PMID- 25859777
OWN - NLM
STAT- MEDLINE
DCOM- 20151218
LR  - 20181207
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 20
IP  - 4
DP  - 2015 Apr 9
TI  - Evaluation of the hypoglycemic effects of flavonoids and extracts from Jatropha 
      gossypifolia L.
PG  - 6181-93
LID - 10.3390/molecules20046181 [doi]
AB  - Jatropha gossypifolia L. (Euphorbiaceae) is a plant widely used in the treatment 
      of type 2 diabetes mellitus (T2DM), but there are few scientific reports 
      validating its activity in this area. In this work and through a bioguided assay, 
      a crude extract stimulated glucose uptake in C2C12 myotubes up to 30%, thereby 
      reducing insulin resistance induced by fatty acids compared to the basal control. 
      A chromatographic fraction applied intraperitoneally (IP) in mice reduced glucose 
      by 42% in a mouse model of T2DM, after administration of 10 doses during 20 days. 
      A flavanone was purified from this active fraction and its structure was assigned 
      by 1H- and 13C-NMR (1D and 2D) and MS. This compound retains the previously 
      reported activity, stimulating in vitro the glucose uptake in a 
      concentration-dependent manner. This study indicates that Jatropha gossypifolia 
      L. extracts enhance glucose uptake in cultured myotubes and adipocytes and also 
      improving glucose tolerance in an in vivo model.
FAU - Granados, Sergio
AU  - Granados S
AD  - Grupo de Genetica Molecular y Departamento de Fisiologia y Bioquimica, Facultad 
      de Medicina, Universidad de Antioquia, Calle 67 No. 53-10, Medellin 050010, 
      Colombia. micr_clin@hotmail.com.
FAU - Balcazar, Norman
AU  - Balcazar N
AD  - Grupo de Genetica Molecular y Departamento de Fisiologia y Bioquimica, Facultad 
      de Medicina, Universidad de Antioquia, Calle 67 No. 53-10, Medellin 050010, 
      Colombia. norman.balcazar@udea.edu.co.
FAU - Guillen, Alis
AU  - Guillen A
AD  - Grupo de Genetica Molecular y Departamento de Fisiologia y Bioquimica, Facultad 
      de Medicina, Universidad de Antioquia, Calle 67 No. 53-10, Medellin 050010, 
      Colombia. alisgui@gmail.com.
FAU - Echeverri, Fernando
AU  - Echeverri F
AD  - Grupo de Quimica Organica de Productos Naturales, Instituto de Quimica, 
      Universidad de Antioquia, Calle 67 No. 53-10, Medellin 050010, Colombia. 
      feche@une.net.co.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150409
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Blood Glucose)
RN  - 0 (Flavonoids)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Diabetes Mellitus, Type 2/*drug therapy/pathology
MH  - Flavonoids/*administration & dosage/chemistry
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage/chemistry
MH  - Jatropha/chemistry
MH  - Mice
MH  - Plant Extracts/*administration & dosage/chemistry
PMC - PMC6272771
COIS- The authors declare no conflict of interest.
EDAT- 2015/04/11 06:00
MHDA- 2015/12/19 06:00
PMCR- 2015/04/09
CRDT- 2015/04/11 06:00
PHST- 2015/01/23 00:00 [received]
PHST- 2015/03/19 00:00 [revised]
PHST- 2015/03/23 00:00 [accepted]
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
PHST- 2015/04/09 00:00 [pmc-release]
AID - molecules20046181 [pii]
AID - molecules-20-06181 [pii]
AID - 10.3390/molecules20046181 [doi]
PST - epublish
SO  - Molecules. 2015 Apr 9;20(4):6181-93. doi: 10.3390/molecules20046181.