PMID- 25849033 OWN - NLM STAT- MEDLINE DCOM- 20160505 LR - 20220311 IS - 1552-5279 (Electronic) IS - 1552-5260 (Print) IS - 1552-5260 (Linking) VI - 11 IP - 8 DP - 2015 Aug TI - Florbetapir PET, FDG PET, and MRI in Down syndrome individuals with and without Alzheimer's dementia. PG - 994-1004 LID - S1552-5260(15)00084-9 [pii] LID - 10.1016/j.jalz.2015.01.006 [doi] AB - INTRODUCTION: Down syndrome (DS) is associated with amyloid b (Ab) deposition. METHODS: We characterized imaging measurements of regional fibrillar Ab burden, cerebral metabolic rate for glucose (rCMRgl), gray matter volumes (rGMVs), and age associations in 5 DS with dementia (DS/AD1), 12 DS without dementia (DS/AD2), and 9 normal controls (NCs). RESULTS: There were significant group differences in mean standard uptake value ratios (SUVRs) for florbetapir with DS/AD1 having the highest, followed by DS/AD2, followed by NC. For [18F]-fluorodeoxyglucose positron emission tomography, posterior cingulate rCMRgl in DS/AD1 was significantly reduced compared with DS/AD2 and NC. For volumetric magnetic resonance imaging (vMRI), hippocampal volumes were significantly reduced for the DS/AD1 compared with DS/AD2 and NC. Age-related SUVR increases and rCMRgl reductions were greater in DS participants than in NCs. DISCUSSION: DS is associated with fibrillar Ab, rCMRgl, and rGMV alterations in the dementia stage and before the presence of clinical decline. This study provides a foundation for the studies needed to inform treatment and prevention in DS. CI - Copyright (c) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved. FAU - Sabbagh, Marwan N AU - Sabbagh MN AD - Banner Sun Health Research Institute, Sun City, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA; College of Medicine, University of Arizona, Phoenix, AZ, USA. Electronic address: marwan.sabbagh@bannerhealth.com. FAU - Chen, Kewei AU - Chen K AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; Arizona State University, Tempe, AZ, USA. FAU - Rogers, Joseph AU - Rogers J AD - SRI International, Palo Alto, CA, USA. FAU - Fleisher, Adam S AU - Fleisher AS AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA. FAU - Liebsack, Carolyn AU - Liebsack C AD - Banner Sun Health Research Institute, Sun City, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA. FAU - Bandy, Dan AU - Bandy D AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA. FAU - Belden, Christine AU - Belden C AD - Banner Sun Health Research Institute, Sun City, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA. FAU - Protas, Hillary AU - Protas H AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA. FAU - Thiyyagura, Pradeep AU - Thiyyagura P AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA. FAU - Liu, Xiaofen AU - Liu X AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA. FAU - Roontiva, Auttawut AU - Roontiva A AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA. FAU - Luo, Ji AU - Luo J AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA. FAU - Jacobson, Sandra AU - Jacobson S AD - Banner Sun Health Research Institute, Sun City, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA. FAU - Malek-Ahmadi, Michael AU - Malek-Ahmadi M AD - Banner Sun Health Research Institute, Sun City, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA. FAU - Powell, Jessica AU - Powell J AD - Banner Sun Health Research Institute, Sun City, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA. FAU - Reiman, Eric M AU - Reiman EM AD - Arizona Alzheimer's Consortium, Phoenix, AZ, USA; College of Medicine, University of Arizona, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; Translational Genomics Research Institute, Phoenix, AZ, USA. LA - eng GR - R01 MH057899/MH/NIMH NIH HHS/United States GR - R01 AG031581/AG/NIA NIH HHS/United States GR - R01AG031581/AG/NIA NIH HHS/United States GR - R01MH057899/MH/NIMH NIH HHS/United States GR - 5P30AG019610-12/AG/NIA NIH HHS/United States GR - P30 AG019610/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20150404 PL - United States TA - Alzheimers Dement JT - Alzheimer's & dementia : the journal of the Alzheimer's Association JID - 101231978 RN - 0 (Aniline Compounds) RN - 0 (Ethylene Glycols) RN - 0Z5B2CJX4D (Fluorodeoxyglucose F18) RN - 6867Q6IKOD (florbetapir) SB - IM MH - Adult MH - Alzheimer Disease/complications MH - Aniline Compounds/*metabolism MH - Brain/*diagnostic imaging/*pathology MH - Down Syndrome/complications/*pathology MH - Emergency Services, Psychiatric MH - Ethylene Glycols/*metabolism MH - Female MH - Fluorodeoxyglucose F18/*metabolism MH - Humans MH - Image Processing, Computer-Assisted MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Neuropsychological Tests MH - *Positron-Emission Tomography PMC - PMC4543530 MID - NIHMS671728 OTO - NOTNLM OT - Alzheimer's disease OT - Dementia OT - Down syndrome OT - FDG-PET OT - Florbetapir OT - Imaging OT - PET EDAT- 2015/04/08 06:00 MHDA- 2016/05/06 06:00 PMCR- 2016/08/01 CRDT- 2015/04/08 06:00 PHST- 2014/04/12 00:00 [received] PHST- 2015/01/07 00:00 [revised] PHST- 2015/01/28 00:00 [accepted] PHST- 2015/04/08 06:00 [entrez] PHST- 2015/04/08 06:00 [pubmed] PHST- 2016/05/06 06:00 [medline] PHST- 2016/08/01 00:00 [pmc-release] AID - S1552-5260(15)00084-9 [pii] AID - 10.1016/j.jalz.2015.01.006 [doi] PST - ppublish SO - Alzheimers Dement. 2015 Aug;11(8):994-1004. doi: 10.1016/j.jalz.2015.01.006. Epub 2015 Apr 4.