PMID- 25855739
OWN - NLM
STAT- MEDLINE
DCOM- 20150727
LR  - 20190108
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 89
IP  - 12
DP  - 2015 Jun
TI  - A single amino acid deletion in the matrix protein of porcine reproductive and 
      respiratory syndrome virus confers resistance to a polyclonal swine antibody with 
      broadly neutralizing activity.
PG  - 6515-20
LID - 10.1128/JVI.03287-14 [doi]
AB  - Assessment of virus neutralization (VN) activity in 176 pigs infected with 
      porcine reproductive and respiratory syndrome virus (PRRSV) identified one pig 
      with broadly neutralizing activity. A Tyr-10 deletion in the matrix protein 
      provided escape from broad neutralization without affecting homologous 
      neutralizing activity. The role of the Tyr-10 deletion was confirmed through an 
      infectious clone with a Tyr-10 deletion. The results demonstrate differences in 
      the properties and specificities of VN responses elicited during PRRSV infection.
CI  - Copyright (c) 2015, American Society for Microbiology. All Rights Reserved.
FAU - Trible, Benjamin R
AU  - Trible BR
AD  - Department of Diagnostic Medicine and Pathobiology, Kansas State University, 
      Manhattan, Kansas, USA btrible@vet.k-state.edu.
FAU - Popescu, Luca N
AU  - Popescu LN
AD  - Department of Diagnostic Medicine and Pathobiology, Kansas State University, 
      Manhattan, Kansas, USA.
FAU - Monday, Nicholas
AU  - Monday N
AD  - Department of Diagnostic Medicine and Pathobiology, Kansas State University, 
      Manhattan, Kansas, USA.
FAU - Calvert, Jay G
AU  - Calvert JG
AD  - Zoetis Inc., Global Biologics Research, Kalamazoo, Michigan, USA.
FAU - Rowland, Raymond R R
AU  - Rowland RR
AD  - Department of Diagnostic Medicine and Pathobiology, Kansas State University, 
      Manhattan, Kansas, USA.
LA  - eng
SI  - GENBANK/KM035798
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150408
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (M protein, porcine reproductive and respiratory syndrome virus)
RN  - 0 (Viral Matrix Proteins)
RN  - 42HK56048U (Tyrosine)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/*immunology
MH  - Antibodies, Viral/*immunology
MH  - Molecular Sequence Data
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Sequence Analysis, DNA
MH  - *Sequence Deletion
MH  - Swine
MH  - Tyrosine/*genetics
MH  - Viral Matrix Proteins/genetics/*immunology
PMC - PMC4474298
EDAT- 2015/04/10 06:00
MHDA- 2015/07/28 06:00
PMCR- 2015/12/15
CRDT- 2015/04/10 06:00
PHST- 2014/11/10 00:00 [received]
PHST- 2015/04/01 00:00 [accepted]
PHST- 2015/04/10 06:00 [entrez]
PHST- 2015/04/10 06:00 [pubmed]
PHST- 2015/07/28 06:00 [medline]
PHST- 2015/12/15 00:00 [pmc-release]
AID - JVI.03287-14 [pii]
AID - 03287-14 [pii]
AID - 10.1128/JVI.03287-14 [doi]
PST - ppublish
SO  - J Virol. 2015 Jun;89(12):6515-20. doi: 10.1128/JVI.03287-14. Epub 2015 Apr 8.