PMID- 25849522
OWN - NLM
STAT- MEDLINE
DCOM- 20150821
LR  - 20220331
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 160
IP  - 1
DP  - 2015 Jul
TI  - Spectrum of Retinal Vascular Diseases Associated With Paracentral Acute Middle 
      Maculopathy.
PG  - 26-34.e1
LID - S0002-9394(15)00192-0 [pii]
LID - 10.1016/j.ajo.2015.04.004 [doi]
AB  - PURPOSE: To evaluate the spectrum of retinal diseases that can demonstrate 
      paracentral acute middle maculopathy and isolated ischemia of the intermediate 
      and deep capillary plexus. DESIGN: Retrospective, multicenter, observational case 
      series. METHODS: This is a retrospective case series review of 9 patients (10 
      eyes) from 5 centers with paracentral acute middle maculopathy lesions and 
      previously unreported retinal vascular etiologies. Case presentations and 
      multimodal imaging, including color photographs, near-infrared reflectance, 
      fluorescein angiography, spectral-domain optical coherence tomography (SD OCT), 
      and orbital color Doppler imaging, are described. Baseline and follow-up findings 
      are correlated with clinical presentation, demographics, and systemic 
      associations. RESULTS: Five men and 4 women, aged 27-66 years, were included. 
      Isolated band-like hyperreflective lesions in the middle retinal layers, 
      otherwise known as paracentral acute middle maculopathy, were observed in all 
      patients at baseline presentation. Follow-up SD OCT analysis of these paracentral 
      acute middle maculopathy lesions demonstrated subsequent thinning of the inner 
      nuclear layer. Novel retinal vascular associations leading to retinal 
      vasculopathy and paracentral acute middle maculopathy include eye compression 
      injury causing global ocular ischemia, sickle cell crisis, Purtscher's 
      retinopathy, inflammatory occlusive retinal vasculitis, post-H1N1 vaccine, 
      hypertensive retinopathy, migraine disorder, and post-upper respiratory 
      infection. CONCLUSION: Paracentral acute middle maculopathy lesions may develop 
      in a wide spectrum of retinal vascular diseases. They are best identified with SD 
      OCT analysis and may represent ischemia of the intermediate and deep capillary 
      plexus. These lesions typically result in permanent thinning of the inner nuclear 
      layer and are critical to identify in order to determine the cause of unexplained 
      vision loss.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Chen, Xuejing
AU  - Chen X
AD  - Stein Eye Institute, Department of Ophthalmology, University of California Los 
      Angeles, Los Angeles, California; Greater Los Angeles Veterans Affairs Healthcare 
      Center, Los Angeles, California.
FAU - Rahimy, Ehsan
AU  - Rahimy E
AD  - Wills Eye Hospital, Philadelphia, Pennsylvania.
FAU - Sergott, Robert C
AU  - Sergott RC
AD  - Wills Eye Hospital, Philadelphia, Pennsylvania.
FAU - Nunes, Renata P
AU  - Nunes RP
AD  - Department of Ophthalmology, Universidade Federal of Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Souza, Eduardo C
AU  - Souza EC
AD  - Department of Ophthalmology, Universidade Federal of Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Choudhry, Netan
AU  - Choudhry N
AD  - Herzig Eye Institute, Toronto, Canada.
FAU - Cutler, Nathan E
AU  - Cutler NE
AD  - Wills Eye Hospital, Philadelphia, Pennsylvania.
FAU - Houston, Samuel K S
AU  - Houston SK
AD  - Wills Eye Hospital, Philadelphia, Pennsylvania.
FAU - Munk, Marion R
AU  - Munk MR
AD  - Department of Ophthalmology, Feinberg School of Medicine, Northwestern 
      University, Evanston, Illinois.
FAU - Fawzi, Amani A
AU  - Fawzi AA
AD  - Department of Ophthalmology, Feinberg School of Medicine, Northwestern 
      University, Evanston, Illinois.
FAU - Mehta, Sonia
AU  - Mehta S
AD  - Wills Eye Hospital, Philadelphia, Pennsylvania.
FAU - Hubschman, Jean-Pierre
AU  - Hubschman JP
AD  - Stein Eye Institute, Department of Ophthalmology, University of California Los 
      Angeles, Los Angeles, California.
FAU - Ho, Allen C
AU  - Ho AC
AD  - Wills Eye Hospital, Philadelphia, Pennsylvania.
FAU - Sarraf, David
AU  - Sarraf D
AD  - Stein Eye Institute, Department of Ophthalmology, University of California Los 
      Angeles, Los Angeles, California; Greater Los Angeles Veterans Affairs Healthcare 
      Center, Los Angeles, California. Electronic address: dsarraf@ucla.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150404
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
CIN - Am J Ophthalmol. 2015 Jul;160(1):1-3.e2. PMID: 26054463
MH  - Adult
MH  - Aged
MH  - Blood Pressure/physiology
MH  - Capillaries
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Ischemia/*diagnosis/etiology
MH  - Male
MH  - Middle Aged
MH  - Retinal Diseases/*diagnosis/etiology
MH  - Retinal Neurons/*pathology
MH  - Retinal Vessels/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Ultrasonography, Doppler, Color
MH  - Visual Acuity/physiology
EDAT- 2015/04/08 06:00
MHDA- 2015/08/22 06:00
CRDT- 2015/04/08 06:00
PHST- 2015/01/17 00:00 [received]
PHST- 2015/04/01 00:00 [revised]
PHST- 2015/04/02 00:00 [accepted]
PHST- 2015/04/08 06:00 [entrez]
PHST- 2015/04/08 06:00 [pubmed]
PHST- 2015/08/22 06:00 [medline]
AID - S0002-9394(15)00192-0 [pii]
AID - 10.1016/j.ajo.2015.04.004 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Jul;160(1):26-34.e1. doi: 10.1016/j.ajo.2015.04.004. Epub 
      2015 Apr 4.