PMID- 25842203
OWN - NLM
STAT- MEDLINE
DCOM- 20151127
LR  - 20181113
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Print)
IS  - 1525-5050 (Linking)
VI  - 45
DP  - 2015 Apr
TI  - The Pediatric Epilepsy Side Effects Questionnaire: Establishing clinically 
      meaningful change.
PG  - 101-4
LID - S1525-5050(15)00119-5 [pii]
LID - 10.1016/j.yebeh.2015.03.014 [doi]
AB  - The present study extends the utility of the Pediatric Epilepsy Side Effects 
      Questionnaire (PESQ) by determining distribution-based minimally clinically 
      important difference (MCID) scores. Participants (N=682) were youth (ages 2-25) 
      with newly diagnosed and chronic epilepsy pooled from research and clinical data 
      in the Comprehensive Epilepsy Center. Caregivers completed the PESQ. Demographic 
      and medical data were extracted from medical chart reviews or via a 
      questionnaire. The MCIDs, which are the standard errors of measurement for each 
      scale, for the entire sample were as follows: Cognitive=4.66, Motor=4.67, 
      Behavior=8.05, General Neurological=7.41, Weight=9.58, and Total Side 
      Effects=3.25. Additionally, MCIDs for patients with new-onset (<12months) 
      epilepsy on monotherapy, new-onset epilepsy on polytherapy, chronic epilepsy on 
      monotherapy (>12months), and chronic epilepsy on polytherapy were calculated. 
      Results from the present study extend the utility of the PESQ by providing 
      clinicians and researchers an enhanced understanding about clinically meaningful 
      changes in side effect profiles across the pediatric epilepsy spectrum. These 
      data can inform clinical decision-making for clinicians and researchers.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Junger, Katherine W
AU  - Junger KW
AD  - Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's 
      Hospital Medical Center, University of Cincinnati College of Medicine, USA. 
      Electronic address: katherine.junger@cchmc.org.
FAU - Morita, Diego
AU  - Morita D
AD  - Division of Neurology, Cincinnati Children's Hospital Medical Center, University 
      of Cincinnati College of Medicine, USA. Electronic address: 
      diego.morita@cchmc.org.
FAU - Modi, Avani C
AU  - Modi AC
AD  - Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's 
      Hospital Medical Center, University of Cincinnati College of Medicine, USA. 
      Electronic address: avani.modi@cchmc.org.
LA  - eng
GR  - K23 HD057333/HD/NICHD NIH HHS/United States
GR  - K23HD057333/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150401
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/*adverse effects/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Drug-Related Side Effects and Adverse Reactions/diagnosis
MH  - Epilepsy/*diagnosis/*drug therapy
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Surveys and Questionnaires/standards
MH  - Young Adult
PMC - PMC4424120
MID - NIHMS673299
OTO - NOTNLM
OT  - Antiepileptic drugs
OT  - Children
OT  - MCID
OT  - Patient-reported outcome
OT  - Seizures
OT  - Side effects
COIS- Disclosures, Conflicts of Interests Financial Disclosures: Drs. Avani Modi, 
      Katherine Junger, and Diego Morita report no disclosures.
EDAT- 2015/04/07 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/04/01
CRDT- 2015/04/06 06:00
PHST- 2015/01/23 00:00 [received]
PHST- 2015/03/10 00:00 [revised]
PHST- 2015/03/11 00:00 [accepted]
PHST- 2015/04/06 06:00 [entrez]
PHST- 2015/04/07 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - S1525-5050(15)00119-5 [pii]
AID - 10.1016/j.yebeh.2015.03.014 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2015 Apr;45:101-4. doi: 10.1016/j.yebeh.2015.03.014. Epub 2015 
      Apr 1.