PMID- 25849298
OWN - NLM
STAT- MEDLINE
DCOM- 20160107
LR  - 20150408
IS  - 1752-699X (Electronic)
IS  - 1752-6981 (Linking)
VI  - 9
IP  - 2
DP  - 2015 Apr
TI  - Electromagnetic navigation-guided TBNA vs conventional TBNA in the diagnosis of 
      mediastinal lymphadenopathy.
PG  - 214-20
LID - 10.1111/crj.12126 [doi]
AB  - OBJECTIVES: Conventional transbronchial needle aspiration (C-TBNA) is a safe 
      method for the diagnosis of hilar and mediastinal lymphadenopathy (MLN). However, 
      diagnostic yield of this technique varies considerably. Electromagnetic 
      navigation bronchoscopy (ENB) is a new technology to increase the diagnostic 
      yield of flexible bronchoscopy for the peripheral lung lesions and MLN. The aim 
      of this prospective study was to compare the diagnostic and sampling success of 
      ENB-guided TBNA (ENB-TBNA) in comparison with C-TBNA while dealing with MLN. 
      METHODS: Consecutive patients with MLN were randomized into two groups - C-TBNA 
      and ENB-TBNA - using a computer-based number shuffling system to avoid 
      recruitment bias. Procedures were performed in usual fashion, published 
      previously. RESULTS: Ninety-four cases (M/F: 45/49) with a total of 145 stations 
      of MLN were enrolled in the study. In 44 patients, 81 stations were sampled by 
      ENB-TBNA, and in 50 patients 64 stations by C-TBNA. The mean size of MLN in study 
      subjects was 17.56 +/- 6.25 mm. The sampling success was significantly higher in 
      ENB-TBNA group (82.7%) compared with C-TBNA group (51.6%) (P < 0.005). Defined by 
      histopathological result, the diagnostic yield in ENB-TBNA was 72.8%, and 42.2% 
      with C-TBNA (P < 0.005). For subcarinal localization, sampling or diagnostic 
      success was higher in ENB-TBNA than that of C-TBNA (P < 0.05). Based on the size 
      of the MLN </=15 mm or >15 mm, the sampling success of ENB-TBNA was also 
      significantly higher than C-TBNA in both subgroups (P < 0.005 and P < 0.005, 
      respectively). No serious complication was observed. CONCLUSION: In this study 
      comparing ENB-TBNA and C-TBNA, the sampling and diagnostic success of ENB-TBNA 
      was found to be superior while dealing with MLN, in all categories studied.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Diken, Ozlem E
AU  - Diken OE
AD  - Department of Chest Diseases, Ankara University School of Medicine, Ankara, 
      Turkey.
FAU - Karnak, Demet
AU  - Karnak D
FAU - Ciledag, Aydin
AU  - Ciledag A
FAU - Ceyhan, Koray
AU  - Ceyhan K
FAU - Atasoy, Cetin
AU  - Atasoy C
FAU - Akyar, Serdar
AU  - Akyar S
FAU - Kayacan, Oya
AU  - Kayacan O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140320
PL  - England
TA  - Clin Respir J
JT  - The clinical respiratory journal
JID - 101315570
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bronchoscopy/*methods
MH  - *Electromagnetic Phenomena
MH  - Female
MH  - Humans
MH  - Image-Guided Biopsy/*methods
MH  - Lung Neoplasms/*pathology
MH  - Lymphatic Diseases/*pathology
MH  - Male
MH  - Mediastinal Diseases/*pathology
MH  - Middle Aged
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed
MH  - Young Adult
OTO - NOTNLM
OT  - bronchoscopy
OT  - electromagnetic navigation
OT  - electromagnetic navigation bronchoscopy
OT  - flexible bronchoscopy
OT  - mediastinal lymph node
OT  - transbronchial needle aspiration
EDAT- 2015/04/08 06:00
MHDA- 2016/01/08 06:00
CRDT- 2015/04/08 06:00
PHST- 2013/04/21 00:00 [received]
PHST- 2014/02/06 00:00 [revised]
PHST- 2014/02/17 00:00 [accepted]
PHST- 2015/04/08 06:00 [entrez]
PHST- 2015/04/08 06:00 [pubmed]
PHST- 2016/01/08 06:00 [medline]
AID - 10.1111/crj.12126 [doi]
PST - ppublish
SO  - Clin Respir J. 2015 Apr;9(2):214-20. doi: 10.1111/crj.12126. Epub 2014 Mar 20.