PMID- 25847302
OWN - NLM
STAT- MEDLINE
DCOM- 20160203
LR  - 20220331
IS  - 1879-3150 (Electronic)
IS  - 0041-0101 (Linking)
VI  - 100
DP  - 2015 Jun 15
TI  - A forward to optimization of antivenom therapy: An in vivo study upon the 
      effectiveness of the antivenom against early and delayed nephrotoxicity induced 
      by the venom of the Iranian scorpion Hemiscorpius lepturus in rat.
PG  - 13-9
LID - S0041-0101(15)00091-4 [pii]
LID - 10.1016/j.toxicon.2015.03.023 [doi]
AB  - The aim of the present in vivo study was to identify the optimal effective dose, 
      the most favorable time and the route of administration of the available 
      polyvalent scorpion antivenom against the toxic effects induced by Hemiscorpius 
      lepturus (H. lepturus) venom in rat. The end point for assessment included 
      measurement of alanin-amino-peptidase (AAP) and N-acetyl-b-d-glucosaminidase 
      (NAG), biochemical urine analysis and histopathological assessment. The results 
      showed that a single subcutaneous 50 mug of the venom produced significant 
      increase in the AAP and NAG enzyme activity, urinary biochemical parameters and 
      induced histopathological structural abnormalities in the renal system. The 
      optimal effective co-administered dose of the antivenom was 0.5 ml, which when 
      administered 1 and 2 h of envenomation by intravenous (IV) and subcutaneous (SC) 
      routes respectively produced significant protection against these toxic effects. 
      Prudently, the significance of these findings need to be assessed in further 
      clinical studies.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Pipelzadeh, Mohammad Hassan
AU  - Pipelzadeh MH
AD  - Department of Pharmacology, Faculty of Medicine and Toxicology Research Center, 
      Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Jalali, Amir
AU  - Jalali A
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy and Toxicology 
      Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran. 
      Electronic address: amjalali@hotmail.com.
FAU - Dezfulian, Abdul Rahman
AU  - Dezfulian AR
AD  - Department of Anatomy and Histology, Dezful Medical School, Dezful, Iran.
FAU - Khorasgani, Zahra Nazari
AU  - Khorasgani ZN
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy and Toxicology 
      Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Sarvestani, Somie
AU  - Sarvestani S
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy and Toxicology 
      Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Ghalambor, Amir Hossein
AU  - Ghalambor AH
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy and Toxicology 
      Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Azarpanah, Armita
AU  - Azarpanah A
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy and Toxicology 
      Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150403
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Antivenins)
RN  - 0 (Biomarkers)
RN  - 0 (Scorpion Venoms)
RN  - EC 3.2.1.52 (Acetylglucosaminidase)
RN  - EC 3.4.- (Peptide Hydrolases)
SB  - IM
MH  - Acetylglucosaminidase/urine
MH  - Animals
MH  - Antivenins/*administration & dosage/therapeutic use
MH  - Biomarkers/urine
MH  - Hemoglobinuria
MH  - Kidney/drug effects/pathology
MH  - Male
MH  - Peptide Hydrolases/urine
MH  - Proteinuria
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Scorpion Stings/*drug therapy
MH  - Scorpion Venoms/*toxicity
MH  - Time Factors
OTO - NOTNLM
OT  - Alanin Amino Peptidase (AAP)
OT  - Hemiscorpius lepturus
OT  - In-vivo
OT  - N-Acetyl-beta-d-Glucosaminidase (NAG)
OT  - Nephrotoxicity
OT  - Polyvalent antivenom
EDAT- 2015/04/08 06:00
MHDA- 2016/02/04 06:00
CRDT- 2015/04/08 06:00
PHST- 2014/10/17 00:00 [received]
PHST- 2015/02/07 00:00 [revised]
PHST- 2015/03/31 00:00 [accepted]
PHST- 2015/04/08 06:00 [entrez]
PHST- 2015/04/08 06:00 [pubmed]
PHST- 2016/02/04 06:00 [medline]
AID - S0041-0101(15)00091-4 [pii]
AID - 10.1016/j.toxicon.2015.03.023 [doi]
PST - ppublish
SO  - Toxicon. 2015 Jun 15;100:13-9. doi: 10.1016/j.toxicon.2015.03.023. Epub 2015 Apr 
      3.