PMID- 25860232
OWN - NLM
STAT- MEDLINE
DCOM- 20160920
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 56
IP  - 12
DP  - 2015
TI  - Clinical and prognostic differences among patients with light chain deposition 
      disease, myeloma cast nephropathy and both.
PG  - 3357-64
LID - 10.3109/10428194.2015.1040011 [doi]
AB  - In some patients with light chain deposition disease (LCDD) there is also 
      evidence of myeloma cast nephropathy (MCN) on renal biopsy. The purpose of this 
      study was to evaluate the renal and survival outcome of patients with concomitant 
      diagnosis of MCN and LCDD to LCDD and MCN alone. Eighty seven patients were 
      identified and divided into LCDD (n=45), MCN (n=29), and LCDD+ MCN (n=13). 
      Patients with LCDD+ MCN had a worse overall survival (OS) compared to patients 
      with LCDD (p=0.03), but similar to patients with MCN (p=0.4). Death-censored 
      renal survival was no different amongst the groups. Presenting with acute renal 
      failure at time of renal biopsy (HR 7.2, p=0.0002) was an independent poor renal 
      prognostic factor while older age (HR 1.06, p=0.0002), presence of osteolytic 
      lesions (HR 4.4, p<0.0001), and requirement for dialysis or creatinine>/=5 mg/dL 
      (HR 3.2, p=0.0006) at time of renal biopsy were independent poor prognostic 
      factors for OS.
FAU - Zand, Ladan
AU  - Zand L
AD  - a Division of Nephrology and Hypertension , Rochester , MN , USA.
FAU - Nasr, Samih H
AU  - Nasr SH
AD  - b Department of Laboratory Medicine and Pathology , Rochester , MN , USA.
FAU - Gertz, Morie A
AU  - Gertz MA
AD  - c Division of Hematology, Mayo Clinic , Rochester , MN , USA.
FAU - Dispenzieri, Angela
AU  - Dispenzieri A
AD  - c Division of Hematology, Mayo Clinic , Rochester , MN , USA.
FAU - Lacy, Martha Q
AU  - Lacy MQ
AD  - c Division of Hematology, Mayo Clinic , Rochester , MN , USA.
FAU - Buadi, Francis K
AU  - Buadi FK
AD  - c Division of Hematology, Mayo Clinic , Rochester , MN , USA.
FAU - Kumar, Shaji
AU  - Kumar S
AD  - c Division of Hematology, Mayo Clinic , Rochester , MN , USA.
FAU - Kyle, Robert A
AU  - Kyle RA
AD  - c Division of Hematology, Mayo Clinic , Rochester , MN , USA.
FAU - Fervenza, Fernando C
AU  - Fervenza FC
AD  - a Division of Nephrology and Hypertension , Rochester , MN , USA.
FAU - Sethi, Sanjeev
AU  - Sethi S
AD  - b Department of Laboratory Medicine and Pathology , Rochester , MN , USA.
FAU - Dingli, David
AU  - Dingli D
AD  - b Department of Laboratory Medicine and Pathology , Rochester , MN , USA.
FAU - Rajkumar, S Vincent
AU  - Rajkumar SV
AD  - b Department of Laboratory Medicine and Pathology , Rochester , MN , USA.
FAU - Kapoor, Prashant
AU  - Kapoor P
AD  - c Division of Hematology, Mayo Clinic , Rochester , MN , USA.
FAU - McCurdy, Arleigh
AU  - McCurdy A
AD  - c Division of Hematology, Mayo Clinic , Rochester , MN , USA.
FAU - Leung, Nelson
AU  - Leung N
AD  - a Division of Nephrology and Hypertension , Rochester , MN , USA.
AD  - c Division of Hematology, Mayo Clinic , Rochester , MN , USA.
LA  - eng
PT  - Journal Article
DEP - 20150512
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyloid Neuropathies/*diagnosis/*etiology/mortality/therapy
MH  - Biopsy
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Kidney/metabolism/pathology/ultrastructure
MH  - Kidney Diseases/*diagnosis/*etiology/mortality/therapy
MH  - Kidney Tubules, Distal/metabolism/pathology/ultrastructure
MH  - Male
MH  - Microscopy, Fluorescence
MH  - Middle Aged
MH  - Multiple Myeloma/*complications
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Light chain deposition disease
OT  - multiple myeloma
OT  - myeloma cast nephropathy
OT  - renal disease
EDAT- 2015/04/11 06:00
MHDA- 2016/09/22 06:00
CRDT- 2015/04/11 06:00
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2016/09/22 06:00 [medline]
AID - 10.3109/10428194.2015.1040011 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2015;56(12):3357-64. doi: 10.3109/10428194.2015.1040011. Epub 2015 
      May 12.