PMID- 25851751 OWN - NLM STAT- MEDLINE DCOM- 20160104 LR - 20181202 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 64 DP - 2015 May TI - Vortioxetine, a multimodal antidepressant for generalized anxiety disorder: a systematic review and meta-analysis. PG - 88-98 LID - S0022-3956(15)00061-8 [pii] LID - 10.1016/j.jpsychires.2015.02.017 [doi] AB - Vortioxetine has a beneficial pharmacological profile for reducing anxiety and depression. Recently, a number of randomized, double-blind, placebo-controlled clinical trials (RCTs) of vortioxetine have been conducted in patients with generalized anxiety disorder (GAD); however, the results from GAD RCTs are inconsistent. With an extensive search of databases and clinical trial registries, four published short-term RCTs were identified and included in the present meta-analysis. The mean change in total scores on the Hamilton Anxiety Rating Scale (HAMA) from baseline was the primary endpoint. The secondary endpoints included the response and remission rates, as defined by a >/=50% reduction in HAMA total scores and a /=25 at baseline was included. Vortioxetine was significantly more effective than was placebo, with a standardized mean difference (SMD) of -0.118 (95% CIs, -0.203 to -0.033, P = 0.007). In particular, those with severe GAD (HAMA total score >/=25 at baseline) had a significantly greater benefit from vortioxetine than those without (SMD = -0.338, 95% CIs = -0.552 to -0.124, p = 0.002). The odds ratios (ORs) for vortioxetine for response and remission were 1.221 (95% CIs, 1.027 to 1.452, P = 0.024) and 1.052 (95% CIs, 0.853 to 1.296, P = 0.637), respectively. Discontinuation due to adverse events (AEs) (OR = 1.560, 1.006 to 2.419, p = 0.047) was marginally higher in vortioxetine than placebo treatment, whereas discontinuation due to any reason (OR = 0.971, 0.794 to 1.187, p = 0.771) and inefficacy (OR = 0.687, 0.380 to 1.243, p = 0.215) were not significantly different among treatment groups. Although our results suggest that vortioxetine may have a potential as an another treatment option for GAD (especially for severe GAD), they should be interpreted and translated into clinical practice with caution, as the meta-analysis was based on a limited number of RCTs. CI - Copyright (c) 2015 Elsevier Ltd. All rights reserved. FAU - Pae, Chi-Un AU - Pae CU AD - Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea; Department of Psychiatry and Behavioural Sciences, Duke University Medical Center, Durham, NC, USA. Electronic address: pae@catholic.ac.kr. FAU - Wang, Sheng-Min AU - Wang SM AD - Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea. FAU - Han, Changsu AU - Han C AD - Department of Psychiatry, Korea University, College of Medicine, Seoul, Republic of Korea. FAU - Lee, Soo-Jung AU - Lee SJ AD - Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea. FAU - Patkar, Ashwin A AU - Patkar AA AD - Department of Psychiatry and Behavioural Sciences, Duke University Medical Center, Durham, NC, USA. FAU - Masand, Praksh S AU - Masand PS AD - Global Medical Education, New York, NY, USA. FAU - Serretti, Alessandro AU - Serretti A AD - Institute of Psychiatry, Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20150311 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 RN - 0 (Anti-Anxiety Agents) RN - 0 (Piperazines) RN - 0 (Sulfides) RN - 3O2K1S3WQV (Vortioxetine) SB - IM MH - Anti-Anxiety Agents/*therapeutic use MH - Anxiety Disorders/*drug therapy MH - Humans MH - Piperazines/*therapeutic use MH - Sulfides/*therapeutic use MH - Vortioxetine OTO - NOTNLM OT - Efficacy OT - Generalized anxiety disorder OT - Meta-analysis OT - Safety OT - Tolerability OT - Vortioxetine EDAT- 2015/04/09 06:00 MHDA- 2016/01/05 06:00 CRDT- 2015/04/09 06:00 PHST- 2014/11/19 00:00 [received] PHST- 2015/02/18 00:00 [revised] PHST- 2015/02/20 00:00 [accepted] PHST- 2015/04/09 06:00 [entrez] PHST- 2015/04/09 06:00 [pubmed] PHST- 2016/01/05 06:00 [medline] AID - S0022-3956(15)00061-8 [pii] AID - 10.1016/j.jpsychires.2015.02.017 [doi] PST - ppublish SO - J Psychiatr Res. 2015 May;64:88-98. doi: 10.1016/j.jpsychires.2015.02.017. Epub 2015 Mar 11.