PMID- 25851750
OWN - NLM
STAT- MEDLINE
DCOM- 20160209
LR  - 20150522
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Linking)
VI  - 58
IP  - 6
DP  - 2015 Jun
TI  - Serum antibody levels correlate with oral fungal cell numbers and influence the 
      patients' response to chronic paracoccidioidomycosis.
PG  - 356-61
LID - 10.1111/myc.12325 [doi]
AB  - Paracoccidioidomycosis (PCM) is a neglected fungal disease that elicits an 
      important granulomatous inflammatory reaction which aims to isolate the fungi and 
      resolve the infection; besides the innate cellular response, the patients' sera 
      may contain different levels of antibodies directed against PCM's pathogenic 
      agent: Paracoccidioides brasiliensis (Pb). The aim of the study was to assess the 
      distinct serum antibody levels of 19 chronic PCM patients and to associate these 
      levels to the granulomatous inflammatory response and presence of fungi in oral 
      lesions caused by Pb. The presence of Pb was detected and counted within oral 
      tissues using immunohistochemistry; antibody levels were classified as negative, 
      low-grade, moderate or high-grade groups. The Kruskal-Wallis and Dunn's test were 
      used to verify possible associations among the groups. Interestingly, lower 
      antibody titres were associated with lesser numbers of Pb, which favours the 
      cellular response over the humoral response to fight PCM. On the other hand, 
      negative serological results were linked to a higher presence of Pb in the 
      tissues, indicating that a deficient humoral response supports the fungal 
      proliferation. The number of Pb was conveniently associated with the level of 
      serum antibodies, showing that the humoral immune response is required, however, 
      not solely responsible to restrain the dissemination of Pb.
CI  - (c) 2015 Blackwell Verlag GmbH.
FAU - de Carli, Marina Lara
AU  - de Carli ML
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Alfenas, MG, Brazil.
FAU - Cardoso, Beatriz Cristina Bachiao
AU  - Cardoso BC
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Alfenas, MG, Brazil.
FAU - Malaquias, Luiz Cosme Cotta
AU  - Malaquias LC
AD  - Department of Immunology and Microbiology, Institute of Biomedical Sciences, 
      Federal University of Alfenas, Alfenas, MG, Brazil.
FAU - Nonogaki, Suely
AU  - Nonogaki S
AD  - Pathology Center, Adolfo Lutz Institute, Sao Paulo, SP, Brazil.
FAU - Pereira, Alessandro Antonio Costa
AU  - Pereira AA
AD  - Department of Pathology and Parasitology, Institute of Biomedical Sciences, 
      Federal University of Alfenas, Alfenas, MG, Brazil.
FAU - Sperandio, Felipe Fornias
AU  - Sperandio FF
AD  - Department of Pathology and Parasitology, Institute of Biomedical Sciences, 
      Federal University of Alfenas, Alfenas, MG, Brazil.
FAU - Hanemann, Joao Adolfo Costa
AU  - Hanemann JA
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Alfenas, MG, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150407
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
RN  - 0 (Antibodies, Fungal)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Fungal/*blood
MH  - *Colony Count, Microbial
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Mouth/*microbiology/pathology
MH  - Paracoccidioides/*isolation & purification
MH  - Paracoccidioidomycosis/drug therapy/*immunology/*microbiology
MH  - Serum/chemistry
OTO - NOTNLM
OT  - inflammation
OT  - paracoccidioides
OT  - paracoccidioidomycosis
OT  - serology
EDAT- 2015/04/09 06:00
MHDA- 2016/02/10 06:00
CRDT- 2015/04/09 06:00
PHST- 2015/01/13 00:00 [received]
PHST- 2015/03/13 00:00 [revised]
PHST- 2015/03/18 00:00 [accepted]
PHST- 2015/04/09 06:00 [entrez]
PHST- 2015/04/09 06:00 [pubmed]
PHST- 2016/02/10 06:00 [medline]
AID - 10.1111/myc.12325 [doi]
PST - ppublish
SO  - Mycoses. 2015 Jun;58(6):356-61. doi: 10.1111/myc.12325. Epub 2015 Apr 7.