PMID- 25862118
OWN - NLM
STAT- MEDLINE
DCOM- 20160425
LR  - 20160602
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 16
IP  - 5
DP  - 2015 May
TI  - Impact of obesity on cognitive outcome in children with sleep-disordered 
      breathing.
PG  - 625-30
LID - S1389-9457(15)00087-8 [pii]
LID - 10.1016/j.sleep.2014.12.015 [doi]
AB  - OBJECTIVES: The objective of this study was to evaluate the impact of obesity on 
      cognitive impairment, in children with obstructive sleep apnoea (OSA), children 
      with OSA and obesity, and in normal controls. METHODS: Thirty-six children with 
      OSA (group 1), 38 children with OSA and obesity (group 2) and 58 normal controls 
      (group 3) were studied. The Total intelligence quotient (T-IQ), Verbal IQ (V-IQ) 
      and the Performance IQ (P-IQ) scores were obtained using the Wechsler 
      Intelligence Scale for Children - Third Edition Revised. All participants' 
      parents filled out the questionnaire containing the attention deficit and 
      hyperactive disorder rating scale to investigate symptoms of hyperactivity and 
      attention deficit. Obese and non-obese children with sleep-disordered breathing 
      (SDB) underwent polysomnography. RESULTS: T-QI and P-QI scores were significantly 
      lower in group 2 with higher performance impairment at the subtest compared to 
      other groups. In obese children, V-IQ was significantly correlated with age of 
      onset (r = 0.335, p = 0.05) and duration of SDB (r = -0.362, p = 0.02), while 
      P-IQ and T-IQ were correlated with body mass index (BMI) percentile (r = -0.341, 
      p = 0.03) and respiratory disturbance index (RDI) (r = -0.321, p = 0.05), 
      respectively. RDI and BMI negatively influenced T-IQ in obese children with OSA. 
      No correlation was found between sleep parameters and IQ scores or subtest scores 
      in all groups. CONCLUSIONS: Obese children with OSA showed higher cognitive 
      impairment. Obesity has an additive and synergic action with that exerted by OSA, 
      speeding up the onset of complications.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Vitelli, Ottavio
AU  - Vitelli O
AD  - Neuroscience, Mental Health and Sense Organs Department, Paediatric Sleep 
      Disorder Centre, Faculty of Medicine and Psychology, La Sapienza' University, 
      Rome.
FAU - Tabarrini, Alessandra
AU  - Tabarrini A
AD  - Neuroscience, Mental Health and Sense Organs Department, Paediatric Sleep 
      Disorder Centre, Faculty of Medicine and Psychology, La Sapienza' University, 
      Rome.
FAU - Miano, Silvia
AU  - Miano S
AD  - Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital of 
      Lugano, Switzerland.
FAU - Rabasco, Jole
AU  - Rabasco J
AD  - Neuroscience, Mental Health and Sense Organs Department, Paediatric Sleep 
      Disorder Centre, Faculty of Medicine and Psychology, La Sapienza' University, 
      Rome.
FAU - Pietropaoli, Nicoletta
AU  - Pietropaoli N
AD  - Neuroscience, Mental Health and Sense Organs Department, Paediatric Sleep 
      Disorder Centre, Faculty of Medicine and Psychology, La Sapienza' University, 
      Rome.
FAU - Forlani, Martina
AU  - Forlani M
AD  - Neuroscience, Mental Health and Sense Organs Department, Paediatric Sleep 
      Disorder Centre, Faculty of Medicine and Psychology, La Sapienza' University, 
      Rome.
FAU - Parisi, Pasquale
AU  - Parisi P
AD  - Neuroscience, Mental Health and Sense Organs Department, Paediatric Sleep 
      Disorder Centre, Faculty of Medicine and Psychology, La Sapienza' University, 
      Rome.
FAU - Villa, Maria Pia
AU  - Villa MP
AD  - Neuroscience, Mental Health and Sense Organs Department, Paediatric Sleep 
      Disorder Centre, Faculty of Medicine and Psychology, La Sapienza' University, 
      Rome. Electronic address: mariapia.villa@uniroma1.it.
LA  - eng
PT  - Journal Article
DEP - 20150207
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
SB  - IM
CIN - Sleep Med. 2016 Jan;17:164. PMID: 26212229
CIN - Sleep Med. 2016 Jan;17:163. PMID: 26212232
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Child
MH  - Cognition Disorders/etiology
MH  - Female
MH  - Humans
MH  - *Intelligence
MH  - Intelligence Tests
MH  - Male
MH  - Obesity/*complications
MH  - Polysomnography
MH  - Sleep Apnea Syndromes/*complications
MH  - Wechsler Scales
OTO - NOTNLM
OT  - Children
OT  - Cognitive impairment
OT  - Obesity
OT  - Sleep-disordered breathing
EDAT- 2015/04/12 06:00
MHDA- 2016/04/26 06:00
CRDT- 2015/04/12 06:00
PHST- 2014/09/02 00:00 [received]
PHST- 2014/12/15 00:00 [revised]
PHST- 2014/12/15 00:00 [accepted]
PHST- 2015/04/12 06:00 [entrez]
PHST- 2015/04/12 06:00 [pubmed]
PHST- 2016/04/26 06:00 [medline]
AID - S1389-9457(15)00087-8 [pii]
AID - 10.1016/j.sleep.2014.12.015 [doi]
PST - ppublish
SO  - Sleep Med. 2015 May;16(5):625-30. doi: 10.1016/j.sleep.2014.12.015. Epub 2015 Feb 
      7.