PMID- 25859650
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20161125
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 47
IP  - 9
DP  - 2015 Sep
TI  - Differential associations of circulating asymmetric dimethylarginine and cell 
      adhesion molecules with metformin use in patients with type 2 diabetes mellitus 
      and stable coronary artery disease.
PG  - 1951-9
LID - 10.1007/s00726-015-1976-3 [doi]
AB  - Metformin, the drug of first choice in type 2 diabetes mellitus (T2DM), reduces 
      cardiovascular (CV) morbidity and mortality in part independently of improved 
      glycemic control and changes in traditional risk factors. However, there are 
      discordant reports on the effects of metformin on endothelial function in T2DM. 
      Our aim was to compare biochemical endothelial markers in patients with stable 
      coronary artery disease (CAD) and T2DM stratified by metformin use. We studied 70 
      patients (29 women, age 68 +/- 9 years) with established T2DM referred for elective 
      coronary angiography owing to stable angina who were receiving a standard CV 
      medication and metformin or other oral antidiabetic drugs. Exclusion criteria 
      included heart failure and other relevant coexistent disorders. Biochemical 
      indices of endothelial dysfunction and activation at admission were compared 
      according to metformin use for at least 1 year prior to index hospitalization. 
      Clinical characteristics were similar in patients receiving metformin (n = 40) 
      vs. those on other oral antidiabetic agents (n = 30). Plasma soluble vascular 
      cell adhesion molecule-1 (sVCAM-1) was lower (553 +/- 148 vs. 668 +/- 170 microg/L, P = 
      0.004) and asymmetric dimethylarginine (ADMA) higher (0.53 +/- 0.09 vs. 0.48 +/- 0.08 
      microM, P = 0.01) in subjects on metformin, which was maintained in multivariate 
      analysis. Symmetric dimethylarginine, intercellular adhesion molecule-1, monocyte 
      chemotactic protein-1 and E-selectin did not differ across the groups. The 
      results were substantially unchanged after exclusion of insulin users. Thus, 
      metformin use appears differentially associated with sVCAM-1 and ADMA in patients 
      with T2DM and stable CAD. Whether this observation may reflect different 
      prognostic effects of these endothelial markers in diabetes remains to be 
      studied.
FAU - Kruszelnicka, Olga
AU  - Kruszelnicka O
AD  - Department of Coronary Artery Disease and Heart Failure, John Paul II Hospital, 
      80 Pradnicka, 31-202, Cracow, Poland, olga.kruszelnicka@op.pl.
FAU - Chyrchel, Bernadeta
AU  - Chyrchel B
FAU - Golay, Alain
AU  - Golay A
FAU - Surdacki, Andrzej
AU  - Surdacki A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150410
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Cell Adhesion Molecules)
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 9100L32L2N (Metformin)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Arginine/*analogs & derivatives/blood
MH  - Cell Adhesion Molecules/*blood
MH  - *Coronary Artery Disease/blood/drug therapy
MH  - *Diabetes Mellitus, Type 2/blood/drug therapy
MH  - *Diabetic Angiopathies/blood/drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Metformin/*administration & dosage
MH  - Middle Aged
MH  - Time Factors
EDAT- 2015/04/11 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/04/11 06:00
PHST- 2015/02/03 00:00 [received]
PHST- 2015/03/30 00:00 [accepted]
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 10.1007/s00726-015-1976-3 [doi]
PST - ppublish
SO  - Amino Acids. 2015 Sep;47(9):1951-9. doi: 10.1007/s00726-015-1976-3. Epub 2015 Apr 
      10.