PMID- 25852518
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150408
LR  - 20231111
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 9
DP  - 2015
TI  - A pilot study on the effect of cognitive training on BDNF serum levels in 
      individuals with Parkinson's disease.
PG  - 130
LID - 10.3389/fnhum.2015.00130 [doi]
LID - 130
AB  - Parkinson's disease (PD) patients, besides motor dysfunctions, may also display 
      mild cognitive deficits (MCI) which increase with disease progression. The 
      neurotrophin brain-derived neurotrophic factor (BDNF) plays a role in the 
      survival of dopaminergic neurons and in the regulation of synaptic connectivity. 
      Moreover, the brain and peripheral level of this protein may be significantly 
      reduced in PD patients. These data suggest that a cognitive rehabilitation 
      protocol aimed at restoring cognitive deficits in PD patients may also involve 
      changes in this neurotrophin. Thus, in this pilot study we evaluated the effect 
      of a cognitive rehabilitation protocol focused on the training of executive 
      functioning and measured BDNF serum levels in a group of PD patients with mild 
      cognitive impairment, as compared to the effect of a placebo treatment (n = 7/8 
      group). The results showed that PD patients undergoing the cognitive 
      rehabilitation, besides improving their cognitive performance as measured with 
      the Zoo Map Test, also displayed increased serum BDNF levels as compared to the 
      placebo group. These findings suggest that BDNF serum levels may represent a 
      biomarker of the effects of cognitive rehabilitation in PD patients affected by 
      MCI. However, the functional significance of this increase in PD as well as other 
      neuropathological conditions remains to be determined.
FAU - Angelucci, Francesco
AU  - Angelucci F
AD  - Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation 
      Rome, Italy.
FAU - Peppe, Antonella
AU  - Peppe A
AD  - Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation 
      Rome, Italy.
FAU - Carlesimo, Giovanni A
AU  - Carlesimo GA
AD  - Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation 
      Rome, Italy, ; Department of Systemic Medicine, University of Rome Tor Vergata 
      Rome, Italy.
FAU - Serafini, Francesca
AU  - Serafini F
AD  - Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation 
      Rome, Italy.
FAU - Zabberoni, Silvia
AU  - Zabberoni S
AD  - Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation 
      Rome, Italy.
FAU - Barban, Francesco
AU  - Barban F
AD  - Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation 
      Rome, Italy.
FAU - Shofany, Jacob
AU  - Shofany J
AD  - Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation 
      Rome, Italy.
FAU - Caltagirone, Carlo
AU  - Caltagirone C
AD  - Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation 
      Rome, Italy, ; Department of Systemic Medicine, University of Rome Tor Vergata 
      Rome, Italy.
FAU - Costa, Alberto
AU  - Costa A
AD  - Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation 
      Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150316
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC4360779
OTO - NOTNLM
OT  - BDNF
OT  - Parkinson's disease
OT  - cognitive deficits
OT  - cognitive rehabilitation
OT  - serum levels
EDAT- 2015/04/09 06:00
MHDA- 2015/04/09 06:01
PMCR- 2015/01/01
CRDT- 2015/04/09 06:00
PHST- 2014/09/24 00:00 [received]
PHST- 2015/02/25 00:00 [accepted]
PHST- 2015/04/09 06:00 [entrez]
PHST- 2015/04/09 06:00 [pubmed]
PHST- 2015/04/09 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2015.00130 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2015 Mar 16;9:130. doi: 10.3389/fnhum.2015.00130. eCollection 
      2015.