PMID- 25860853
OWN - NLM
STAT- MEDLINE
DCOM- 20170505
LR  - 20181113
IS  - 1613-7671 (Electronic)
IS  - 0043-5325 (Linking)
VI  - 128
IP  - 21-22
DP  - 2016 Nov
TI  - Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in 
      common variable immunodeficiency.
PG  - 822-826
AB  - BACKGROUND: We aimed herein to investigate the killer-cell immunoglobulin-like 
      receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles in patients with 
      common variable immunodeficiency (CVID), and to reveal their differences from 
      those in healthy population. METHODS: In all, 18 patients who have been diagnosed 
      with CVID and 15 living donors of kidney transplant recipients were enrolled in 
      the study. Polymerase chain reaction-sequence-specific primer (PCR-SSP) typing 
      method was used in molecular genetic analysis. The frequencies of the genes in 
      the study groups were statistically compared with each other using chi-square or 
      Fisher exact tests, whichever were appropriate. RESULTS: Although there was no 
      significant difference between both study groups with respect to distribution of 
      KIR and HLA-C2 group genes, HLA-Cw7 allele frequency in patients with CVID was 
      significantly lower than that in healthy population (P = 0.008). CONCLUSION: This 
      present study results support that HLA-Cw7 allele, an inhibitor of KIR ligand, 
      may play a role in the pathogenesis of CVID.
FAU - Kartal, Ozgur
AU  - Kartal O
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey. okartal@gata.edu.tr.
FAU - Musabak, Ugur
AU  - Musabak U
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey.
FAU - Yesillik, Sait
AU  - Yesillik S
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey.
FAU - Sagkan, Rahsan I
AU  - Sagkan RI
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey.
FAU - Pekel, Aysel
AU  - Pekel A
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey.
FAU - Demirel, Fevzi
AU  - Demirel F
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey.
FAU - Baysan, Abdullah
AU  - Baysan A
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey.
FAU - Selcuk, Ali
AU  - Selcuk A
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey.
FAU - Gulec, Mustafa
AU  - Gulec M
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey.
FAU - Sener, Osman
AU  - Sener O
AD  - Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy 
      and School of Medicine, 06018, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20150410
PL  - Austria
TA  - Wien Klin Wochenschr
JT  - Wiener klinische Wochenschrift
JID - 21620870R
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
EIN - Wien Klin Wochenschr. 2016 Apr;128(7-8):305. PMID: 26567003
MH  - Adult
MH  - Common Variable Immunodeficiency/epidemiology/*genetics/*immunology
MH  - Female
MH  - Genetic Association Studies/methods
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - HLA-C Antigens/*genetics/*immunology
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Prevalence
MH  - Receptors, KIR/*genetics/*immunology
MH  - Risk Factors
MH  - Turkey/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Common variable immunodeficiency
OT  - Human leukocyte antigen-C alleles
OT  - Killer-cell immunoglobulin-like receptor
EDAT- 2015/04/11 06:00
MHDA- 2017/05/06 06:00
CRDT- 2015/04/11 06:00
PHST- 2014/07/25 00:00 [received]
PHST- 2015/02/16 00:00 [accepted]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2017/05/06 06:00 [medline]
PHST- 2015/04/11 06:00 [entrez]
AID - 10.1007/s00508-015-0769-8 [pii]
AID - 10.1007/s00508-015-0769-8 [doi]
PST - ppublish
SO  - Wien Klin Wochenschr. 2016 Nov;128(21-22):822-826. doi: 
      10.1007/s00508-015-0769-8. Epub 2015 Apr 10.