PMID- 25860659
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20181113
IS  - 1531-135X (Electronic)
IS  - 1530-7026 (Linking)
VI  - 15
IP  - 3
DP  - 2015 Sep
TI  - Orbitofrontal or accumbens dopamine depletion does not affect risk-based decision 
      making in rats.
PG  - 507-22
LID - 10.3758/s13415-015-0353-8 [doi]
AB  - Considerable evidence has implicated dopamine (DA) signals in target regions of 
      midbrain DA neurons such as the medial prefrontal cortex or the core region of 
      the nucleus accumbens in controlling risk-based decision-making. However, to date 
      little is known about the contribution of DA in the orbitofrontal cortex (OFC) 
      and the medial shell region of the nucleus accumbens (AcbS) to risk-based 
      decision-making. Here we examined in rats the effects of 
      6-hydroxydopamine-induced DA depletions of the OFC and AcbS on risky choice using 
      an instrumental two-lever choice task that requires the assessment of fixed 
      within-session reward probabilities that were shifted across subsequent sessions, 
      i.e., rats had to choose between two levers, a small/certain lever that delivered 
      one certain food reward (one pellet at p = 1) and a large/risky lever that 
      delivered a larger uncertain food reward with decreasing probabilities across 
      subsequent sessions (four pellets at p = 0.75, 0.5, 0.25, 0.125, 0.0625). Results 
      show that systemic administration of amphetamine or cocaine increased the 
      preference for the large/risky lever. Results further demonstrate that, like sham 
      controls, rats with OFC or AcbS DA depletion were sensitive to changes in 
      probabilities for obtaining the large/risky reward across sessions and displayed 
      probabilistic discounting. These findings point to the view that the basal 
      capacity to evaluate the magnitude and likelihood of rewards associated with 
      alternative courses of action as well as long-term changes of reward 
      probabilities does not rely on DA input to the AcbS or OFC.
FAU - Mai, Bettina
AU  - Mai B
AD  - Department of Animal Physiology, University of Stuttgart, Pfaffenwaldring 57, 
      70550, Stuttgart, Germany.
FAU - Hauber, Wolfgang
AU  - Hauber W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cogn Affect Behav Neurosci
JT  - Cognitive, affective & behavioral neuroscience
JID - 101083946
RN  - 0 (Dopamine Agents)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - CK833KGX7E (Amphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Cocaine/pharmacology
MH  - Decision Making/drug effects/*physiology
MH  - Dopamine/*deficiency
MH  - Dopamine Agents/pharmacology
MH  - Frontal Lobe/drug effects/*metabolism
MH  - Male
MH  - Neuropsychological Tests
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Oxidopamine/pharmacology
MH  - Probability
MH  - Rats
MH  - Reward
MH  - *Risk-Taking
EDAT- 2015/04/11 06:00
MHDA- 2016/05/10 06:00
CRDT- 2015/04/11 06:00
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
AID - 10.3758/s13415-015-0353-8 [doi]
PST - ppublish
SO  - Cogn Affect Behav Neurosci. 2015 Sep;15(3):507-22. doi: 
      10.3758/s13415-015-0353-8.