PMID- 25857265
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20220129
IS  - 1476-5403 (Electronic)
IS  - 1350-9047 (Print)
IS  - 1350-9047 (Linking)
VI  - 22
IP  - 11
DP  - 2015 Nov
TI  - The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold 
      protein Raidd.
PG  - 1803-11
LID - 10.1038/cdd.2015.31 [doi]
AB  - The receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a 
      death domain (RAIDD/CRADD) functions as a dual adaptor and is a constituent of 
      different multi-protein complexes implicated in the regulation of inflammation 
      and cell death. Within the PIDDosome complex, RAIDD connects the cell 
      death-related protease, Caspase-2, with the p53-induced protein with a death 
      domain 1 (PIDD1). As such, RAIDD has been implicated in DNA-damage-induced 
      apoptosis as well as in tumorigenesis. As loss of Caspase-2 leads to an 
      acceleration of tumor onset in the Emu-Myc mouse lymphoma model, whereas loss of 
      Pidd1 actually delays onset of this disease, we set out to interrogate the role 
      of Raidd in cancer in more detail. Our data obtained analyzing Emu-Myc/Raidd(-/-) 
      mice indicate that Raidd is unable to protect from c-Myc-driven lymphomagenesis. 
      Similarly, we failed to observe a modulatory effect of Raidd deficiency on 
      DNA-damage-driven cancer. The role of Caspase-2 as a tumor suppressor and that of 
      Pidd1 as a tumor promoter can therefore be uncoupled from their ability to 
      interact with the Raidd scaffold, pointing toward the existence of alternative 
      signaling modules engaging these two proteins in this context.
FAU - Peintner, L
AU  - Peintner L
AD  - Division of Developmental Immunology, Medical University of Innsbruck, 6020 
      Innsbruck, Austria.
FAU - Dorstyn, L
AU  - Dorstyn L
AD  - Centre for Cancer Biology - An Alliance between SA Pathology and the University 
      of South Australia, Adelaide, SA 5001, Australia.
FAU - Kumar, S
AU  - Kumar S
AD  - Centre for Cancer Biology - An Alliance between SA Pathology and the University 
      of South Australia, Adelaide, SA 5001, Australia.
FAU - Aneichyk, T
AU  - Aneichyk T
AD  - Division of Molecular Pathophysiology, Biocenter, Medical University of 
      Innsbruck, Innsbruck 6020, Austria.
FAU - Villunger, A
AU  - Villunger A
AD  - Division of Developmental Immunology, Medical University of Innsbruck, 6020 
      Innsbruck, Austria.
FAU - Manzl, C
AU  - Manzl C
AD  - Division of Developmental Immunology, Medical University of Innsbruck, 6020 
      Innsbruck, Austria.
AD  - Department of General Pathology, Medical University of Innsbruck, Innsbruck 6020, 
      Austria.
LA  - eng
GR  - W 1101/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150410
PL  - England
TA  - Cell Death Differ
JT  - Cell death and differentiation
JID - 9437445
RN  - 0 (CRADD Signaling Adaptor Protein)
RN  - 0 (Cradd protein, mouse)
RN  - 0 (Death Domain Receptor Signaling Adaptor Proteins)
RN  - 0 (Pidd1 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - EC 3.4.22.- (Caspase 2)
SB  - IM
MH  - Animals
MH  - CRADD Signaling Adaptor Protein/genetics/*metabolism
MH  - Caspase 2/genetics/*metabolism
MH  - Cell Cycle/drug effects/genetics
MH  - Cell Survival/genetics/radiation effects
MH  - Cells, Cultured
MH  - DNA Damage/genetics/radiation effects
MH  - Death Domain Receptor Signaling Adaptor Proteins/genetics/*metabolism
MH  - Fibrosarcoma/genetics/metabolism
MH  - Mice
MH  - Proto-Oncogene Proteins c-myc/genetics/*metabolism
PMC - PMC4648327
EDAT- 2015/04/11 06:00
MHDA- 2016/05/10 06:00
PMCR- 2015/11/01
CRDT- 2015/04/11 06:00
PHST- 2015/01/16 00:00 [received]
PHST- 2015/02/20 00:00 [revised]
PHST- 2015/03/02 00:00 [accepted]
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - cdd201531 [pii]
AID - 10.1038/cdd.2015.31 [doi]
PST - ppublish
SO  - Cell Death Differ. 2015 Nov;22(11):1803-11. doi: 10.1038/cdd.2015.31. Epub 2015 
      Apr 10.