PMID- 25843933
OWN - NLM
STAT- MEDLINE
DCOM- 20160209
LR  - 20150513
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1610
DP  - 2015 Jun 12
TI  - Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 
      synthesis in the rat.
PG  - 61-8
LID - S0006-8993(15)00278-4 [pii]
LID - 10.1016/j.brainres.2015.03.043 [doi]
AB  - Caloric restriction (CR) has been shown to have several health benefits and 
      provides protection against type 2 diabetes, neurodegenerative and cerebral 
      vascular diseases. It reduces the brain infarct size and promotes neurological 
      functional recovery after cerebral ischemia. Sirtuin 1 (SIRT1) plays an important 
      role in the biological effects induced by CR. This study investigated the role of 
      SIRT1 in ischemic tolerance in the brain induced by CR. Sprague drawly rats were 
      divided into two groups based on food intake. Ad libitum (AL) group was fed with 
      normal diet while the CR group received 60% calories compared to AL. All animals 
      were subjected to a middle cerebral artery occlusion for 90 min. Results showed 
      the neurological function score of CR group was higher and the brain infarct 
      volume was markedly reduced in CR group compared to AL group at 24h after 
      reperfusion (p < 0.05). CR increased the synthesis of SIRT1 significantly (p < 
      0.05), and ameliorated the down regulation of SIRT1 expression at 6 and 12h after 
      middle cerebral artery occlusion (p < 0.05, p < 0 .01, respectively). Knockdown 
      of SIRT1 by siRNA in vivo reversed the neuroprotective effect of CR. From this 
      study, we deduce that CR induces brain ischemic tolerance on rats via increasing 
      the synthesis of SIRT1.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Ran, Mingzi
AU  - Ran M
AD  - Department of Anesthesiology, Xijing Hospital, Fourth Military Medical 
      University, 127 Changle West Road, Xi'an 710032, Shaanxi, China. Electronic 
      address: Ranmingzi1989@foxmail.com.
FAU - Li, Zhaoju
AU  - Li Z
AD  - Department of Anesthesiology, General Hospital of Guangzhou Military Command of 
      PLA, 111 Liuhua Road, Guangzhou 510010, Guangdong, China. Electronic address: 
      hellenanna@163.com.
FAU - Yang, Lujia
AU  - Yang L
AD  - Department of Anesthesiology, Chinese PLA General Hospital, 28 Fuxing Road, 
      Beijing 100853, China. Electronic address: Lukehome@me.com.
FAU - Tong, Li
AU  - Tong L
AD  - Department of Anesthesiology, Xijing Hospital, Fourth Military Medical 
      University, 127 Changle West Road, Xi'an 710032, Shaanxi, China. Electronic 
      address: tongli@fmmu.edu.cn.
FAU - Zhang, Lina
AU  - Zhang L
AD  - Department of Anesthesiology, Xijing Hospital, Fourth Military Medical 
      University, 127 Changle West Road, Xi'an 710032, Shaanxi, China. Electronic 
      address: 15891755136@163.com.
FAU - Dong, Hailong
AU  - Dong H
AD  - Department of Anesthesiology, Xijing Hospital, Fourth Military Medical 
      University, 127 Changle West Road, Xi'an 710032, Shaanxi, China. Electronic 
      address: hldong6@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150403
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Blood Glucose)
RN  - 0 (RNA, Small Interfering)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Blotting, Western
MH  - Body Weight
MH  - Brain/metabolism/pathology
MH  - Brain Ischemia/*diet therapy/*metabolism/pathology
MH  - *Caloric Restriction
MH  - Disease Models, Animal
MH  - Fluorescent Antibody Technique
MH  - Gene Knockdown Techniques
MH  - Infarction, Middle Cerebral Artery
MH  - Male
MH  - RNA, Small Interfering
MH  - Rats, Sprague-Dawley
MH  - Real-Time Polymerase Chain Reaction
MH  - Reperfusion Injury/diet therapy/metabolism/pathology
MH  - Severity of Illness Index
MH  - Sirtuin 1/genetics/*metabolism
OTO - NOTNLM
OT  - Brain ischemic tolerance
OT  - Calorie restriction
OT  - Neuroprotection
OT  - SIRT1
EDAT- 2015/04/07 06:00
MHDA- 2016/02/10 06:00
CRDT- 2015/04/07 06:00
PHST- 2014/06/29 00:00 [received]
PHST- 2014/11/10 00:00 [revised]
PHST- 2015/03/23 00:00 [accepted]
PHST- 2015/04/07 06:00 [entrez]
PHST- 2015/04/07 06:00 [pubmed]
PHST- 2016/02/10 06:00 [medline]
AID - S0006-8993(15)00278-4 [pii]
AID - 10.1016/j.brainres.2015.03.043 [doi]
PST - ppublish
SO  - Brain Res. 2015 Jun 12;1610:61-8. doi: 10.1016/j.brainres.2015.03.043. Epub 2015 
      Apr 3.