PMID- 25849925
OWN - NLM
STAT- MEDLINE
DCOM- 20160101
LR  - 20240210
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 43
IP  - 2
DP  - 2015 Apr
TI  - Membrane bound O-acyltransferases and their inhibitors.
PG  - 246-52
LID - 10.1042/BST20150018 [doi]
AB  - Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein 
      family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog 
      (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown 
      to acylate specific proteins or peptides. In this review, topology determination, 
      development of assays to measure enzymatic activities and discovery of small 
      molecule inhibitors are compared and discussed for each of these enzymes.
FAU - Masumoto, Naoko
AU  - Masumoto N
AD  - *Department of Chemistry, Imperial College London, South Kensington Campus, 
      London, SW7 2AZ, U.K.
FAU - Lanyon-Hogg, Thomas
AU  - Lanyon-Hogg T
AD  - *Department of Chemistry, Imperial College London, South Kensington Campus, 
      London, SW7 2AZ, U.K.
FAU - Rodgers, Ursula R
AU  - Rodgers UR
AD  - double daggerMolecular Medicine Section, National Lung & Heart Institute, Sir Alexander 
      Fleming Building, South Kensington Campus, Imperial College London, SW7 2AZ, U.K.
FAU - Konitsiotis, Antonios D
AU  - Konitsiotis AD
AD  - double daggerMolecular Medicine Section, National Lung & Heart Institute, Sir Alexander 
      Fleming Building, South Kensington Campus, Imperial College London, SW7 2AZ, U.K.
FAU - Magee, Anthony I
AU  - Magee AI
AD  - daggerInstitute of Chemical Biology, Department of Chemistry, Imperial College London, 
      SW7 2AZ, U.K.
FAU - Tate, Edward W
AU  - Tate EW
AD  - *Department of Chemistry, Imperial College London, South Kensington Campus, 
      London, SW7 2AZ, U.K.
LA  - eng
GR  - 16402/CRUK_/Cancer Research UK/United Kingdom
GR  - G0400710/MRC_/Medical Research Council/United Kingdom
GR  - C6433/A16402/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Ghrelin)
RN  - 0 (Membrane Proteins)
RN  - 0 (Small Molecule Libraries)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (HHAT protein, human)
RN  - EC 2.3.1.- (PORCN protein, human)
SB  - IM
MH  - Acylation/genetics
MH  - Acyltransferases/antagonists & inhibitors/genetics/*metabolism
MH  - Animals
MH  - Cell Membrane/enzymology/metabolism
MH  - Ghrelin/antagonists & inhibitors/genetics/*metabolism
MH  - Humans
MH  - Lipoylation/genetics
MH  - Membrane Proteins/antagonists & inhibitors/genetics/*metabolism
MH  - Small Molecule Libraries/pharmacology
EDAT- 2015/04/08 06:00
MHDA- 2016/01/02 06:00
CRDT- 2015/04/08 06:00
PHST- 2015/04/08 06:00 [entrez]
PHST- 2015/04/08 06:00 [pubmed]
PHST- 2016/01/02 06:00 [medline]
AID - BST20150018 [pii]
AID - 10.1042/BST20150018 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2015 Apr;43(2):246-52. doi: 10.1042/BST20150018.