PMID- 25848901
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 276
IP  - 3
DP  - 2015 Sep
TI  - Disrupted Functional Brain Connectome in Patients with Posttraumatic Stress 
      Disorder.
PG  - 818-27
LID - 10.1148/radiol.15141700 [doi]
AB  - PURPOSE: To use resting-state functional magnetic resonance (MR) imaging and 
      graph theory approaches to systematically investigate the topological 
      organization of the functional connectome of patients with posttraumatic stress 
      disorder (PTSD). MATERIALS AND METHODS: This study was approved by the research 
      ethics committee, and all subjects provided informed consent for participation. 
      Seventy-six patients with PTSD caused by an earthquake and 76 control subjects 
      who experienced the same disaster were matched for age, sex, and years of 
      education. The study subjects underwent resting-state functional MR imaging. The 
      whole-brain functional network was then constructed by thresholding partial 
      correlation matrices of 90 brain regions. The topological organization of the 
      constructed network was analyzed by using graph theory approaches. Nonparametric 
      permutation tests were also used for group comparisons of topological metrics. 
      RESULTS: Compared with the control subjects, patients with PTSD exhibited 
      abnormalities in global properties, including a significant decrease in path 
      length (P = .0002) and increases in the clustering coefficient (P = .0014), 
      global efficiency (P = .0002), and local efficiency (P = .0004). Locally, the 
      patients with PTSD exhibited increased centrality in nodes that are predominately 
      involved in the default-mode network (DMN) and the salience network (SN), 
      including the posterior cingulate gyrus, the precuneus, the insula, the putamen, 
      the pallidum, and the temporal regions. CONCLUSION: These results suggest that 
      individuals with PTSD exhibit a shift toward "small-worldization" (in which the 
      network transforms from a random or regular network to a small-world network) 
      rather than toward randomization; furthermore, the disequilibrium between the DMN 
      and the SN might be associated with the pathophysiology of PTSD.
FAU - Lei, Du
AU  - Lei D
AD  - From Huaxi MR Research Center, the Department of Radiology, West China Hospital 
      of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China 
      (D.L., K.L., X.H., S.L., Q.G.); Mental Health Institute, the Second Xiangya 
      Hospital of Central South University, Changsha, China (L.L.); Department of 
      Medical Information Engineering, School of Electrical Engineering and 
      Information, Sichuan University, Chengdu, P.R. China (F.C); and Departments of 
      Psychiatry and Oncology, State Key Laboratory of Biotherapy, West China Hospital 
      of Sichuan University, Chengdu, China (J.L., F.B.). Supported by the National 
      Natural Science Foundation (grants 81030027, 81227002, 81220108013, 30830046, and 
      81171286), National Key Technologies Research and Development Program of China 
      (Program No. 2012BAI01B03), Program for Changjiang Scholars and Innovative 
      Research Team in University of China (grant IRT1272), and China Postdoctoral 
      Science Foundation (grants 2012M521696 and 2013T60856).
FAU - Li, Kaiming
AU  - Li K
AD  - From Huaxi MR Research Center, the Department of Radiology, West China Hospital 
      of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China 
      (D.L., K.L., X.H., S.L., Q.G.); Mental Health Institute, the Second Xiangya 
      Hospital of Central South University, Changsha, China (L.L.); Department of 
      Medical Information Engineering, School of Electrical Engineering and 
      Information, Sichuan University, Chengdu, P.R. China (F.C); and Departments of 
      Psychiatry and Oncology, State Key Laboratory of Biotherapy, West China Hospital 
      of Sichuan University, Chengdu, China (J.L., F.B.). Supported by the National 
      Natural Science Foundation (grants 81030027, 81227002, 81220108013, 30830046, and 
      81171286), National Key Technologies Research and Development Program of China 
      (Program No. 2012BAI01B03), Program for Changjiang Scholars and Innovative 
      Research Team in University of China (grant IRT1272), and China Postdoctoral 
      Science Foundation (grants 2012M521696 and 2013T60856).
FAU - Li, Lingjiang
AU  - Li L
AD  - From Huaxi MR Research Center, the Department of Radiology, West China Hospital 
      of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China 
      (D.L., K.L., X.H., S.L., Q.G.); Mental Health Institute, the Second Xiangya 
      Hospital of Central South University, Changsha, China (L.L.); Department of 
      Medical Information Engineering, School of Electrical Engineering and 
      Information, Sichuan University, Chengdu, P.R. China (F.C); and Departments of 
      Psychiatry and Oncology, State Key Laboratory of Biotherapy, West China Hospital 
      of Sichuan University, Chengdu, China (J.L., F.B.). Supported by the National 
      Natural Science Foundation (grants 81030027, 81227002, 81220108013, 30830046, and 
      81171286), National Key Technologies Research and Development Program of China 
      (Program No. 2012BAI01B03), Program for Changjiang Scholars and Innovative 
      Research Team in University of China (grant IRT1272), and China Postdoctoral 
      Science Foundation (grants 2012M521696 and 2013T60856).
FAU - Chen, Fuqin
AU  - Chen F
AD  - From Huaxi MR Research Center, the Department of Radiology, West China Hospital 
      of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China 
      (D.L., K.L., X.H., S.L., Q.G.); Mental Health Institute, the Second Xiangya 
      Hospital of Central South University, Changsha, China (L.L.); Department of 
      Medical Information Engineering, School of Electrical Engineering and 
      Information, Sichuan University, Chengdu, P.R. China (F.C); and Departments of 
      Psychiatry and Oncology, State Key Laboratory of Biotherapy, West China Hospital 
      of Sichuan University, Chengdu, China (J.L., F.B.). Supported by the National 
      Natural Science Foundation (grants 81030027, 81227002, 81220108013, 30830046, and 
      81171286), National Key Technologies Research and Development Program of China 
      (Program No. 2012BAI01B03), Program for Changjiang Scholars and Innovative 
      Research Team in University of China (grant IRT1272), and China Postdoctoral 
      Science Foundation (grants 2012M521696 and 2013T60856).
FAU - Huang, Xiaoqi
AU  - Huang X
AD  - From Huaxi MR Research Center, the Department of Radiology, West China Hospital 
      of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China 
      (D.L., K.L., X.H., S.L., Q.G.); Mental Health Institute, the Second Xiangya 
      Hospital of Central South University, Changsha, China (L.L.); Department of 
      Medical Information Engineering, School of Electrical Engineering and 
      Information, Sichuan University, Chengdu, P.R. China (F.C); and Departments of 
      Psychiatry and Oncology, State Key Laboratory of Biotherapy, West China Hospital 
      of Sichuan University, Chengdu, China (J.L., F.B.). Supported by the National 
      Natural Science Foundation (grants 81030027, 81227002, 81220108013, 30830046, and 
      81171286), National Key Technologies Research and Development Program of China 
      (Program No. 2012BAI01B03), Program for Changjiang Scholars and Innovative 
      Research Team in University of China (grant IRT1272), and China Postdoctoral 
      Science Foundation (grants 2012M521696 and 2013T60856).
FAU - Lui, Su
AU  - Lui S
AD  - From Huaxi MR Research Center, the Department of Radiology, West China Hospital 
      of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China 
      (D.L., K.L., X.H., S.L., Q.G.); Mental Health Institute, the Second Xiangya 
      Hospital of Central South University, Changsha, China (L.L.); Department of 
      Medical Information Engineering, School of Electrical Engineering and 
      Information, Sichuan University, Chengdu, P.R. China (F.C); and Departments of 
      Psychiatry and Oncology, State Key Laboratory of Biotherapy, West China Hospital 
      of Sichuan University, Chengdu, China (J.L., F.B.). Supported by the National 
      Natural Science Foundation (grants 81030027, 81227002, 81220108013, 30830046, and 
      81171286), National Key Technologies Research and Development Program of China 
      (Program No. 2012BAI01B03), Program for Changjiang Scholars and Innovative 
      Research Team in University of China (grant IRT1272), and China Postdoctoral 
      Science Foundation (grants 2012M521696 and 2013T60856).
FAU - Li, Jing
AU  - Li J
AD  - From Huaxi MR Research Center, the Department of Radiology, West China Hospital 
      of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China 
      (D.L., K.L., X.H., S.L., Q.G.); Mental Health Institute, the Second Xiangya 
      Hospital of Central South University, Changsha, China (L.L.); Department of 
      Medical Information Engineering, School of Electrical Engineering and 
      Information, Sichuan University, Chengdu, P.R. China (F.C); and Departments of 
      Psychiatry and Oncology, State Key Laboratory of Biotherapy, West China Hospital 
      of Sichuan University, Chengdu, China (J.L., F.B.). Supported by the National 
      Natural Science Foundation (grants 81030027, 81227002, 81220108013, 30830046, and 
      81171286), National Key Technologies Research and Development Program of China 
      (Program No. 2012BAI01B03), Program for Changjiang Scholars and Innovative 
      Research Team in University of China (grant IRT1272), and China Postdoctoral 
      Science Foundation (grants 2012M521696 and 2013T60856).
FAU - Bi, Feng
AU  - Bi F
AD  - From Huaxi MR Research Center, the Department of Radiology, West China Hospital 
      of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China 
      (D.L., K.L., X.H., S.L., Q.G.); Mental Health Institute, the Second Xiangya 
      Hospital of Central South University, Changsha, China (L.L.); Department of 
      Medical Information Engineering, School of Electrical Engineering and 
      Information, Sichuan University, Chengdu, P.R. China (F.C); and Departments of 
      Psychiatry and Oncology, State Key Laboratory of Biotherapy, West China Hospital 
      of Sichuan University, Chengdu, China (J.L., F.B.). Supported by the National 
      Natural Science Foundation (grants 81030027, 81227002, 81220108013, 30830046, and 
      81171286), National Key Technologies Research and Development Program of China 
      (Program No. 2012BAI01B03), Program for Changjiang Scholars and Innovative 
      Research Team in University of China (grant IRT1272), and China Postdoctoral 
      Science Foundation (grants 2012M521696 and 2013T60856).
FAU - Gong, Qiyong
AU  - Gong Q
AD  - From Huaxi MR Research Center, the Department of Radiology, West China Hospital 
      of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China 
      (D.L., K.L., X.H., S.L., Q.G.); Mental Health Institute, the Second Xiangya 
      Hospital of Central South University, Changsha, China (L.L.); Department of 
      Medical Information Engineering, School of Electrical Engineering and 
      Information, Sichuan University, Chengdu, P.R. China (F.C); and Departments of 
      Psychiatry and Oncology, State Key Laboratory of Biotherapy, West China Hospital 
      of Sichuan University, Chengdu, China (J.L., F.B.). Supported by the National 
      Natural Science Foundation (grants 81030027, 81227002, 81220108013, 30830046, and 
      81171286), National Key Technologies Research and Development Program of China 
      (Program No. 2012BAI01B03), Program for Changjiang Scholars and Innovative 
      Research Team in University of China (grant IRT1272), and China Postdoctoral 
      Science Foundation (grants 2012M521696 and 2013T60856).
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150406
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Brain/*physiopathology
MH  - *Connectome
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Stress Disorders, Post-Traumatic/*physiopathology
EDAT- 2015/04/08 06:00
MHDA- 2015/11/13 06:00
CRDT- 2015/04/08 06:00
PHST- 2015/04/08 06:00 [entrez]
PHST- 2015/04/08 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
AID - 10.1148/radiol.15141700 [doi]
PST - ppublish
SO  - Radiology. 2015 Sep;276(3):818-27. doi: 10.1148/radiol.15141700. Epub 2015 Apr 6.