PMID- 25858594
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20190930
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Linking)
VI  - 20
IP  - 4
DP  - 2015 Apr
TI  - Effects of titanium dioxide nanoparticles coupled with diode laser on optical 
      properties of in vitro normal and cancerous human lung tissues studied with 
      optical coherence tomography and diffuse reflectance spectra.
PG  - 046003
LID - 10.1117/1.JBO.20.4.046003 [doi]
AB  - The objective is to investigate the effects of two different sized (60 and 100 
      nm) titanium dioxide (TiO2) nanoparticles (NPs) penetration and accumulation in 
      in vitro human normal lung (NL) tissue, lung squamous cell carcinoma (LSCC) 
      tissue, and 650-nm diode laser-pretreated tissue on their optical properties 
      studied with optical coherence tomography monitoring and diffuse reflectance (DR) 
      spectra measurement. As with TiO2 NPs penetrating into the tissues, the 
      intensities of DR of the samples increase, and then the enhancements of DR and 
      the attenuation coefficients of the tissues were quantitatively calculated. The 
      results suggest that 650-nm diode laser pretreatment increased the amounts of 
      TiO2 NPs penetration and accumulation in NL and LSCC tissues, and the tissue 
      optical properties were significantly influenced by accumulation of TiO2 NPs.
FAU - Zhou, Lianpeng
AU  - Zhou L
AD  - South China Normal University, College of Biophotonics, MOE Key Laboratory of 
      Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, 
      Guangzhou, Guangdong Province 510631, China.
FAU - Wu, Guoyong
AU  - Wu G
AD  - Sun Yat-Sen University, the First Affiliated Hospital, Department of Surgery, 58 
      Zhongshan 2 Road, Guangzhou, Guangdong Province 510080, China.
FAU - Wei, Huajiang
AU  - Wei H
AD  - South China Normal University, College of Biophotonics, MOE Key Laboratory of 
      Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, 
      Guangzhou, Guangdong Province 510631, China.
FAU - Guo, Zhouyi
AU  - Guo Z
AD  - South China Normal University, College of Biophotonics, MOE Key Laboratory of 
      Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, 
      Guangzhou, Guangdong Province 510631, China.
FAU - Yang, Hongqin
AU  - Yang H
AD  - Fujian Normal University, Key Laboratory of Optoelectronic Science and Technology 
      for Medicine of Ministry of Education of China, 1 Keji Road, Fuzhou, Fujian 
      350007, China.
FAU - He, Yonghong
AU  - He Y
AD  - Tsinghua University, Graduate School at Shenzhen, 2279 Lishui Road, Shenzhen, 
      Guangdong 518055, China.
FAU - Xie, Shusen
AU  - Xie S
AD  - Fujian Normal University, Key Laboratory of Optoelectronic Science and Technology 
      for Medicine of Ministry of Education of China, 1 Keji Road, Fuzhou, Fujian 
      350007, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - South China Normal University, College of Biophotonics, MOE Key Laboratory of 
      Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, 
      Guangzhou, Guangdong Province 510631, China.
FAU - Meng, Qingan
AU  - Meng Q
AD  - Southwest Institute of Technical Physics, 7 People's South Road, Chengdu, Sichuan 
      610041, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Humans
MH  - *Lasers, Semiconductor
MH  - Lung/drug effects/*pathology/radiation effects
MH  - Lung Neoplasms/chemistry/*pathology
MH  - Metal Nanoparticles/*administration & dosage/chemistry/ultrastructure
MH  - Molecular Imaging/methods
MH  - Particle Size
MH  - Refractometry
MH  - Spectrum Analysis/methods
MH  - Titanium/chemistry/*pharmacology
MH  - Tomography, Optical Coherence/*methods
EDAT- 2015/04/11 06:00
MHDA- 2015/12/17 06:00
CRDT- 2015/04/11 06:00
PHST- 2014/12/23 00:00 [received]
PHST- 2015/03/16 00:00 [accepted]
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - 2272697 [pii]
AID - 10.1117/1.JBO.20.4.046003 [doi]
PST - ppublish
SO  - J Biomed Opt. 2015 Apr;20(4):046003. doi: 10.1117/1.JBO.20.4.046003.