PMID- 25843245
OWN - NLM
STAT- MEDLINE
DCOM- 20160421
LR  - 20150605
IS  - 1096-3618 (Electronic)
IS  - 1044-5323 (Linking)
VI  - 27
IP  - 2
DP  - 2015 Mar
TI  - Dendritic cell functions: Learning from microbial evasion strategies.
PG  - 119-24
LID - S1044-5323(15)00020-2 [pii]
LID - 10.1016/j.smim.2015.03.012 [doi]
AB  - Dendritic cells (DCs) are specialized antigen presenting cells (APC) that are 
      fundamental to initiate both immunity and tolerance. DCs play a 'sentinel' role 
      to protect our body from potential pathogens and induce tolerogenic responses 
      toward harmless antigens. The flexibility of DCs or macrophages to adapt to the 
      environment and to respond accordingly can be hijacked by pathogens for their own 
      interest to transform a potentially immunogenic APC into a tolerogenic cell with 
      clear consequences in pathogen clearance. While these immune evasion mechanisms 
      can be detrimental for the host, they can highlight important molecular pathways 
      in DCs necessary for their function. In this review we will mention several 
      mechanisms employed by pathogens to evade DC patrolling function.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Rescigno, Maria
AU  - Rescigno M
AD  - Department of Experimental Oncology, European Institute of Oncology, Milan, 
      Italy; Department of Health Sciences, School of Medicine, University of Milan, 
      Milan, Italy. Electronic address: maria.rescigno@ieo.eu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150402
PL  - England
TA  - Semin Immunol
JT  - Seminars in immunology
JID - 9009458
SB  - IM
MH  - Animals
MH  - Bacteria/immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immune Evasion
MH  - Immune Tolerance
MH  - Macrophages/immunology
MH  - Phagocytosis
MH  - T-Lymphocytes/immunology
OTO - NOTNLM
OT  - Dendritic cells
OT  - Immune evasion
OT  - Pathogens
OT  - Tolerance
EDAT- 2015/04/07 06:00
MHDA- 2016/04/22 06:00
CRDT- 2015/04/07 06:00
PHST- 2015/03/17 00:00 [received]
PHST- 2015/03/17 00:00 [accepted]
PHST- 2015/04/07 06:00 [entrez]
PHST- 2015/04/07 06:00 [pubmed]
PHST- 2016/04/22 06:00 [medline]
AID - S1044-5323(15)00020-2 [pii]
AID - 10.1016/j.smim.2015.03.012 [doi]
PST - ppublish
SO  - Semin Immunol. 2015 Mar;27(2):119-24. doi: 10.1016/j.smim.2015.03.012. Epub 2015 
      Apr 2.