PMID- 25855554
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20181202
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 22
IP  - 6
DP  - 2015 Jun
TI  - Comparison of Two Commercial Type 1 Porcine Reproductive and Respiratory Syndrome 
      Virus (PRRSV) Modified Live Vaccines against Heterologous Type 1 and Type 2 PRRSV 
      Challenge in Growing Pigs.
PG  - 631-40
LID - 10.1128/CVI.00001-15 [doi]
AB  - The objective of the present study was to compare the efficacy of two commercial 
      type 1 porcine reproductive and respiratory syndrome virus (PRRSV) modified live 
      vaccines against heterologous type 1 and type 2 PRRSV challenge in growing pigs. 
      Vaccination with a type 1 PRRSV vaccine reduced the level of viremia after type 1 
      PRRSV challenge but did not reduce the level of viremia after the type 2 PRRSV 
      challenge in pigs. Increased levels of interleukin-10 (IL-10) stimulated by type 
      2 PRRSV coincided with the low numbers of type 2 PRRSV-specific interferon 
      gamma-secreting cells (IFN-gamma-SC) in vaccinated pigs after type 2 PRRSV challenge, 
      whereas low levels of IL-10 stimulated by type 1 PRRSV coincided with high 
      numbers of type 1 PRRSV-specific IFN-gamma-SC in vaccinated pigs after type 1 PRRSV 
      challenge. Additionally, vaccination with the type 1 PRRSV vaccine effectively 
      reduced the lung lesions and type 1 PRRSV nucleic acids in type 1 
      PRRSV-challenged pigs but did not reduce lung lesions and type 2 PRRSV nucleic 
      acids in type 2 PRRSV-challenged pigs. There were no significant differences 
      between two commercial type 1 PRRSV vaccines against type 1 and type 2 PRRSV 
      challenge based on virological results, immunological responses, and pathological 
      outcomes. This study demonstrates that vaccinating pigs with the type 1 PRRSV 
      vaccine provides partial protection against respiratory disease with heterologous 
      type 1 PRRSV challenge but no protection with heterologous type 2 PRRSV 
      challenge.
CI  - Copyright (c) 2015, American Society for Microbiology. All Rights Reserved.
FAU - Kim, Taeyeon
AU  - Kim T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Park, Changhoon
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Choi, Kyuhyung
AU  - Choi K
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150408
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Vaccines, Synthetic)
RN  - 0 (Viral Vaccines)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - *Cross Protection
MH  - Interferon-gamma/metabolism
MH  - Interleukin-10/blood
MH  - Leukocytes, Mononuclear/immunology
MH  - Lung/pathology
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*immunology
MH  - Swine
MH  - Vaccines, Attenuated/administration & dosage/genetics/immunology
MH  - Vaccines, Synthetic/administration & dosage/genetics/immunology
MH  - Viral Vaccines/administration & dosage/genetics/*immunology
MH  - Viremia/prevention & control
PMC - PMC4446407
EDAT- 2015/04/10 06:00
MHDA- 2016/02/26 06:00
PMCR- 2015/12/01
CRDT- 2015/04/10 06:00
PHST- 2015/01/02 00:00 [received]
PHST- 2015/03/28 00:00 [accepted]
PHST- 2015/04/10 06:00 [entrez]
PHST- 2015/04/10 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - CVI.00001-15 [pii]
AID - 00001-15 [pii]
AID - 10.1128/CVI.00001-15 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2015 Jun;22(6):631-40. doi: 10.1128/CVI.00001-15. Epub 2015 
      Apr 8.