PMID- 25848236
OWN - NLM
STAT- MEDLINE
DCOM- 20151127
LR  - 20181113
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Print)
IS  - 1176-9092 (Linking)
VI  - 10
DP  - 2015
TI  - Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in 
      sarcopenic obesity.
PG  - 605-9
LID - 10.2147/CIA.S78901 [doi]
AB  - OBJECTIVE: Sarcopenic obesity (SO) is associated with poorer physical outcomes 
      and functional status in the older adult. A proinflammatory milieu associated 
      with central obesity is postulated to enhance muscle catabolism. We set out to 
      examine associations of the chemokine monocyte chemoattractant protein-1 (MCP-1) 
      in groups of older adults, with sarcopenia, obesity, and the SO phenotypes. 
      METHODS: A total of 143 community dwelling, well, older adults were recruited. 
      Cross-sectional clinical data, physical performance, and muscle mass measurements 
      were collected. Obesity and sarcopenia were defined using revised National 
      Cholesterol Education Program (NCEP) obesity guidelines and those of the Asian 
      Working Group for Sarcopenia. Serum levels of MCP-1 were measured by 
      enzyme-linked immunosorbent assay (ELISA). RESULTS: In all, 25.2% of subjects 
      were normal, 15.4% sarcopenic, 48.3% obese, and 11.2% were SO. The SO groups had 
      the lowest appendicular lean mass, highest percentage body fat, and lowest 
      performance scores on the Short Physical Performance Battery and grip strength. 
      The MCP-1 levels were significantly different, with the highest levels found in 
      SO participants (P<0.05). CONCLUSION: Significantly raised MCP-1 levels in obese 
      and SO subjects support the theory of chronic inflammation due to excess 
      adiposity. Longitudinal studies will reveal whether SO represents a continuum of 
      obesity causing accelerated sarcopenia and cardiovascular events, or the 
      coexistence of two separate conditions with synergistic effects affecting 
      functional performance.
FAU - Lim, Jun Pei
AU  - Lim JP
AD  - Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore ; Institute 
      of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.
FAU - Leung, Bernard P
AU  - Leung BP
AD  - Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 
      Singapore.
FAU - Ding, Yew Yoong
AU  - Ding YY
AD  - Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore ; Institute 
      of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.
FAU - Tay, Laura
AU  - Tay L
AD  - Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore ; Institute 
      of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.
FAU - Ismail, Noor Hafizah
AU  - Ismail NH
AD  - Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore ; 
      Department of Community and Continuing Care, Tan Tock Seng Hospital, Singapore.
FAU - Yeo, Audrey
AU  - Yeo A
AD  - Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.
FAU - Yew, Suzanne
AU  - Yew S
AD  - Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.
FAU - Chong, Mei Sian
AU  - Chong MS
AD  - Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore ; Institute 
      of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150325
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Chemokine CCL2/*blood
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hand Strength
MH  - Humans
MH  - Male
MH  - Obesity/*blood/complications
MH  - Physical Fitness/physiology
MH  - Sarcopenia/*blood/complications
PMC - PMC4378871
OTO - NOTNLM
OT  - chemokine C-C motif ligand 2 (CCL-2)
OT  - elderly
OT  - sarcopenia
EDAT- 2015/04/08 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/03/25
CRDT- 2015/04/08 06:00
PHST- 2015/04/08 06:00 [entrez]
PHST- 2015/04/08 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/03/25 00:00 [pmc-release]
AID - cia-10-605 [pii]
AID - 10.2147/CIA.S78901 [doi]
PST - epublish
SO  - Clin Interv Aging. 2015 Mar 25;10:605-9. doi: 10.2147/CIA.S78901. eCollection 
      2015.