PMID- 25861975
OWN - NLM
STAT- MEDLINE
DCOM- 20151230
LR  - 20220409
IS  - 1545-3278 (Electronic)
IS  - 0732-0582 (Linking)
VI  - 33
DP  - 2015
TI  - HLA-B27.
PG  - 29-48
LID - 10.1146/annurev-immunol-032414-112110 [doi]
AB  - Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly 
      associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 
      is unknown. Two broad theories most likely explain the role of HLA-B27 in AS 
      pathogenesis. The first is based on the natural immunological function of HLA-B27 
      of presenting antigenic peptides to cytotoxic T cells. Thus, HLA-B27-restricted 
      immune responses to self-antigens, or arthritogenic peptides, might drive 
      immunopathology. B27 can also "behave badly," misfolding during assembly and 
      leading to endoplasmic reticulum stress and autophagy responses. beta2m-free B27 
      heavy chain structures including homodimers (B272) can also be expressed at the 
      cell surface following endosomal recycling of cell surface heterotrimers. Cell 
      surface free heavy chains and B272 bind to innate immune receptors on T, NK, and 
      myeloid cells with proinflammatory effects. This review describes the natural 
      function of HLA-B27, its disease associations, and the current theories as to its 
      pathogenic role.
FAU - Bowness, Paul
AU  - Bowness P
AD  - Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science 
      (NDORMS), Botnar Research Center, University of Oxford, Headington, Oxford OX3 
      9DL, United Kingdom; email: Paul.bowness@ndorms.ox.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Animals
MH  - HLA-B27 Antigen/chemistry/genetics/*immunology/*metabolism
MH  - Humans
MH  - Spondylarthropathies/etiology
OTO - NOTNLM
OT  - ankylosing spondylitis
OT  - antigen presentation
OT  - arthritogenic peptide
OT  - homodimer
OT  - spondyloarthritis
EDAT- 2015/04/12 06:00
MHDA- 2015/12/31 06:00
CRDT- 2015/04/12 06:00
PHST- 2015/04/12 06:00 [entrez]
PHST- 2015/04/12 06:00 [pubmed]
PHST- 2015/12/31 06:00 [medline]
AID - 10.1146/annurev-immunol-032414-112110 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 2015;33:29-48. doi: 10.1146/annurev-immunol-032414-112110.