PMID- 25862890
OWN - NLM
STAT- MEDLINE
DCOM- 20150930
LR  - 20231213
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 35
IP  - 4
DP  - 2015 Apr
TI  - Human leukocyte antigen (HLA)-E and HLA-F expression in gastric cancer.
PG  - 2279-85
AB  - Human leukocyte antigen (HLA)-E and HLA-F are classified as non-classical HLA 
      class Ib antigens. Ectopic HLA-E and HLA-F expression was recently detected in 
      cancer cells; however, the clinical implication of their expression remains 
      unknown. A total of 209 patients with gastric cancer were enrolled in this study. 
      Immunohistochemistry was used to evaluate the expression of HLA-E and HLA-F in 
      gastric cancer specimens. HLA-E and HLA-F expression were seen in the cell 
      membrane. HLA-E and HLA-F expression significantly correlated with depth of 
      invasion, nodal involvement, lymphatic invasion, and venous invasion. No 
      significant correlation between HLA-E and HLA-F expression was found (p<0.05, 
      r=0.24). The five-year survival rate of the HLA-E-positive group and 
      HLA-F-positive group were significantly poorer than that of their respective 
      negative groups. Combination of HLA-E and HLA-F made the p-value smaller than 
      single analysis (p<0.009). This is the first report detailing a clinical 
      implication of HLA-E and HLA-F expression simultaneously in gastric cancer. We 
      identified that the HLA-E and HLA-F in gastric cancer independently affected 
      clinical factors, including postoperative outcome. For HLA-E- or HLA-F-positive 
      gastric cancer, we should settle on a treatment strategy that reinforces the host 
      immune response.
CI  - Copyright(c) 2015 International Institute of Anticancer Research (Dr. John G. 
      Delinassios), All rights reserved.
FAU - Ishigami, Sumiya
AU  - Ishigami S
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan 
      ishiga@m.kufm.kagoshima-u.ac.jp.
FAU - Arigami, Takaaki
AU  - Arigami T
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Okumura, Hiroshi
AU  - Okumura H
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Uchikado, Yasuto
AU  - Uchikado Y
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Kita, Yoshiaki
AU  - Kita Y
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Kurahara, Hiroshi
AU  - Kurahara H
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Maemura, Kosei
AU  - Maemura K
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Kijima, Yuko
AU  - Kijima Y
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Ishihara, Yuka
AU  - Ishihara Y
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Sasaki, Ken
AU  - Sasaki K
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Uenosono, Yoshikazu
AU  - Uenosono Y
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
FAU - Natsugoe, Shoji
AU  - Natsugoe S
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (HLA-F antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Histocompatibility Antigens Class I/*biosynthesis/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Prognosis
MH  - Stomach Neoplasms/*genetics/immunology/pathology/surgery
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - HLA-E Antigens
OTO - NOTNLM
OT  - Gastric cancer
OT  - HLA-E
OT  - HLA-F
OT  - immuno suppression
OT  - postoperative outcome
EDAT- 2015/04/12 06:00
MHDA- 2015/10/01 06:00
CRDT- 2015/04/12 06:00
PHST- 2015/04/12 06:00 [entrez]
PHST- 2015/04/12 06:00 [pubmed]
PHST- 2015/10/01 06:00 [medline]
AID - 35/4/2279 [pii]
PST - ppublish
SO  - Anticancer Res. 2015 Apr;35(4):2279-85.