PMID- 25863428
OWN - NLM
STAT- MEDLINE
DCOM- 20160426
LR  - 20161125
IS  - 1875-2128 (Electronic)
IS  - 1875-2128 (Linking)
VI  - 108
IP  - 6-7
DP  - 2015 Jun-Jul
TI  - Mitral annular plane systolic excursion is an easy tool for fibrosis detection by 
      late gadolinium enhancement cardiovascular magnetic resonance imaging in patients 
      with hypertrophic cardiomyopathy.
PG  - 356-66
LID - S1875-2136(15)00047-9 [pii]
LID - 10.1016/j.acvd.2015.01.010 [doi]
AB  - BACKGROUND: Hypertrophic cardiomyopathy (HCM) causes various degrees of fibrosis 
      resulting in left ventricular function impairment, which can be measured using 
      mitral annular plane systolic excursion (MAPSE). AIMS: To determine the values 
      for septal, lateral and average MAPSE using cardiovascular magnetic resonance 
      (CMR) in healthy controls and patients with HCM; and to investigate whether MAPSE 
      correlated with the extent of fibrosis. METHODS: Patients with HCM and healthy 
      controls underwent CMR. RESULTS: In 50 healthy controls, septal and lateral MAPSE 
      were comparable and showed excellent intra- and inter-observer reliability. 
      Patients with HCM had significantly reduced septal, lateral and average MAPSE 
      compared to healthy controls. Furthermore, in patients with HCM, septal MAPSE 
      measurements were significantly reduced compared to lateral ones. 
      Correspondingly, the septal myocardial segments showed significantly more late 
      gadolinium enhancement (LGE) than lateral ones. No significant differences were 
      found between echocardiographic and CMR MAPSE measurements in healthy controls 
      and patients with HCM. Patients who suffered a major adverse cardiac event or 
      stroke revealed a significantly reduced MAPSE and a significantly greater LGE 
      extent compared to event-free patients with HCM. CONCLUSIONS: MAPSE measurement 
      using CMR is feasible, reproducible and comparable to echocardiography in healthy 
      controls and patients with HCM. The asymmetric and mainly septal distribution of 
      myocardial hypertrophy and fibrosis detected by LGE in patients with HCM was 
      reflected by significantly reduced septal versus lateral MAPSE. Therefore, 
      reduced MAPSE seems to be an easily determinable marker of fibrosis accumulation 
      leading to left ventricular mechanical dysfunction and also seems to have a 
      prognostic implication.
CI  - Copyright (c) 2015 Elsevier Masson SAS. All rights reserved.
FAU - Doesch, Christina
AU  - Doesch C
AD  - 1st Department of Medicine Cardiology, University Medical Center Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany. Electronic address: Christina.Doesch@umm.de.
FAU - Sperb, Amelie
AU  - Sperb A
AD  - 1st Department of Medicine Cardiology, University Medical Center Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany.
FAU - Sudarski, Sonja
AU  - Sudarski S
AD  - DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany; Institute of Clinical Radiology and Nuclear Medicine, University Medical 
      Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, 
      Germany.
FAU - Lossnitzer, Dirk
AU  - Lossnitzer D
AD  - 1st Department of Medicine Cardiology, University Medical Center Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany.
FAU - Rudic, Boris
AU  - Rudic B
AD  - 1st Department of Medicine Cardiology, University Medical Center Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany.
FAU - Tulumen, Erol
AU  - Tulumen E
AD  - 1st Department of Medicine Cardiology, University Medical Center Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany.
FAU - Heggemann, Felix
AU  - Heggemann F
AD  - 1st Department of Medicine Cardiology, University Medical Center Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany.
FAU - Schimpf, Rainer
AU  - Schimpf R
AD  - 1st Department of Medicine Cardiology, University Medical Center Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany.
FAU - Schoenberg, Stefan O
AU  - Schoenberg SO
AD  - DZHK (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany; Institute of Clinical Radiology and Nuclear Medicine, University Medical 
      Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, 
      Germany.
FAU - Borggrefe, Martin
AU  - Borggrefe M
AD  - 1st Department of Medicine Cardiology, University Medical Center Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany.
FAU - Papavassiliu, Theano
AU  - Papavassiliu T
AD  - 1st Department of Medicine Cardiology, University Medical Center Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site Mannheim, Mannheim, 
      Germany.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150408
PL  - Netherlands
TA  - Arch Cardiovasc Dis
JT  - Archives of cardiovascular diseases
JID - 101465655
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/complications/diagnostic imaging/*pathology
MH  - *Contrast Media
MH  - Female
MH  - Fibrosis
MH  - Follow-Up Studies
MH  - *Gadolinium
MH  - Heart Septum/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*pathology
MH  - Motion
MH  - Observer Variation
MH  - Organ Size
MH  - Prognosis
MH  - Ultrasonography
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*etiology/pathology
OTO - NOTNLM
OT  - Cardiomyopathie hypertrophique
OT  - Cardiovascular magnetic resonance imaging
OT  - Cicatrices myocardiques
OT  - Excursion systolique dans le plan de l'anneau mitral
OT  - Fibrosis
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - L'imagerie par resonance magnetique
OT  - Mitral annular plane systolic excursion
OT  - Rehaussement tardif
EDAT- 2015/04/13 06:00
MHDA- 2016/04/27 06:00
CRDT- 2015/04/13 06:00
PHST- 2014/09/10 00:00 [received]
PHST- 2014/11/13 00:00 [revised]
PHST- 2015/01/26 00:00 [accepted]
PHST- 2015/04/13 06:00 [entrez]
PHST- 2015/04/13 06:00 [pubmed]
PHST- 2016/04/27 06:00 [medline]
AID - S1875-2136(15)00047-9 [pii]
AID - 10.1016/j.acvd.2015.01.010 [doi]
PST - ppublish
SO  - Arch Cardiovasc Dis. 2015 Jun-Jul;108(6-7):356-66. doi: 
      10.1016/j.acvd.2015.01.010. Epub 2015 Apr 8.