PMID- 25854530
OWN - NLM
STAT- MEDLINE
DCOM- 20160719
LR  - 20181202
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Linking)
VI  - 22
IP  - 9
DP  - 2015
TI  - Resveratrol Partially Suppresses Inflammatory Events but Does not Affect Stroke 
      Onset in Stroke-Prone Spontaneously Hypertensive Rats.
PG  - 958-70
LID - 10.5551/jat.27789 [doi]
AB  - AIM: Resveratrol has been shown to mimic the beneficial effects of dietary 
      restriction (DR). We previously reported that DR delays stroke onset and extends 
      the lifespan in Stroke-Prone Spontaneously Hypertensive rats (SHRSP). Therefore, 
      we examined whether resveratrol mimics DR and delays stroke onset in SHRSP. 
      METHODS: Cerebrovascular endothelial cells (CVECs) from SHRSP were treated with 
      resveratrol, and the inflammatory gene expression levels and NFkappaB protein levels 
      were measured. In order to address the effects of resveratrol in vivo, SHRSP 
      (male, 10 weeks of age) were fed an experimental diet containing several doses of 
      resveratrol (0 - 0.05% (w/w)), after which we measured the plasma cytokine levels 
      and examined the stroke onset and lifespan. RESULTS: Treatment with resveratrol 
      (100 muM, 24 hours) in CVECs from SHRSP significantly decreased the interleukin 
      (IL)-1beta-induced monocyte chemoattractant protein-1 (MCP-1) mRNA expression levels 
      and p50 and p65 protein levels in the nuclear fraction. When the SHRSP were fed a 
      diet containing resveratrol for one week, the resveratrol treatment did not 
      affect the plasma lipid and glucose levels, body weight or weight of each tissue. 
      Resveratrol slightly, but not significantly, decreased the plasma levels of IL-1beta 
      and MCP-1 compared with that observed in the control group. In addition, 
      resveratrol decreased the IL-1beta and MCP-1 mRNA expression levels in the brain 
      versus the control animals. However, no doses of resveratrol delayed stroke onset 
      or extended the lifespan in SHRSP. CONCLUSIONS: In this study, resveratrol did 
      not delay stroke onset in SHRSP, although it partially suppressed systemic and 
      cerebral inflammation. These results suggest that resveratrol does not mimic the 
      beneficial effects of DR on stroke in vivo.
FAU - Chiba, Tsuyoshi
AU  - Chiba T
AD  - Information Center, National Institute of Health and Nutrition.
FAU - Yokotani, Kaori
AU  - Yokotani K
FAU - Suzuki, Sachina
AU  - Suzuki S
FAU - Itoh, Tatsuki
AU  - Itoh T
FAU - Umegaki, Keizo
AU  - Umegaki K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150407
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Stilbenes)
RN  - EC 2.7.4.3 (Adenylate Kinase)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Adenylate Kinase/metabolism
MH  - Animals
MH  - Antioxidants/therapeutic use
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Body Weight
MH  - Cerebrovascular Circulation
MH  - Chemokine CCL2/metabolism
MH  - Endothelial Cells/cytology
MH  - Inflammation/*diet therapy/*drug therapy
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Resveratrol
MH  - Signal Transduction
MH  - Stilbenes/*therapeutic use
MH  - Stroke/*drug therapy/physiopathology/*prevention & control
EDAT- 2015/04/10 06:00
MHDA- 2016/07/20 06:00
CRDT- 2015/04/10 06:00
PHST- 2015/04/10 06:00 [entrez]
PHST- 2015/04/10 06:00 [pubmed]
PHST- 2016/07/20 06:00 [medline]
AID - 10.5551/jat.27789 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2015;22(9):958-70. doi: 10.5551/jat.27789. Epub 2015 Apr 7.