications
PMC - PMC4396685
EDAT- 2015/04/05 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/04/04
CRDT- 2015/04/05 06:00
PHST- 2015/04/05 06:00 [entrez]
PHST- 2015/04/05 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/04/04 00:00 [pmc-release]
AID - 892611 [pii]
AID - 10.12659/MSM.892611 [doi]
PST - epublish
SO  - Med Sci Monit. 2015 Apr 4;21:987-91. doi: 10.12659/MSM.892611.