PMID- 25844530
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20220321
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 93
IP  - 6
DP  - 2015 Jun
TI  - Endurance training alters basal erythrocyte MCT-1 contents and affects the 
      lactate distribution between plasma and red blood cells in T2DM men following 
      maximal exercise.
PG  - 413-9
LID - 10.1139/cjpp-2014-0467 [doi]
AB  - Chronic elevated lactate levels are associated with insulin resistance in 
      patients with type 2 diabetes mellitus (T2DM). Furthermore, lactacidosis plays a 
      role in limiting physical performance. Erythrocytes, which take up lactate via 
      monocarboxylate transporter (MCT) proteins, may help transport lactate within the 
      blood from lactate-producing to lactate-consuming organs. This study investigates 
      whether cycling endurance training (3 times/week for 3 months) alters the basal 
      erythrocyte content of MCT-1, and whether it affects lactate distribution 
      kinetics in the blood of T2DM men (n = 10, years = 61 +/- 9, body mass index = 31 +/- 
      3 kg/m(2)) following maximal exercise (WHO step-incremental cycle ergometer 
      test). Immunohistochemical staining indicated that basal erythrocyte contents of 
      MCT-1 protein were up-regulated (+90%, P = 0.011) post-training. Erythrocyte and 
      plasma lactate increased from before acute exercise (= resting values) to 
      physical exhaustion pre- as well as post-training (pre-training: +309%, P = 
      0.004; +360%, P < 0.001; post-training: +318%, P = 0.008; +300%, P < 0.001), and 
      did not significantly decrease during 5 min recovery. The lactate ratio 
      (erythrocytes:plasma) remained unchanged after acute exercise pre-training, but 
      was significantly increased after 5 min recovery post-training (compared with the 
      resting value) (+22%, P = 0.022). The results suggest an increased time-delayed 
      influx of lactate into erythrocytes following an acute bout of exercise in 
      endurance-trained diabetic men.
FAU - Opitz, David
AU  - Opitz D
AD  - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular 
      Research and Sport Medicine, German Sport University Cologne, Am Sportpark 
      Mungersdorf 6, 50933 Cologne, Germany.
FAU - Lenzen, Edward
AU  - Lenzen E
FAU - Opiolka, Andreas
AU  - Opiolka A
FAU - Redmann, Melanie
AU  - Redmann M
FAU - Hellmich, Martin
AU  - Hellmich M
FAU - Bloch, Wilhelm
AU  - Bloch W
FAU - Brixius, Klara
AU  - Brixius K
FAU - Brinkmann, Christian
AU  - Brinkmann C
LA  - eng
PT  - Journal Article
DEP - 20150130
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Monocarboxylic Acid Transporters)
RN  - 0 (Symporters)
RN  - 0 (monocarboxylate transport protein 1)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
EIN - Can J Physiol Pharmacol. 2019 May;97(5):440. PMID: 30990739
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Erythrocytes/*metabolism
MH  - Exercise/physiology
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Lactic Acid/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Monocarboxylic Acid Transporters/*metabolism
MH  - Physical Endurance/*physiology
MH  - Plasma/*metabolism
MH  - Symporters/*metabolism
MH  - Up-Regulation/physiology
OTO - NOTNLM
OT  - RBC
OT  - diabete de type 2
OT  - monocarboxylate transporter
OT  - transporteur de monocarboxylate
OT  - type 2 diabetes
OT  - erythrocytes
EDAT- 2015/04/07 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/04/07 06:00
PHST- 2015/04/07 06:00 [entrez]
PHST- 2015/04/07 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - 10.1139/cjpp-2014-0467 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2015 Jun;93(6):413-9. doi: 10.1139/cjpp-2014-0467. Epub 
      2015 Jan 30.