PMID- 25863138
OWN - NLM
STAT- MEDLINE
DCOM- 20160307
LR  - 20220410
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Linking)
VI  - 33
IP  - 6
DP  - 2015 Jul
TI  - Native T1-mapping for non-contrast assessment of myocardial fibrosis in patients 
      with hypertrophic cardiomyopathy--comparison with late enhancement 
      quantification.
PG  - 718-24
LID - S0730-725X(15)00099-5 [pii]
LID - 10.1016/j.mri.2015.04.001 [doi]
AB  - BACKGROUND: Myocardial fibrosis was shown to influence prognosis in hypertrophic 
      cardiomyopathy (HCM). It is typically assessed by late gadolinium enhancement 
      (LGE) on cardiac magnetic resonance. Native T1-mapping has been proposed, as a 
      contrast-free method of fibrosis assessment. The aim of the study was to define a 
      cut-off value for native T1 relaxation time that best reflects LGE quantification 
      of myocardial fibrosis. METHODS: In 25 patients with HCM and 20 controls we 
      performed T1-mapping pre-contrast using ShMOLLI technique. This was followed by 
      LGE assessment in the studied group 10 minutes after gadolinium contrast 
      injection. Relative myocardial fibrosis size was calculated for varying T1 time 
      thresholds (940-1100 ms) and compared with 6 standard deviations (6SD) method for 
      LGE. RESULTS: Median fibrosis size calculated with T1-mapping was insignificantly 
      different from LGE only for native T1 time threshold of 1060 ms (p = 0.62). Using 
      this threshold, Bland-Altman plots demonstrated very good agreement between 
      fibrosis sizes from the two methods (slightly better only for 1080 ms threshold). 
      For threshold of 1060 ms we also observed good correlation (rho = 0.73) with LGE 
      6SD method (insignificantly better for lower thresholds, best for threshold of 
      980 ms-rho = 0.88). In control group with no diagnosis of HCM, fibrosis size <1% 
      was reached for thresholds of 1040 ms and higher. CONCLUSION: Native T1-mapping 
      can be used for non-contrast assessment of myocardial fibrosis in HCM. The 1060 
      ms threshold of the native T1 relaxation time is characterized by the best 
      balance between agreement and correlation with fibrosis assessed by LGE 6SD 
      method.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Malek, Lukasz A
AU  - Malek LA
AD  - Department of Interventional Cardiology and Angiology, Institute of Cardiology, 
      Warsaw, Poland; Magnetic Resonance Unit, Department of Radiology, Institute of 
      Cardiology, Warsaw, Poland. Electronic address: lmalek@ikard.pl.
FAU - Werys, Konrad
AU  - Werys K
AD  - Magnetic Resonance Unit, Department of Radiology, Institute of Cardiology, 
      Warsaw, Poland; Institute of Radioelectronics, Warsaw University of Technology, 
      Warsaw, Poland.
FAU - Klopotowski, Mariusz
AU  - Klopotowski M
AD  - Department of Interventional Cardiology and Angiology, Institute of Cardiology, 
      Warsaw, Poland.
FAU - Spiewak, Mateusz
AU  - Spiewak M
AD  - Magnetic Resonance Unit, Department of Radiology, Institute of Cardiology, 
      Warsaw, Poland; Department of Coronary Artery Disease and Structural Heart 
      Diseases, Institute of Cardiology, Warsaw, Poland.
FAU - Milosz-Wieczorek, Barbara
AU  - Milosz-Wieczorek B
AD  - Magnetic Resonance Unit, Department of Radiology, Institute of Cardiology, 
      Warsaw, Poland.
FAU - Mazurkiewicz, Lukasz
AU  - Mazurkiewicz L
AD  - Department of Cardiomyopathies, Institute of Cardiology, Warsaw, Poland.
FAU - Petryka-Mazurkiewicz, Joanna
AU  - Petryka-Mazurkiewicz J
AD  - Department of Coronary Artery Disease and Structural Heart Diseases, Institute of 
      Cardiology, Warsaw, Poland.
FAU - Marczak, Magdalena
AU  - Marczak M
AD  - Magnetic Resonance Unit, Department of Radiology, Institute of Cardiology, 
      Warsaw, Poland.
FAU - Witkowski, Adam
AU  - Witkowski A
AD  - Department of Interventional Cardiology and Angiology, Institute of Cardiology, 
      Warsaw, Poland.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150408
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Hypertrophic/*pathology
MH  - Contrast Media
MH  - Female
MH  - Fibrosis
MH  - *Gadolinium
MH  - Humans
MH  - *Image Enhancement
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
OTO - NOTNLM
OT  - Fibrosis
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - Magnetic resonance
OT  - Native T1-mapping
OT  - ShMOLLI
EDAT- 2015/04/12 06:00
MHDA- 2016/03/08 06:00
CRDT- 2015/04/12 06:00
PHST- 2015/01/01 00:00 [received]
PHST- 2015/03/10 00:00 [revised]
PHST- 2015/04/06 00:00 [accepted]
PHST- 2015/04/12 06:00 [entrez]
PHST- 2015/04/12 06:00 [pubmed]
PHST- 2016/03/08 06:00 [medline]
AID - S0730-725X(15)00099-5 [pii]
AID - 10.1016/j.mri.2015.04.001 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2015 Jul;33(6):718-24. doi: 10.1016/j.mri.2015.04.001. Epub 
      2015 Apr 8.