PMID- 25841786
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20150423
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 594
DP  - 2015 May 6
TI  - Long-term effects of prenatal stress and diazepam on D2 receptor expression in 
      the nucleus accumbens of adult rats.
PG  - 133-6
LID - S0304-3940(15)00267-0 [pii]
LID - 10.1016/j.neulet.2015.03.065 [doi]
AB  - Early life stress during the gestational period alters specific neuronal circuits 
      leading to behavioral alterations later in life. In the present study, we 
      assessed the effects of prenatal stress and repeated benzodiazepine 
      administration on dopamine receptor 2 expression in the nucleus accumbens of 
      adult offspring. Our results show elevated Drd2 expression levels in the nucleus 
      accumbens (NAcc) of prenatally stressed rats compared to control subjects, while 
      repeated diazepam administration in adulthood down-regulated Drd2 expression and 
      prevented the effect of prenatal stress. These observations suggest that prenatal 
      stress may induce permanent alterations in the corticolimbic pathway implicated 
      in drug-seeking behavior.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Lakehayli, S
AU  - Lakehayli S
AD  - Laboratory of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, 19 
      Rue Tarik Bnou Ziad, Casablanca, Morocco. Electronic address: 
      Lakehayli.sara@gmail.com.
FAU - Said, N
AU  - Said N
AD  - Laboratory of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, 19 
      Rue Tarik Bnou Ziad, Casablanca, Morocco.
FAU - Khachibi, M El
AU  - Khachibi ME
AD  - Genetics and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy of 
      Casablanca, 19 Rue Tarik Bnou Ziad, Casablanca, Morocco.
FAU - Ouahli, M El
AU  - Ouahli ME
AD  - Sultan My Slimane University, Fac Sciences & Tecniques Beni-Mellal, Life 
      Sciences, Morocco.
FAU - Nadifi, S
AU  - Nadifi S
AD  - Genetics and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy of 
      Casablanca, 19 Rue Tarik Bnou Ziad, Casablanca, Morocco.
FAU - Hakkou, F
AU  - Hakkou F
AD  - Laboratory of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, 19 
      Rue Tarik Bnou Ziad, Casablanca, Morocco.
FAU - Tazi, A
AU  - Tazi A
AD  - Laboratory of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, 19 
      Rue Tarik Bnou Ziad, Casablanca, Morocco.
LA  - eng
PT  - Journal Article
DEP - 20150401
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Receptors, Dopamine D2)
RN  - Q3JTX2Q7TU (Diazepam)
SB  - IM
MH  - Animals
MH  - Anti-Anxiety Agents/*pharmacology
MH  - Diazepam/*pharmacology
MH  - Female
MH  - Male
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Pregnancy
MH  - Pregnancy Complications/*metabolism/psychology
MH  - Rats, Wistar
MH  - Receptors, Dopamine D2/*metabolism
MH  - Stress, Psychological/*metabolism/psychology
MH  - Time Factors
OTO - NOTNLM
OT  - Diazepam
OT  - Drd2 expression
OT  - Mesocorticolimbic pathway
OT  - Nucleus accumbens
OT  - Prenatal stress
EDAT- 2015/04/07 06:00
MHDA- 2015/09/15 06:00
CRDT- 2015/04/06 06:00
PHST- 2015/02/13 00:00 [received]
PHST- 2015/03/27 00:00 [revised]
PHST- 2015/03/30 00:00 [accepted]
PHST- 2015/04/06 06:00 [entrez]
PHST- 2015/04/07 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
AID - S0304-3940(15)00267-0 [pii]
AID - 10.1016/j.neulet.2015.03.065 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 May 6;594:133-6. doi: 10.1016/j.neulet.2015.03.065. Epub 2015 
      Apr 1.