PMID- 25845749
OWN - NLM
STAT- MEDLINE
DCOM- 20151207
LR  - 20221207
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 179
DP  - 2015 Jul 1
TI  - Association between HLA-DRB1*0405, -DQB1*0401 and -DQA1*0303 alleles and 
      lamotrigine-induced cutaneous adverse drug reactions. A pilot case-control study 
      from Japan.
PG  - 47-50
LID - S0165-0327(15)00148-2 [pii]
LID - 10.1016/j.jad.2015.03.018 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) genotypes in lamotrigine -induced 
      (LTG-induced) cutaneous adverse drug reactions (cADRs) have been described in 
      several reports but controversy remains even for a given ethnic group. We 
      attempted to clarify a possible association between LTG-induced cADRs and HLA 
      alleles in Japanese patients. METHOD: Sixteen subjects, including eight patients 
      with LTG-induced cADRs and eight LTG-tolerant controls were included in this 
      study. All eight patients with LTG-induced cADRs gave positive results in a 
      drug-induced lymphocyte stimulation test (DLST) with LTG. We performed HLA-typing 
      for HLA-A, -B, -C, -DRB1, -DQA1, -DQB1, -DPA1 and -DPB1, using PCR with 
      sequence-specific oligonucleotide probes and multiple analyte profiling (xMAP) 
      technology (Luminex System; Luminex Corporation, Austin, TX). We examined 
      differences between allele frequencies in our two groups of subjects and the 
      allele frequencies in the general Japanese population. RESULTS: The frequencies 
      of HLA-DRB1*0405, and HLA-DQB1*0401 alleles were higher in our LTG-cADRs patients 
      than the reference frequencies in the general Japanese population. We also 
      detected HLA-DQA1*0303 frequently in our LTG-cADRs patients, but data for this 
      allele in the Japanese population was not available. Our observation was 
      presumably due to the linkage disequilibrium among the three alleles. The 
      haplotype frequency of HLA-DRB1*0405, DQB1*0401 and DQA1*0303 in our LTG-cADRs 
      subjects was also different from the corresponding haplotype frequency in the 
      database for the Japanese population and the difference was statistically 
      significant. One patient with the HLA-DRB1*0405, -DQB1*0401 and DQA1*0303 
      haplotype was safely re-treated with LTG after results of a DLST with LTG ceased 
      to be positive about 4 months after discontinuation of LTG. LIMITATIONS: Our 
      analysis included only 16 patients. Associations between LTG-induced cADRs and 
      specific HLA loci will have to be confirmed in larger studies. CONCLUSIONS: 
      LTG-induced cADRs are associated with HLA-DRB1*0405, -DQB1*0401 and -DQA1*0303.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Ito, Akiko
AU  - Ito A
AD  - Department of Dermatology, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Shimada, Hiromitsu
AU  - Shimada H
AD  - Department of Dermatology, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Ishikawa, Kazushi
AU  - Ishikawa K
AD  - Department of Dermatology, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Takeo, Naoko
AU  - Takeo N
AD  - Department of Dermatology, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Hatano, Yutaka
AU  - Hatano Y
AD  - Department of Dermatology, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Katagiri, Kazumoto
AU  - Katagiri K
AD  - Department of Dermatology, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Kohno, Kentaro
AU  - Kohno K
AD  - Department of Neuropsychiatry, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Araki, Yasuo
AU  - Araki Y
AD  - Department of Neuropsychiatry, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Terao, Takeshi
AU  - Terao T
AD  - Department of Neuropsychiatry, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Kojima, Hiroto
AU  - Kojima H
AD  - HLA Foundation Laboratory, Kyoto, Japan.
FAU - Terao, Chikashi
AU  - Terao C
AD  - Unit of Human Disease Genomics, Center for Genomic Medicine, Kyoto University 
      Graduate School of Medicine, Kyoto, Japan.
FAU - Eshima, Nobuoki
AU  - Eshima N
AD  - Department of Biostatistics, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan.
FAU - Fujiwara, Sakuhei
AU  - Fujiwara S
AD  - Department of Dermatology, Faculty of Medicine, Oita University, Hasama, Yufu 
      879-5593, Japan. Electronic address: fujiwara@oita-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150320
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:05 antigen)
RN  - 0 (Triazines)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ alpha-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Japan
MH  - Lamotrigine
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Triazines/*adverse effects
OTO - NOTNLM
OT  - Cutaneous adverse drug reactions
OT  - Drug lymphocyte stimulation test
OT  - Human leukocyte antigen
OT  - Lamotrigine
OT  - MHC class II antigen
EDAT- 2015/04/08 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/04/08 06:00
PHST- 2014/12/25 00:00 [received]
PHST- 2015/03/06 00:00 [revised]
PHST- 2015/03/12 00:00 [accepted]
PHST- 2015/04/08 06:00 [entrez]
PHST- 2015/04/08 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0165-0327(15)00148-2 [pii]
AID - 10.1016/j.jad.2015.03.018 [doi]
PST - ppublish
SO  - J Affect Disord. 2015 Jul 1;179:47-50. doi: 10.1016/j.jad.2015.03.018. Epub 2015 
      Mar 20.