PMID- 25848840
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20220410
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 41
IP  - 1
DP  - 2016
TI  - Increased Serum Chemerin Levels in Diabetic Retinopathy of Type 2 Diabetic 
      Patients.
PG  - 114-20
LID - 10.3109/02713683.2015.1004718 [doi]
AB  - PURPOSE: To compare serum levels of chemerin in type 2 diabetes mellitus (T2DM) 
      with or without retinopathy, and to investigate the relationship between serum 
      chemerin levels and diabetes retinopathy. MATERIALS AND METHODS: A total of 60 
      T2DM patients and 20 healthy subjects (control group) were enrolled in this 
      study. Of the T2DM patients, 15 had proliferative diabetic retinopathy (PDR 
      group), 20 had non-proliferative retinopathy (NPDR group) and 25 had no 
      retinopathy (T2DM group). Their serum samples were collected for testing the 
      levels of chemerin, vascular endothelial growth factor (VEGF), C-reactive protein 
      (CRP) and so on. The values were analyzed to compare the differences among the 
      groups. Simple linear regression analysis and multiple stepwise linear regression 
      analysis were used to determine the correlations between variables and chemerin. 
      Trend chi-square was used to determine the correlations between chemerin and the 
      severity of diabetic retinopathy (DR). RESULTS: Chemerin levels in group PDR, 
      NPDR and no DR were 147.56 +/- 35.98 mug/l, 128.09 +/- 16.33 mug/l and 
      113.19 +/- 19.89 mug/l, with the significant difference across the three groups 
      (p < 0.05). But there was no difference between control group 
      (109.55 +/- 20.98 mug/l) and T2DM group. Simple linear regression show that serum 
      chemerin was correlated with duration of diabetes, body mass index (BMI), serum 
      triglycerides, total-cholesterol, CRP and VEGF, and not correlated with age, 
      systolic and diastolic blood pressure in T2DM patients. Stepwise regression 
      analysis showed that BMI, CRP and VEGF were significantly associated with serum 
      chemerin (p = 0.006, p = 0.011 and p = 0.036, respectively). In addition, the 
      more severity of DR as the chemerin levels increased (chi(2) = 16.07, p < 0.001). 
      CONCLUSIONS: Serum levels of chemerin were significantly increased in the NPDR 
      and PDR group. Elevated serum level of chemerin and its positive correlation with 
      BMI, CRP and VEGF suggested that chemerin was associated with obesity, 
      inflammation and neovascularization and might be involved in the development of 
      DR.
FAU - Du, Junhui
AU  - Du J
AD  - a Key Laboratory of Environment and Genes Related to Diseases , Ministry of 
      Education, School of Medicine, Xi'an Jiaotong University , Xi'an , Shaanxi , 
      China .
AD  - b Department of Ophthalmology , Xi'an Ninth Hospital Affiliated to Medical 
      College of Xi'an Jiaotong University , Xi'an , Shaanxi , China .
FAU - Li, Rong
AU  - Li R
AD  - c Department of Ophthalmology , The Affiliated Hospital of Xi'an Medical 
      University , Xi'an , Shaanxi , China and.
FAU - Xu, Lin
AU  - Xu L
AD  - d Department of Endocrinology , The Affiliated Guangren Hospital of Xi'an 
      Jiaotong University College of Medicine , Xi'an , Shaanxi , China.
FAU - Ma, Ranran
AU  - Ma R
AD  - a Key Laboratory of Environment and Genes Related to Diseases , Ministry of 
      Education, School of Medicine, Xi'an Jiaotong University , Xi'an , Shaanxi , 
      China .
FAU - Liu, Jiali
AU  - Liu J
AD  - a Key Laboratory of Environment and Genes Related to Diseases , Ministry of 
      Education, School of Medicine, Xi'an Jiaotong University , Xi'an , Shaanxi , 
      China .
FAU - Cheng, Jing
AU  - Cheng J
AD  - b Department of Ophthalmology , Xi'an Ninth Hospital Affiliated to Medical 
      College of Xi'an Jiaotong University , Xi'an , Shaanxi , China .
FAU - Zhang, Zhong
AU  - Zhang Z
AD  - b Department of Ophthalmology , Xi'an Ninth Hospital Affiliated to Medical 
      College of Xi'an Jiaotong University , Xi'an , Shaanxi , China .
FAU - Sun, Hongzhi
AU  - Sun H
AD  - a Key Laboratory of Environment and Genes Related to Diseases , Ministry of 
      Education, School of Medicine, Xi'an Jiaotong University , Xi'an , Shaanxi , 
      China .
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150407
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Chemokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (RARRES2 protein, human)
RN  - 0 (Triglycerides)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - Chemokines/*blood
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Retinopathy/*blood
MH  - Female
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Time Factors
MH  - Triglycerides/blood
MH  - Vascular Endothelial Growth Factor A/blood
OTO - NOTNLM
OT  - Chemerin
OT  - VEGF
OT  - diabetic retinopathy
OT  - retinopathy
OT  - vascularization
EDAT- 2015/04/08 06:00
MHDA- 2016/09/27 06:00
CRDT- 2015/04/08 06:00
PHST- 2015/04/08 06:00 [entrez]
PHST- 2015/04/08 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
AID - 10.3109/02713683.2015.1004718 [doi]
PST - ppublish
SO  - Curr Eye Res. 2016;41(1):114-20. doi: 10.3109/02713683.2015.1004718. Epub 2015 
      Apr 7.