PMID- 25859135
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150410
LR  - 20220408
IS  - 1319-4534 (Print)
IS  - 1319-4534 (Linking)
VI  - 29
IP  - 1
DP  - 2015 Jan-Mar
TI  - OCT: New perspectives in neuro-ophthalmology.
PG  - 9-25
LID - 10.1016/j.sjopt.2014.09.016 [doi]
AB  - Optical coherence tomography (OCT) has become essential to evaluate 
      axonal/neuronal integrity, to assess disease progression in the afferent visual 
      pathway and to predict visual recovery after surgery in compressive optic 
      neuropathies. Besides that OCT testing is considered a powerful biomarker of 
      neurodegeneration and a promising outcome measure for neuroprotective trials in 
      multiple sclerosis (MS). Currently, spectral-domain OCT (SD-OCT) technology 
      allows quantification of retinal individual layers. The Ganglion Cell layer (GCL) 
      investigation has become one of the most useful tools from a neuro-ophthalmic 
      perspective. It has a high correlation with perimetry, is predictive of future 
      progression and is a highly sensitive, specific of several neuro-ophthalmic 
      pathologies. Moreover the superior correlation with clinical measures compared to 
      peripapillary retinal nerve fiber layer (pRNFL) suggests that GCL analysis might 
      be a better approach to examine MS neurodegeneration. In disorders with optic 
      disk edema, such as ischemic optic neuropathy, papillitis and papilledema, 
      reduction in RNFL thickness caused by axonal atrophy is difficult to distinguish 
      from a swelling resolution. In this setting, and in buried optic nerve head 
      drusen (ONHD), GCL analysis may provide more accurate information than RNFL 
      analysis and it might be an early structural indicator of irreversible neuronal 
      loss. Enhanced depth imaging OCT (EDI-OCT) provides in vivo detail of ONHD, 
      allowing to evaluate and quantify the drusen dimensions. OCT is improving our 
      knowledge in hereditary optic neuropathies. Furthermore, there is growing 
      evidence about the role of OCT as an adjunctive biomarker of disorders such as 
      Alzheimer and Parkinson's disease.
FAU - Rebolleda, Gema
AU  - Rebolleda G
AD  - Hospital Universitario Ramon y Cajal. IRYCIS, Ophthalmology Service, University 
      of Alcala, Madrid, Spain.
FAU - Diez-Alvarez, Laura
AU  - Diez-Alvarez L
AD  - Hospital Universitario Ramon y Cajal. IRYCIS, Ophthalmology Service, University 
      of Alcala, Madrid, Spain.
FAU - Casado, Alfonso
AU  - Casado A
AD  - Hospital Universitario Ramon y Cajal. IRYCIS, Ophthalmology Service, University 
      of Alcala, Madrid, Spain.
FAU - Sanchez-Sanchez, Carmen
AU  - Sanchez-Sanchez C
AD  - Hospital Universitario Ramon y Cajal. IRYCIS, Ophthalmology Service, University 
      of Alcala, Madrid, Spain.
FAU - de Dompablo, Elisabet
AU  - de Dompablo E
AD  - Hospital Universitario Ramon y Cajal. IRYCIS, Ophthalmology Service, University 
      of Alcala, Madrid, Spain.
FAU - Gonzalez-Lopez, Julio J
AU  - Gonzalez-Lopez JJ
AD  - Hospital Universitario Ramon y Cajal. IRYCIS, Ophthalmology Service, University 
      of Alcala, Madrid, Spain.
FAU - Munoz-Negrete, Francisco J
AU  - Munoz-Negrete FJ
AD  - Hospital Universitario Ramon y Cajal. IRYCIS, Ophthalmology Service, University 
      of Alcala, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141005
PL  - India
TA  - Saudi J Ophthalmol
JT  - Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological 
      Society
JID - 9425601
PMC - PMC4314576
OTO - NOTNLM
OT  - Ganglion cell layer
OT  - Neuro-ophthalmology
OT  - Optical coherence tomography
EDAT- 2015/04/11 06:00
MHDA- 2015/04/11 06:01
PMCR- 2014/10/05
CRDT- 2015/04/11 06:00
PHST- 2014/07/15 00:00 [received]
PHST- 2014/09/09 00:00 [accepted]
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2015/04/11 06:01 [medline]
PHST- 2014/10/05 00:00 [pmc-release]
AID - S1319-4534(14)00114-3 [pii]
AID - 10.1016/j.sjopt.2014.09.016 [doi]
PST - ppublish
SO  - Saudi J Ophthalmol. 2015 Jan-Mar;29(1):9-25. doi: 10.1016/j.sjopt.2014.09.016. 
      Epub 2014 Oct 5.