PMID- 25853992
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20150808
IS  - 1533-4023 (Electronic)
IS  - 0160-2446 (Linking)
VI  - 66
IP  - 2
DP  - 2015 Aug
TI  - Third-hand Smoke: Impact on Hemostasis and Thrombogenesis.
PG  - 177-82
LID - 10.1097/FJC.0000000000000260 [doi]
AB  - Cigarette smoking is a major risk factor for acute coronary thrombosis. In fact, 
      both active/first-hand smoke and passive/second-hand smoke exposure are known to 
      increase the risk of coronary thrombosis. Although recently a new risk has been 
      identified and termed third-hand smoke (THS), which is the residual tobacco smoke 
      contaminant that remains after a cigarette is extinguished, it remains to be 
      determined whether it can also enhance the risk of thrombogenesis, much like 
      first-hand smoke and second-hand smoke. Therefore, the present studies 
      investigated the impact of THS exposure in the context of platelet biology and 
      related disease states. It was found that THS-exposed mice exhibited an enhanced 
      platelet aggregation and secretion responses as well as enhanced integrin 
      GPIIb-IIIa activation. Furthermore, it was found that THS exposure shortens the 
      tail bleeding time and the occlusion time in a model of thrombosis. Thus, our 
      data demonstrate for the first time (at least in mice) that THS exposure 
      increases the risk of thrombosis-based disease states, which is attributed, at 
      least in part, to their hyperactive platelets.
FAU - Karim, Zubair A
AU  - Karim ZA
AD  - *Department of Pharmaceutical Sciences, College of Pharmacy, Western University 
      of Health Sciences, Pomona, CA; and daggerDepartment of Cell Biology and Neuroscience, 
      University of California, Riverside, CA.
FAU - Alshbool, Fatima Z
AU  - Alshbool FZ
FAU - Vemana, Hari Priya
AU  - Vemana HP
FAU - Adhami, Neema
AU  - Adhami N
FAU - Dhall, Sandeep
AU  - Dhall S
FAU - Espinosa, Enma V P
AU  - Espinosa EV
FAU - Martins-Green, Manuela
AU  - Martins-Green M
FAU - Khasawneh, Fadi T
AU  - Khasawneh FT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
EIN - J Cardiovasc Pharmacol. 2015 Dec;66(6):610
MH  - Animals
MH  - Carotid Artery Thrombosis/blood/*chemically induced
MH  - Hemostasis/*drug effects/physiology
MH  - Inhalation Exposure/*adverse effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Platelet Aggregation/*drug effects/physiology
MH  - Tobacco Products/*adverse effects
MH  - Tobacco Smoke Pollution/*adverse effects
EDAT- 2015/04/09 06:00
MHDA- 2016/05/18 06:00
CRDT- 2015/04/09 06:00
PHST- 2015/04/09 06:00 [entrez]
PHST- 2015/04/09 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
AID - 10.1097/FJC.0000000000000260 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 2015 Aug;66(2):177-82. doi: 10.1097/FJC.0000000000000260.