PMID- 25844609
OWN - NLM
STAT- MEDLINE
DCOM- 20151229
LR  - 20150407
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Apr
TI  - Study of human leukocyte antigen-cw in Egyptian patients with vitiligo.
PG  - 359-64
AB  - Human leukocyte antigen (HLA) antigens vary considerably in different racial 
      groups, and an analysis of results from several geographical locations suggests 
      that vitiligo appears to be associated with different HLA antigens in different 
      groups. The aim of this work was to assess the association of HLA-Cw with 
      vitiligo in the Egyptian population. Forty unrelated patients with nonsegmental 
      vitiligo and 20 matched controls were selected. A polymerase chain reaction 
      sequence specific primer (PCR-SSP) method was used to determine HLA DNA typing. 
      There was a statistically significant difference in the association of HLA-Cw6 
      with vitiligo in the 2 studied groups. A comparatively increased number of 
      patients showed HLA-Cw2 and HLA-Cw7 (13.64%). However, there were no 
      statistically significant differences. To the best of our knowledge, this is the 
      first molecular study of HLA typing in Egyptian patients with vitiligo. Our 
      findings are in agreement with earlier studies that reported statistically 
      increased frequencies for allele of HLA-Cw6 in Northern Italian, Kuwaiti, Chinese 
      Han, and Saudi populations (45.45%, P<.05).
FAU - Hassab El Naby, Hussein M
AU  - Hassab El Naby HM
FAU - Alnaggar, Mohamed R
AU  - Alnaggar MR
FAU - Abdelhamid, Mahmoud F
AU  - Abdelhamid MF
FAU - Alsaid, Khadiga
AU  - Alsaid K
FAU - Al Shawadfy, Eslam M
AU  - Al Shawadfy EM
FAU - Elsaie, Mohamed L
AU  - Elsaie ML
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*02 antigen)
RN  - 0 (HLA-C*06 antigen)
RN  - 0 (HLA-C*70 antigen)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Alleles
MH  - Child
MH  - Egypt/epidemiology
MH  - Gene Frequency
MH  - HLA-C Antigens/*genetics
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Vitiligo/epidemiology/*genetics
EDAT- 2015/04/07 06:00
MHDA- 2015/12/30 06:00
CRDT- 2015/04/07 06:00
PHST- 2015/04/07 06:00 [entrez]
PHST- 2015/04/07 06:00 [pubmed]
PHST- 2015/12/30 06:00 [medline]
AID - S1545961615P0359X [pii]
PST - ppublish
SO  - J Drugs Dermatol. 2015 Apr;14(4):359-64.