PMID- 25861456
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150411
LR  - 20221109
IS  - 2053-8790 (Print)
IS  - 2053-8790 (Electronic)
IS  - 2053-8790 (Linking)
VI  - 2
IP  - 1
DP  - 2015
TI  - Brain metabolism and autoantibody titres predict functional impairment in 
      systemic lupus erythematosus.
PG  - e000074
LID - 10.1136/lupus-2014-000074 [doi]
LID - e000074
AB  - OBJECTIVE: We investigated whether systemic lupus erythematosus (SLE) disease 
      duration or serology associate with abnormal regional glucose metabolism as 
      measured with [(18)F]2-fluoro-2-deoxy-D-glucose positron emission tomography 
      (FDG-PET) and deficits on neuropsychological testing. METHODS: Subjects with SLE 
      with stable disease activity, without brain damage or clinical symptoms of 
      neuropsychiatric (NP) SLE, stratified by disease duration (short-term 
      (ST)-SLE=disease </=2 years, long-term (LT)-SLE=disease >/=10 years), underwent 
      clinical assessments, neuropsychological testing, resting FDG-PET scan imaging 
      and measurement of serum titres of antibody to N-methyl-d-aspartate receptor 
      (DNRAb). FDG-PET scans were compared with age-matched and gender-matched healthy 
      controls. RESULTS: Subjects with LT-SLE demonstrated hypometabolism in the 
      prefrontal and premotor cortices that correlated with accrued SLE-related damage, 
      but not with DNRAb titre or performance on NP testing. Independent of disease 
      duration, subjects with SLE demonstrated hypermetabolism in the hippocampus and 
      orbitofrontal cortex that correlated with impaired memory performance and mood 
      alterations (depression, anxiety, fatigue). Serum DNRAb also correlated 
      independently with impaired memory performance and increased anxiety. Together, 
      serum DNRAb titre and regional hypermetabolism were more powerful predictors of 
      performance than either alone. INTERPRETATION: The presence of serum DNRAbs can 
      account for some aspects of brain dysfunction in patients with SLE, and the 
      addition of regional measurements of resting brain metabolism improves the 
      assessment and precise attribution of central nervous system manifestations 
      related to SLE.
FAU - Mackay, Meggan
AU  - Mackay M
AD  - Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for 
      Medical Research , Manhasset, New York , USA.
FAU - Tang, Chris C
AU  - Tang CC
AD  - Center for Neurosciences, The Feinstein Institute for Medical Research , 
      Manhasset, New York , USA.
FAU - Volpe, Bruce T
AU  - Volpe BT
AD  - Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for 
      Medical Research , Manhasset, New York , USA.
FAU - Aranow, Cynthia
AU  - Aranow C
AD  - Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for 
      Medical Research , Manhasset, New York , USA.
FAU - Mattis, Paul J
AU  - Mattis PJ
AD  - Center for Neurosciences, The Feinstein Institute for Medical Research , 
      Manhasset, New York , USA.
FAU - Korff, Ricki A
AU  - Korff RA
AD  - Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for 
      Medical Research , Manhasset, New York , USA.
FAU - Diamond, Betty
AU  - Diamond B
AD  - Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for 
      Medical Research , Manhasset, New York , USA.
FAU - Eidelberg, David
AU  - Eidelberg D
AD  - Center for Neurosciences, The Feinstein Institute for Medical Research , 
      Manhasset, New York , USA.
LA  - eng
GR  - P01 AI073693/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20150328
PL  - England
TA  - Lupus Sci Med
JT  - Lupus science & medicine
JID - 101633705
PMC - PMC4379887
OTO - NOTNLM
OT  - Autoantibodies
OT  - Autoimmune Diseases
OT  - Systemic Lupus Erythematosus
EDAT- 2015/04/11 06:00
MHDA- 2015/04/11 06:01
PMCR- 2015/03/28
CRDT- 2015/04/11 06:00
PHST- 2014/11/12 00:00 [received]
PHST- 2015/02/11 00:00 [revised]
PHST- 2015/03/02 00:00 [accepted]
PHST- 2015/04/11 06:00 [entrez]
PHST- 2015/04/11 06:00 [pubmed]
PHST- 2015/04/11 06:01 [medline]
PHST- 2015/03/28 00:00 [pmc-release]
AID - lupus-2014-000074 [pii]
AID - 10.1136/lupus-2014-000074 [doi]
PST - epublish
SO  - Lupus Sci Med. 2015 Mar 28;2(1):e000074. doi: 10.1136/lupus-2014-000074. 
      eCollection 2015.