PMID- 25850525
OWN - NLM
STAT- MEDLINE
DCOM- 20160613
LR  - 20220410
IS  - 1432-0827 (Electronic)
IS  - 0171-967X (Linking)
VI  - 97
IP  - 4
DP  - 2015 Oct
TI  - Reduction in Endogenous Insulin Secretion is a Risk Factor of Sarcopenia in Men 
      with Type 2 Diabetes Mellitus.
PG  - 385-90
LID - 10.1007/s00223-015-9990-8 [doi]
AB  - Sarcopenia has recently attracted widespread attention, because it increases 
      risks of fall and bedridden. Although patients with type 2 diabetes mellitus 
      (T2DM) are known to have lower muscle mass of limbs than healthy people, the 
      mechanism is still unclear. We thus examined the association of muscle mass with 
      parameters of endogenous insulin secretion such as fasting immunoreactive 
      insulin, fasting C-peptide immunoreactivity (CPR), and daily urine CPR in 191 men 
      with T2DM. Muscle mass of arms and legs was evaluated by dual-energy X-ray 
      absorptiometry, and we calculated relative skeletal muscle index (RSMI), which is 
      useful for the diagnosis of sarcopenia. Multiple regression analyses adjusted for 
      age, duration of T2DM, serum creatinine, HbA1c, and insulin-like growth factor-I 
      showed that each parameter of endogenous insulin was significantly and positively 
      correlated with muscle mass of arms and legs as well as RSMI (p < 0.05). 
      Moreover, logistic regression analyses adjusted for confounding factors mentioned 
      above showed that each parameter of endogenous insulin was significantly lower in 
      subjects with sarcopenia than those without it (p < 0.05). In conclusion, 
      reduction in endogenous insulin secretion is an independent risk factor of 
      sarcopenia in men with T2DM.
FAU - Tanaka, Ken-ichiro
AU  - Tanaka K
AD  - Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, 
      693-8501, Japan. ken1nai@med.shimane-u.ac.jp.
FAU - Kanazawa, Ippei
AU  - Kanazawa I
AD  - Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, 
      693-8501, Japan. ippei.k@med.shimane-u.ac.jp.
FAU - Sugimoto, Toshitsugu
AU  - Sugimoto T
AD  - Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, 
      693-8501, Japan. sugimoto@med.shimane-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20150408
PL  - United States
TA  - Calcif Tissue Int
JT  - Calcified tissue international
JID - 7905481
RN  - 0 (Insulin)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Secretion
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sarcopenia/*complications
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - IGF-Iota
OT  - Insulin secretion
OT  - Sarcopenia
OT  - Skeletal muscle mass
EDAT- 2015/04/09 06:00
MHDA- 2016/06/14 06:00
CRDT- 2015/04/09 06:00
PHST- 2015/01/16 00:00 [received]
PHST- 2015/03/24 00:00 [accepted]
PHST- 2015/04/09 06:00 [entrez]
PHST- 2015/04/09 06:00 [pubmed]
PHST- 2016/06/14 06:00 [medline]
AID - 10.1007/s00223-015-9990-8 [pii]
AID - 10.1007/s00223-015-9990-8 [doi]
PST - ppublish
SO  - Calcif Tissue Int. 2015 Oct;97(4):385-90. doi: 10.1007/s00223-015-9990-8. Epub 
      2015 Apr 8.