PMID- 25859188
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150410
LR  - 20231111
IS  - 1662-5137 (Print)
IS  - 1662-5137 (Electronic)
IS  - 1662-5137 (Linking)
VI  - 9
DP  - 2015
TI  - Hippocampal subfield and medial temporal cortical persistent activity during 
      working memory reflects ongoing encoding.
PG  - 30
LID - 10.3389/fnsys.2015.00030 [doi]
LID - 30
AB  - Previous neuroimaging studies support a role for the medial temporal lobes in 
      maintaining novel stimuli over brief working memory (WM) delays, and suggest 
      delay period activity predicts subsequent memory. Additionally, slice recording 
      studies have demonstrated neuronal persistent spiking in entorhinal cortex, 
      perirhinal cortex (PrC), and hippocampus (CA1, CA3, subiculum). These data have 
      led to computational models that suggest persistent spiking in parahippocampal 
      regions could sustain neuronal representations of sensory information over many 
      seconds. This mechanism may support both WM maintenance and encoding of 
      information into long term episodic memory. The goal of the current study was to 
      use high-resolution fMRI to elucidate the contributions of the MTL cortices and 
      hippocampal subfields to WM maintenance as it relates to later episodic 
      recognition memory. We scanned participants while they performed a delayed match 
      to sample task with novel scene stimuli, and assessed their memory for these 
      scenes post-scan. We hypothesized stimulus-driven activation that persists into 
      the delay period-a putative correlate of persistent spiking-would predict later 
      recognition memory. Our results suggest sample and delay period activation in the 
      parahippocampal cortex (PHC), PrC, and subiculum (extending into DG/CA3 and CA1) 
      was linearly related to increases in subsequent memory strength. These data 
      extend previous neuroimaging studies that have constrained their analysis to 
      either the sample or delay period by modeling these together as one continuous 
      ongoing encoding process, and support computational frameworks that predict 
      persistent activity underlies both WM and episodic encoding.
FAU - Nauer, Rachel K
AU  - Nauer RK
AD  - Department of Psychological and Brain Sciences and Center for Memory and Brain, 
      Boston University, Boston, MA USA ; Brain Plasticity and Neuroimaging Laboratory, 
      Department of Anatomy and Neurobiology, Boston University School of Medicine, 
      Boston, MA USA.
FAU - Whiteman, Andrew S
AU  - Whiteman AS
AD  - Department of Psychological and Brain Sciences and Center for Memory and Brain, 
      Boston University, Boston, MA USA.
FAU - Dunne, Matthew F
AU  - Dunne MF
AD  - Brain Plasticity and Neuroimaging Laboratory, Department of Anatomy and 
      Neurobiology, Boston University School of Medicine, Boston, MA USA.
FAU - Stern, Chantal E
AU  - Stern CE
AD  - Brain Plasticity and Neuroimaging Laboratory, Department of Anatomy and 
      Neurobiology, Boston University School of Medicine, Boston, MA USA.
FAU - Schon, Karin
AU  - Schon K
AD  - Department of Psychological and Brain Sciences and Center for Memory and Brain, 
      Boston University, Boston, MA USA ; Brain Plasticity and Neuroimaging Laboratory, 
      Department of Anatomy and Neurobiology, Boston University School of Medicine, 
      Boston, MA USA.
LA  - eng
GR  - K99 AG036845/AG/NIA NIH HHS/United States
GR  - P50 MH071702/MH/NIMH NIH HHS/United States
GR  - R00 AG036845/AG/NIA NIH HHS/United States
GR  - UL1 TR000157/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20150309
PL  - Switzerland
TA  - Front Syst Neurosci
JT  - Frontiers in systems neuroscience
JID - 101477946
PMC - PMC4372545
OTO - NOTNLM
OT  - delayed matching-to-sample
OT  - high-resolution fMRI
OT  - hippocampus
OT  - medial temporal lobes
OT  - working memory
EDAT- 2015/04/11 06:00
MHDA- 2015/04/11 06:01
PMCR- 2015/01/01
CRDT- 2015/04/11 06:00
PHST- 2014/12/12 00:00 [received]
PHST- 2015/02/18 00:00 [accepted]
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2015/04/11 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnsys.2015.00030 [doi]
PST - epublish
SO  - Front Syst Neurosci. 2015 Mar 9;9:30. doi: 10.3389/fnsys.2015.00030. eCollection 
      2015.