PMID- 25845934
OWN - NLM
STAT- MEDLINE
DCOM- 20151006
LR  - 20161125
IS  - 1879-1220 (Electronic)
IS  - 0960-0760 (Linking)
VI  - 152
DP  - 2015 Aug
TI  - A review of 1alpha,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a 
      non-canonical pathway signaling.
PG  - 84-8
LID - S0960-0760(15)00099-0 [pii]
LID - 10.1016/j.jsbmb.2015.04.002 [doi]
AB  - Wnt5a and 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] regulate endochondral 
      ossification. 1alpha,25(OH)2D3 initiates its calcium-dependent effects via its 
      membrane-associated receptor, protein disulfide isomerase A3 (Pdia3). 
      1alpha,25(OH)2D3 binding to Pdia3 triggers the interaction between Pdia3 and 
      phospholipase A2 (PLA2)-activating protein (PLAA), resulting in downstream 
      activation of calcium/calmodulin-dependent protein kinase II (CaMKII), PLA2, and 
      protein kinase C (PKC). Wnt5a initiates its calcium-dependent effects via binding 
      its receptors Frizzled2 (FZD2) and Frizzled5 (FZD5) and receptor tyrosine 
      kinase-like orphan receptor 2 (ROR2), activating intracellular calcium release 
      and stimulating PKC and CaMKII. Recent efforts to determine the inter-relation 
      between Wnt5a and 1alpha,25(OH)2D3 signaling pathways have demonstrated that Wnt5a 
      signals through a CaMKII/PLA2/PGE2/PKC cascade in chondrocytes and osteoblasts in 
      which the components of the Pdia3 receptor complex were required. Furthermore, 
      ROR2, but not FZD2 or FZD5, was required to mediate the calcium-dependent actions 
      of 1alpha,25(OH)2D3. This review provides evidence that 1alpha,25(OH)2D3 and Wnt5a 
      mediate their calcium-dependent pathways via similar receptor components and 
      proposes that these pathways may interact since they are competing for the same 
      receptor complex components.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Doroudi, Maryam
AU  - Doroudi M
AD  - School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
FAU - Olivares-Navarrete, Rene
AU  - Olivares-Navarrete R
AD  - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 
      VA 23284, USA.
FAU - Boyan, Barbara D
AU  - Boyan BD
AD  - School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA; 
      Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 
      VA 23284, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia 
      Institute of Technology, Atlanta, GA 30332, USA. Electronic address: 
      bboyan@vcu.edu.
FAU - Schwartz, Zvi
AU  - Schwartz Z
AD  - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 
      VA 23284, USA; Department of Periodontics, The University of Texas Health Science 
      Center at San Antonio, San Antonio, TX 78284, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150403
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (Frizzled Receptors)
RN  - 0 (Fzd2 protein, mouse)
RN  - 0 (Fzd5 protein, mouse)
RN  - 0 (Proteins)
RN  - 0 (Wnt Proteins)
RN  - 0 (Wnt-5a Protein)
RN  - 0 (Wnt5a protein, mouse)
RN  - 0 (phospholipase A2-activating protein)
RN  - EC 2.7.10.1 (Receptor Tyrosine Kinase-like Orphan Receptors)
RN  - EC 2.7.10.1 (Ror2 protein, mouse)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 5.3.4.1 (Pdia3 protein, mouse)
RN  - EC 5.3.4.1 (Protein Disulfide-Isomerases)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Animals
MH  - Calcitriol/*metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism
MH  - Cell Line
MH  - Frizzled Receptors/metabolism
MH  - Humans
MH  - Mice
MH  - Protein Disulfide-Isomerases/*metabolism
MH  - Protein Kinase C/metabolism
MH  - Proteins/metabolism
MH  - Receptor Tyrosine Kinase-like Orphan Receptors/metabolism
MH  - Wnt Proteins/*metabolism
MH  - Wnt Signaling Pathway/*physiology
MH  - Wnt-5a Protein
OTO - NOTNLM
OT  - 1,25-Dihydroxyvitamin D3
OT  - Calmodulin
OT  - Phospholipase A2 activating protein
OT  - Protein disulfide isomerase A3
OT  - Protein kinase C
OT  - Wnt5a
EDAT- 2015/04/08 06:00
MHDA- 2015/10/07 06:00
CRDT- 2015/04/08 06:00
PHST- 2014/09/12 00:00 [received]
PHST- 2015/03/16 00:00 [revised]
PHST- 2015/04/02 00:00 [accepted]
PHST- 2015/04/08 06:00 [entrez]
PHST- 2015/04/08 06:00 [pubmed]
PHST- 2015/10/07 06:00 [medline]
AID - S0960-0760(15)00099-0 [pii]
AID - 10.1016/j.jsbmb.2015.04.002 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2015 Aug;152:84-8. doi: 10.1016/j.jsbmb.2015.04.002. 
      Epub 2015 Apr 3.