PMID- 25859278
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150410
LR  - 20200929
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 7
DP  - 2015
TI  - Associations of betatrophin levels with irisin in Chinese women with normal 
      glucose tolerance.
PG  - 26
LID - 10.1186/s13098-015-0019-2 [doi]
LID - 26
AB  - BACKGROUND: Betatrophin may increase islet beta cell proliferation in insulin 
      resistance and irisin may improve glucose tolerance in mice. To examine the 
      relationship between betatrophin and irisin, we investigated it in middle-aged 
      Chinese subjects with normal glucose tolerance (NGT) and type 2 diabetes mellitus 
      (T2DM). METHODS: A total of 460 permanent residents of Fengxian District, aged 
      40-60 years and without T2DM, were enrolled. Anthropometric parameters, oral 
      glucose tolerance test (OGTT) results, glycosylated haemoglobin levels, blood 
      lipid levels, insulin sensitivity (homeostasis model assessment of insulin 
      resistance, HOMA-IR), beta cell function (homeostasis model assessment-beta, HOMA-beta), 
      estimated glomerular filtration rate (eGFR) and body fat composition were 
      determined. Matched for age, gender and body mass index (BMI, 18-28 kg/m2), newly 
      diagnosed T2DM (n = 50, male/female = 23/27) and NGT (n = 50, male/female = 
      21/29) subjects were selected based on the results of an OGTT. Serum betatrophin 
      and irisin levels were determined by enzyme linked immune sorbent assay (ELISA). 
      RESULTS: Males had higher levels of betatrophin compared with females in both the 
      NGT and T2DM groups. Compared with NGT subjects, the level of betatrophin in the 
      T2DM group was higher, and males in the T2DM group had higher betatrophin levels 
      than males in the NGT group, but there was no significant difference in 
      betatrophin levels in females between the T2DM and NGT groups. Spearman's 
      correlation analysis revealed that serum betatrophin levels in females with NGT 
      were positively correlated with irisin and negatively correlated with FINS 
      (fasting insulin) levels ( p < 0.05), but no correlation was found between 
      betatrophin and irisin levels in males with NGT or in males or females with T2DM. 
      In females with T2DM, circulating betatrophin levels were positively correlated 
      with weight, BMI and hip circumference (p < 0.05) but negatively correlated with 
      FPG (fasting plasma glucose) and HOMA-IR (p < 0.05). CONCLUSIONS: Gender 
      differences in the relationship between betatrophin and irisin indicate that 
      there might be cytokine-mediated crosstalk among the liver, adipose tissue and 
      skeletal muscle.
FAU - Xie, Xinmiao
AU  - Xie X
AD  - Department of Endocrinology and Metabolism, Fengxian Central Hospital, Shanghai, 
      201499 China ; The Third Clinical Medical College of Southern Medical University, 
      Guangzhou, 510515 China.
FAU - Gao, Ting
AU  - Gao T
AD  - Department of Endocrinology and Metabolism, Fengxian Central Hospital, Shanghai, 
      201499 China ; Ningyang First Hospital, Ningyang, Shandong Province 271400 China.
FAU - Yang, Meili
AU  - Yang M
AD  - Department of Endocrinology and Metabolism, Fengxian Central Hospital, Shanghai, 
      201499 China.
FAU - Chen, Peihong
AU  - Chen P
AD  - Department of Endocrinology and Metabolism, Fengxian Central Hospital, Shanghai, 
      201499 China.
FAU - Jin, Hua
AU  - Jin H
AD  - Department of Endocrinology and Metabolism, Fengxian Central Hospital, Shanghai, 
      201499 China.
FAU - Yang, Lili
AU  - Yang L
AD  - Department of Endocrinology and Metabolism, Fengxian Central Hospital, Shanghai, 
      201499 China.
FAU - Yu, Xuemei
AU  - Yu X
AD  - Department of Endocrinology and Metabolism, Fengxian Central Hospital, Shanghai, 
      201499 China.
LA  - eng
PT  - Journal Article
DEP - 20150325
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC4391688
OTO - NOTNLM
OT  - Betatrophin
OT  - Irisin
OT  - Normal glucose tolerance
OT  - Type 2 diabetes mellitus
EDAT- 2015/04/11 06:00
MHDA- 2015/04/11 06:01
PMCR- 2015/03/25
CRDT- 2015/04/11 06:00
PHST- 2014/07/29 00:00 [received]
PHST- 2015/03/05 00:00 [accepted]
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2015/04/11 06:01 [medline]
PHST- 2015/03/25 00:00 [pmc-release]
AID - 19 [pii]
AID - 10.1186/s13098-015-0019-2 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2015 Mar 25;7:26. doi: 10.1186/s13098-015-0019-2. 
      eCollection 2015.